Clinical trials: Ptosis, active
Brow Ptosis, Dermatochalasis
Enhancing the Durability of Thread-Assisted Brow Suspension Through Upper Blepharoplasty-Assisted Ligament Release
This prospective clinical study aims to investigate whether combining upper blepharoplasty with limited release of the lateral brow-retaining ligaments improves the long-term effectiveness of barbed thread brow suspension.
- Conditions
- Brow Ptosis, Dermatochalasis, Periorbital Aging
- Trial name
- NCT07879456
- Testing
- Upper Blepharoplasty, Barbed Thread Brow Suspension, Lateral Brow-Retaining Ligament Release
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Muhammed Mustafa Demirok
Mitral Valve Insufficiency
Prognostic Impact of Imaging Parameters in Patients With Primary Mitral Insufficiency by Prolapse (COHORTE-IM)
Degenerative mitral insufficiency secondary to valve prolapse is the most common valve disease in Western countries. In the absence of specific treatment, it spontaneously progresses to heart failure and death when it is severe.
- Trial name
- COHORTE-IM (NCT03962023)
- Testing
- Echocardiography and MRI
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Lille Catholic University
Pelvic Organ Prolapse, Cystocele
Study Comparing Transobturator Cystocele vs. Anterior Vaginal RepairS
Surgical correction of the prolapse in the anterior compartment remains one of the major challenges in urogynecology. Paravaginal defect in level II of vaginal fixation results in the majority of cystoceles.
- Conditions
- Pelvic Organ Prolapse, Cystocele, Cystocele and Incomplete Uterovaginal Prolapse
- Trial name
- STARS (NCT05602246)
- Testing
- Transobturator cystocele repair, Anterior colporrhaphy
- Where
- 8 sites in Czechia, Slovakia
- Volunteers
- 592 people
- Sponsor
- Charles University, Czech Republic
Pelvic Organ Prolapse (POP), Cystocele
Poly-L-Lactic Acid for Vulvovaginal Tissue Regeneration
Pelvic organ prolapse (POP) is a condition characterized by descent of vaginal walls, uterus and cervix, or the perineum and causes a sensation of vaginal bulge and pelvic pressure.
- Conditions
- Pelvic Organ Prolapse (POP), Cystocele, Pelvic Floor Disorder
- Trial name
- NCT07544667
- Testing
- Poly-L-Lactic Acid (Sculptra) injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cassandra Kisby
Pelvic Organ Prolapse
Enabling Self-Care for Pessary Users in Rural Setting
This study is to see if a using new collapsible pessary (Reia pessary) for treatment of pelvic organ prolapse will allow patients to care for their prolapse on their own, rather than having to come to be seen by a provider in the…
- Trial name
- ESCAPE (NCT07084818)
- Testing
- Reia System pessary self-care management, Standard pessary office-based management
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pelvic Organ Prolapse, Prolapse
POMEGRANATE Trial: Comparing Reia Pessary Versus Standard of Care Pessary for Pelvic Organ Prolapse Treatment
This multi-centered, randomized controlled trial will evaluate the safety and efficacy of home use of the novel Reia System (RS), which includes the Reia pessary and applicator, compared to standard pessary care (Gellhorn or ring…
- Trial name
- POMEGRANATE (NCT06634459)
- Testing
- Reia System, Standard of Care Pessary
- Where
- 9 sites in United States
- Volunteers
- 218 people
- Sponsor
- Medstar Health Research Institute
Lower Urinary Tract Symptoms, Stress Urinary Incontinence
Pelvic Floor Disorder Symptoms in Women Seeking Weight Loss Therapy
The purpose of this study is to compare change in pelvic floor symptoms between patients receiving medical therapy for weight loss and surgical treatment for weight loss.
- Conditions
- Lower Urinary Tract Symptoms, Stress Urinary Incontinence, Urge Urinary Incontinence, Overactive Bladder
- Trial name
- NCT07175805
- Testing
- Bariatric Surgery, GLP1 receptor agonist
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hartford HealthCare
Mitral Valve Prolapse
STretch and Myocardial Characterization in Arrythmogenic Mitral Valve Prolapse-2
Mitral valve prolapse (MVP) is a frequent affection of the mitral valve with a prevalence of 2-3% in the general population. This valvular disease is generally considered as benign, but may at term evolve toward mitral valve…
- Trial name
- STAMP-2 (NCT04852731)
- Testing
- Cardiac MRI, Blood collection, Prolongation of the MRI examination
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Central Hospital, Nancy, France
Pelvic Organ Prolapse
Patient Education in the Clinical Management of Pessary
This study is a prospective, randomized, controlled, single-blinded, multi-center clinical trial. Symptomatic patients with pelvic organ prolapse (POP) stage II, III or IV arranged to undergo pessary treatment will be randomized…
- Trial name
- NCT06432218
- Testing
- video education, conventional education
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Peking Union Medical College Hospital
Prolapse; Female, Prolapse Genital
Transvaginal Human Acellular Dermal Matrix for Prolapse Treatment
This is a randomised study in which we compare the effectiveness of three different procedures in mending symptomatic anterior and apical prolapse in patients who are candidates to receive surgery.
- Conditions
- Prolapse; Female, Prolapse Genital, Prolapse Uterovaginal
- Trial name
- NCT06404931
- Testing
- Vaginal hysterectomy plus matrix reinforcement and sacrospinous fixation with Anchorsure® device, Vaginal hysterectomy plus anterior colporrhaphy, Vaginal hysterectomy plus sacrospinous fixation with Anchorsure® device
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Mutua de Terrassa
Incontinence, Prolapse
A Telehealth Intervention to Increase Patient Preparedness for Surgery in Latinas
There are 3 aims of this study. In Aim 1 community patient partners will be enrolled to help guide the research being performed in all of the aims.
- Trial name
- TIPPS-Urogyn (NCT06679621)
- Testing
- Telehealth intervention
- Where
- United States
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pelvic Floor Dysfunction, Urinary Incontinence
Impact of Equestrian Sports, CrossFit, and Gym Training on Pelvic Floor Health (PELFISPORT )
This observational cross-sectional study investigates the impact of equestrian sports, CrossFit, and gym training on pelvic floor health in both athletes and non-athletes.
- Conditions
- Pelvic Floor Dysfunction, Urinary Incontinence, Pelvic Organ Prolapse (POP), Chronic Pelvic Pain
- Trial name
- PELFISPORT (NCT06848634)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Heart Valve Diseases, Aortic Valve Stenosis
Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice
Valvular heart disease (VHD) is a growing public health concern globally, with increasing disease burden and rising interest in advanced treatment strategies such as transcatheter interventions.
- Conditions
- Heart Valve Diseases, Aortic Valve Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- NCT07068633
- Where
- 2 sites in South Korea
- Volunteers
- 30,000 people
- Sponsor
- Yonsei University
Abnormal Uterine Bleeding, Endometriosis
Performance of SYMMCORA® vs. V-Loc® Suture Material in Patients Undergoing Laparoscopic Total Hysterectomy
The aim of this study is to show the superiority of the new unidirectional barbed suture (SYMMCORA® mid-term, unidirectional) to conventional suture material in terms of time to perform the vaginal cuff closure during gynecologic…
- Conditions
- Abnormal Uterine Bleeding, Endometriosis, Uterine Prolapse, Uterine Cancer
- Trial name
- BARHYSTER (NCT06024109)
- Testing
- Closure of the Vaginal Cuff after Total Hysterectomy
- Where
- 2 sites in Germany, Spain
- Volunteers
- 132 people
- Sponsor
- Aesculap AG
Pelvic Organ Prolapse, Female Urogenital Diseases
Pelvic Organs Prolapse Treatment Using Neodymium Laser
The aim of this prospective study is investigation of efficiency and safety of medical device "Magic Max" ("Magic Gyno" from August 2024) for preoperative treatment of pelvic organs prolapse I-II degree of severity.
- Trial name
- NCT05000957
- Testing
- Laser Treatment, Blood analysis, Сlinical urine test
- Where
- Russia
- Volunteers
- 129 people
- Sponsor
- MeLSyTech, Ltd
Mitral Valve Prolapse, Left Ventricular Fibrosis
PRIMARY Ancillary Substudy
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological…
- Conditions
- Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
- Trial name
- NCT07103733
- Testing
- Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy
- Where
- 25 sites in United States, Germany and 1 more
- Volunteers
- 250 people
- Sponsor
- Annetine Gelijns
Genital Prolapse
Laparoscopic Pectopexy With and Without Mesh Use for Pelvic Organ Prolapse.
Genital apical prolapse refers to the descent of the vaginal apex, uterus, or cervix, and surgical treatment is required for adequate apical support.
- Trial name
- NCT07306715
- Testing
- Meshless Laparoscopic Pectopexy, Laparoscopic Pectopexy with mesh
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kocaeli University
Pelvic Organ Prolapse (POP)
Vaginal Estrogen for Improvement of Outcomes Following Pelvic Organ Prolapse Surgery
This open-label randomized control trial will study the use of vaginal estrogen in the first six weeks after pelvic organ prolapse (POP) repair surgery.
- Trial name
- VEPO (NCT07030426)
- Testing
- Vaginal Estrogen - Twice Weekly, Vaginal Estrogen - Daily
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- Sarah Wozney
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Postmenopausal Period, Vaginal Atrophy
Treatment of Vaginal Atrophy With Low Intensity Nanosecond Neodymium Laser
The aim of study is characteristic of changes in the vaginal wall after treatment of neodymium laser radiation with a wavelength of 1064 nm.
- Conditions
- Postmenopausal Period, Vaginal Atrophy, Vaginal Prolapse
- Trial name
- NCT05335317
- Testing
- Laser Treatment, Topical hormone estriol, Сlinical blood analysis
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MeLSyTech, Ltd