Clinical trials: Pulmonary Diseases or Conditions
Multiple Sclerosis, Demyelinating Autoimmune Diseases, CNS
Humoral and T-Cell Responses to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab Treated With Ocrelizumab or Natalizumab
The primary goal of this study is to provide additional data regarding B and T-cell mediated responses to COVID-19 vaccines in MS patients treated with OCR and to determine which clinical and paraclinical variables correlating…
- Conditions
- Multiple Sclerosis, Demyelinating Autoimmune Diseases, CNS, Autoimmune Diseases of the Nervous System, Nervous System Diseases
- Trial name
- OCR-VAX (NCT04837651)
- Testing
- Elecsys semi-quantitative Anti-SARS-CoV-2 antibody test, T-Detect COVID T-cell blood test
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dragonfly Research, LLC
Coronary Disease, Emphysema or COPD
Maximizing Benefit of Lung Cancer Screening Incidental Findings of Cardiovascular, Respiratory and Breast Measures
The investigators will implement a patient-centered outcomes tool for participants in lung cancer screening programs that receive clinically important incidental findings relevant to heart, breast and lung health.
- Conditions
- Coronary Disease, Emphysema or COPD, Breast Density
- Trial name
- NCT05900544
- Testing
- System implementation of patient-centered incidental findings report
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Montana
Smoke-related Lung Diseases, Chronic Obstructive Pulmonary Disease
Impact of Fluticasone and Salmeterol on Airway Dendritic Cells (DCs) in Smokers
Airway dendritic cells (DCs) play a key role in smoke-related lung diseases. In this study, the researchers investigate the effects of fluticasone and salmeterol on human airway DCs in smokers.
- Trial name
- NCT00908362
- Testing
- fluticasone, fluticasone/salmeterol
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Rhinosinusitis
Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents
Chronic rhinosinusitis (CRS) is common disorder which affects up to 13% of the US population. CRS affects numerous Quality of Life (QOL) factors including smell, sleep and communication.
- Trial name
- NCT00948519
- Testing
- Laser + ICG, Laser only
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York Head & Neck Institute
Asthma
Effects of Papworth Breathing With or Without Bridge Pose Yoga in Asthma Patients
Asthma is a chronic condition causing airway inflammationandconstriction, leading to symptoms like shortness of breath, wheezing, andchest tightness.
- Trial name
- NCT07440953
- Testing
- Papeworth Breathing, Pap-worth Breathing + Bridge Pose Yoga
- Where
- Pakistan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Asthma, Chronic Obstructive Pulmonary Disease
Pharmacokinetic Comparability of Benralizumab Using Accessorized Pre-Filled Syringe or Autoinjector in Healthy Volunteers
An open-label, single dose Pharmacokinetic (PK) comparability study to demonstrate comparable drug exposure following Subcutaneous benralizumab administration by using accessorized pre-filled syringe (APFS) or autoinjector (AI)…
- Trial name
- NCT02968914
- Testing
- Benralizumab
- Where
- 2 sites in Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
SARS-CoV Infection
Comparison of Strategies Based on RT-PCR or Antigenic Test for the Screening of SARS-CoV-2 Infection (COVID-19).
The virological diagnosis of SARS-CoV-2 infection is pivotal for the control of the outbreak by large screening of a- or pauci-symptomatic subjects.
- Trial name
- AutoCoV (NCT04859023)
- Testing
- saliva sample combined to an anterior nare self-swabbing (Self-samples), saliva sample (Self-sample), Survey of SARS-COV-19 knowledge
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy, Pulmonary Disease, Chronic Obstructive
Relative Bioavailability of of Olodaterol and Ketoconazole
This clinical trial is intended to investigate a possible effect of the p-gp inhibitor ketoconazole on the bioavailability of olodaterol
- Trial name
- NCT01153711
- Testing
- BI 1744, Ketoconazole
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Alcohol Use, Unspecified, Substance Use
Ambulance Calls for Substance Use and Alcohol in a Pandemic (ASAP)
The Primary objective is to explore ambulance service attendance at incidents involving alcohol and/or substance use over the period of the pandemic lockdown, and the following months.
- Conditions
- Alcohol Use, Unspecified, Substance Use, Intoxication Alcohol, Emergencies
- Trial name
- ASAP (NCT04474444)
- Testing
- attendance by ambulance crew
- Where
- United Kingdom
- Volunteers
- 55,000 people, healthy volunteers welcome
- Sponsor
- University of Lincoln
Heart Failure, COPD
Effect of the Use of Protective Masks on the Ability to Perform Daily Activities in Patients with Heart Failure or Obstructive Pulmonary Disease
Scientific Rationale: In late 2019 and early 2020, researchers at the Wuhan Institute of Virology identified a potential new etiologic agent, called new coronavirus 2019 (nCoV-2019).
- Trial name
- NCT05762406
- Testing
- Respiratory protective mask
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Cognitive Decline, Cognitive Dysfunction
Open-label, Post-marketing, Prospective Study to Assess Impact of COVID-19 on Cognitive Function in Patients
The objective of this study is to compare the impact of the coronavirus disease (SARS-CoV-2, or COVID-19) on cognitive function in the population of patients who have been diagnosed, treated and recovered from the COVID-19…
- Conditions
- Cognitive Decline, Cognitive Dysfunction, Brain Health, Post CoV-2 Syndrome
- Trial name
- COVID19 (NCT04950673)
- Testing
- Cognivue
- Where
- 4 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cognivue, Inc.
Diagnostic Imaging
PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Safety and Tolerability in Healthy Volunteers and Safety, Tolerability and Diagnostic Performance of BAY86-9596 in Patients With Non-small Cell Lung Cancer, Breast Cancer, Head and Neck Cancer and Patients With Inflammations
Visual assessment of diagnostic PET/CT (positron emission tomography/computed tomography) images obtained after a single intravenous injection of BAY86-9596 in patients with cancer and inflammation
- Trial name
- NCT01089998
- Testing
- BAY86-9596, Fludeoxyglucose (18F)-IBA
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Lantheus Biosciences Ltd.
Cardiovascular Disease, Healthcare Associated Infectious Disease
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
The investigators will conduct qualitative interviews of hospital personnel regarding HAI prevention practices, and use coded data from these interviews to assist in developing standardized practices.
- Conditions
- Cardiovascular Disease, Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Deep Sternal Infection
- Trial name
- NCT02073760
- Testing
- There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Inadequate or Impaired Respiratory Function, Diabetes
Effects of Respiratory Muscle Training in Obese Women
The objective of this study will be to evaluate the effects of inspiratory muscle training (IMT) on the physical fitness of obese women It is believed that the application of these exercises helps in the improvement of…
- Conditions
- Inadequate or Impaired Respiratory Function, Diabetes, Hypertension
- Trial name
- NCT03767556
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
COPD, Heart Failure, Congestive
Clinical Assessment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and/or Chronic Heart Failure (CHF)
Cigarette smoking, the major risk factor for COPD, causes not only airway and lung inflammation, but also systemic effects. These systemic effects of smoking could substantially contribute to the development of chronic diseases…
- Trial name
- NCT01114386
- Testing
- Lung function testing, echocardiography, blood sampling
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Interstitial Lung Disease, Chronic Kidney Diseases
Safety, Tolerability, PK and PD Study of AD-214 Administered to Healthy Volunteers and Patients With Interstitial Lung Disease or Chronic Kidney Disease
This is a Phase I, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of a 10 mg/kg dose of AD-214 when administered to healthy volunteers…
- Trial name
- NCT05914909
- Testing
- AD-214
- Where
- Australia
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AdAlta Limited
Laryngoscope, Hemoptysis
Comparison of Intubation With Direct Laryngoscopy or Videolaryngoscopy in an Hemoptysis Simulated Situation on Human Cadaver Embalmed With Thiel's Method
Our study first aims to develope a realistic cadaver model of hemoptysis based on Thiel's embalmed cadavers. Secondly, participants will intubate the hemoptysis cadaver model with (a) the direct laryngoscopy with MacIntosh blade…
- Conditions
- Laryngoscope, Hemoptysis, Simulation, Cadaver
- Trial name
- NCT04087135
- Testing
- direct laryngoscopy, videolaryngoscopy McGrath, videolaryngoscopy McGrath with suction
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Respiratory Distress, Transient Tachypnea of the Newborn
Effect of Supine or Prone Position After Caesarean Birth
Respiratory Distress is a frequent clinical diagnosis of babies delivered by elective Caesarean birth. There has been no study comparing the efficacy of immediately positioning a newly born infant prone vs.
- Conditions
- Respiratory Distress, Transient Tachypnea of the Newborn, Delayed Transition of the Newborn, Persistent Pulmonary Hypertension
- Trial name
- NCT01310153
- Testing
- prone positioning, Supine
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Safety and Tolerability
PK and PD Profile of Dance 501 in Healthy, Non-diabetic Subjects With Mild to Moderate Asthma or COPD
This will be a randomized, open-label, active-controlled, single dose crossover study with either three or four treatment periods.
- Trial name
- NCT03307512
- Testing
- inhaled human insulin, Insulin Lispro (Humalog U-100)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dance Biopharm Inc.