Clinical trials: Pulmonary Emphysema
Chronic Obstructive Pulmonary Disease (COPD), Emphysema
Home Pulmonary Rehabilitation for COPD
Regular physical activity has been found to be important in maintaining health and well-being in people with COPD. The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more…
- Trial name
- NCT03480386
- Testing
- Home Based Pulmonary Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 375 people
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease, Emphysema
Macrophages in Smokers' Lung
Cigarette smoking causes an increase in inflammation in the lungs. In about 20% of smokers this inflammation leads to damage in lungs including making holes in the lung tissue.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT00298402
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
COPD, Emphysema
A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System.
Rationale: The combined data from 3 studies outside the Unites States investigating the Lung Volume Reduction Coil system (RePneu LVRC) showed statistically significant improvements in pulmonary function, exercise capacity and…
- Trial name
- RECOIL (NCT02012673)
- Testing
- Bronchoscopic lung volume reduction
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- University Medical Center Groningen
Emphysema, Chronic Obstructive Pulmonary Disease
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction
To establish and confirm the safety and clinical utility of BTVA applied unilaterally for lung volume reduction in patients with upper lobe predominate heterogeneous severe emphysema.
- Trial name
- BTVA (NCT01102712)
- Testing
- BTVA System
- Where
- 10 sites in Australia, Austria and 2 more
- Volunteers
- 34 people
- Sponsor
- Uptake Medical Corp
Respiratory Distress Syndrome, Pneumothorax/Pulmonary Intersticial Emphysema
Very Early Surfactant and NCPAP for Premature Infants With RDS
The present study will test the use of very early nasal continuous airway pressure(NCPAP)with and without surfactant in premature infants with clinical evidence or respiratory distress syndrome.
- Conditions
- Respiratory Distress Syndrome, Pneumothorax/Pulmonary Intersticial Emphysema, Chronic Lung Disease
- Trial name
- CNRNCPAP (NCT00563641)
- Testing
- Very early surfactant and bubble NCPAP, bubble NCPAP
- Where
- Colombia
- Volunteers
- 278 people
- Sponsor
- Colombian Neonatal Research Network
Emphysema
TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)
This 2 arm study will investigate the efficacy, safety and tolerability of RAR Gamma versus placebo in ex-smokers with moderate or severe emphysema treated with optimal COPD therapy.
- Trial name
- NCT00413205
- Testing
- RAR Gamma
- Where
- 64 sites in United States, Bulgaria and 10 more
- Volunteers
- 491 people
- Sponsor
- Hoffmann-La Roche
Pulmonary Emphysema
Study of the AeriSeal System for HyPerInflation Reduction in Emphysema (ASPIRE)
The purpose of this study is to demonstrate the safety and efficacy of AeriSeal System treatment plus optimal medical therapy compared in patients with advanced upper lobe predominant (ULP) heterogeneous emphysema.
- Trial name
- ASPIRE (NCT01449292)
- Testing
- Treatment plus Optimal Medical Therapy, Optimal Medical Therapy
- Where
- 40 sites in United States, France and 5 more
- Volunteers
- 300 people
- Sponsor
- Aeris Therapeutics
Alpha-1 Antitrypsin Deficiency (AATD)
A Phase 1 Research Study to Evaluate Safety, Tolerability, and Pharmacokinetics of WVE-006 in Healthy Participants With Wild-type AAT Expression (RestorAATion-1)
This study is the first study in the RestorAATion clinical program. The purpose of this first-in human (FIH), double-blind, randomized, placebo-controlled, single ascending dose (SAD) and multiple-dose Phase 1 study is to assess…
- Trial name
- RestorAATion-1 (NCT06186492)
- Testing
- WVE-006
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wave Life Sciences USA, Inc.
Coronary Disease, Emphysema or COPD
Maximizing Benefit of Lung Cancer Screening Incidental Findings of Cardiovascular, Respiratory and Breast Measures
The investigators will implement a patient-centered outcomes tool for participants in lung cancer screening programs that receive clinically important incidental findings relevant to heart, breast and lung health.
- Conditions
- Coronary Disease, Emphysema or COPD, Breast Density
- Trial name
- NCT05900544
- Testing
- System implementation of patient-centered incidental findings report
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Montana
Chronic Pulmonary Obstructive Disease, Emphysema
A Registry Study of the AeriSeal® System or Lung Volume Reduction in Patients With Advanced Emphysema
The purpose of this study is to provide post market clinical follow-up (PMCF) to obtain long term safety and efficacy information about the AeriSeal System treatment in patients with advanced emphysema.
- Trial name
- NCT01449175
- Where
- 8 sites in Austria, France and 2 more
- Volunteers
- 54 people
- Sponsor
- Aeris Therapeutics
Chronic Obstructive Pulmonary Disease, Emphysema
Endobronchial Valve in Patients With Heterogeneous Emphysema
To compare the clinical outcomes of Endoscopic Lung Volume Reduction using Pulmonx Zephyr Endobronchial Valve (EBV) vs. Standard of Care (SoC) in the treatment of heterogeneous emphysema patients in a controlled trial design…
- Trial name
- NCT02823223
- Testing
- Zephyr endobronchial valve placement
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Chinese PLA General Hospital
Pulmonary Disease, Pulmonary Emphysema
In Vivo Endomicroscopic Description of Pulmonary Microcirculation in Systemic Sclerosis and Emphysema Patients
Systemic sclerosis (SSc) is a generalized disorder of connective tissue, arterioles and microvessels, characterized by the occurrence of fibrosis and vascular obliteration phenomena.
- Trial name
- MiPECSE (NCT02556697)
- Testing
- Bronchoscopy with in vivo confocal endomicroscopy
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Rouen
Chronic Obstructive Pulmonary Disease, Emphysema
Lung Volume Reduction Coil Microbiome Study
Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema
- Trial name
- LVRC-Micro (NCT03010566)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Adipose Derived Cells for Chronic Obstructive Pulmonary Disease
The intent of this clinical study is to answer the questions: 1) Is the proposed treatment safe and 2) Is treatment effective in improving the disease pathology of patients with diagnosed with chronic obstructive pulmonary…
- Trial name
- NCT02041000
- Testing
- Adipose Derived Stem Cells
- Where
- United States
- Sponsor
- Bioheart, Inc.
Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic
Eccentric Exercise Training as Novel Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD)
The main purpose of this project is to establish the additional value of eccentric versus concentric exercise to optimize muscle function in patients with severe COPD.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic, Emphysema
- Trial name
- NCT01077102
- Testing
- Eccentric exercise training
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pulmonary Emphysema, COPD
AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation
The purpose of this study is to characterize the safety and efficacy of the AeriSeal System in patients with advanced upper lobe predominant emphysema and significant collateral ventilation as determined by the Chartis System.
- Conditions
- Pulmonary Emphysema, COPD, Lung Diseases
- Trial name
- CV+ (NCT01460108)
- Testing
- AeriSeal System
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Emphysema
Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy
Since medical therapies offer only modest palliation and minimal hopes for improved survival to COPD patients, surgical therapies have been designed that may provide greater benefits in selected patients.
- Trial name
- NCT03673176
- Testing
- Stereotactic Ablative Radiotherapy (SABR)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Alpha1 Antitrypsin Deficiency, Alpha1-Proteinase Inhibitor Deficiency
Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of Respreeza / Zemaira Weekly for 3 Years in Adults With alpha1 Antitrypsin Deficiency (AATD)
This is a multicenter, parallel-group, double-blind, randomized phase 4 study designed to identify the optimal dose of CE1226 (2 active doses) to slow disease progression as assessed by reduced rates of annual lung density…
- Conditions
- Alpha1 Antitrypsin Deficiency, Alpha1-Proteinase Inhibitor Deficiency, Emphysema
- Trial name
- NCT07326592
- Testing
- CE1226
- Where
- 2 sites in Denmark
- Volunteers
- 270 people
- Sponsor
- CSL Behring
Chronic Obstructive Pulmonary Disease, Emphysema
Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Emphysema
Chronic Obstructive Pulmonary Disease has two heterogeneous conditions (chronic bronchitis and pulmonary emphysema phenotypes) with a different clinical presentation.
- Trial name
- NCT01305668
- Where
- 5 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Villa Pineta Hospital
Chronic Obstructive Pulmonary Disease, Emphysema
Inhaled Steroid Reduces Systemic Inflammation in COPD
Systemic inflammation is present in chronic obstructive pulmonary disease (COPD), which has been linked to cardiovascular morbidity and mortality.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT00175565
- Testing
- inhaled fluticasone 500 mcg b.i.d.
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia