Clinical trials: Pruritus, open to volunteers
Lichen Sclerosus of Vulva
Nemolizumab for LS
Patients ≥ 18 years of age with Lichen sclerosis (LS)
- Trial name
- NCT07704775
- Testing
- Nemolizumab 30 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
Lichen Simplex Chronicus
A Study to Evaluate the Multiple Dose Ascending of PG-033 in Healthy Adult Participants.
The goal of this study is to evaluate the safety, tolerability and pharmacokinetics (PK) profiles of multiple ascending oral doses(MAD) of PG-033 by directly comparing it with placebo.
- Trial name
- NCT07619183
- Testing
- PG-033 tablets
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Prime Gene Therapeutics Co., Ltd.
Itch
Role of Interleukin-13 Pathways on Pain and Itch Sensitivity
Atopic dermatitis (AD) is as chronic, inflammatory skin disorder affecting 20% of the world's population. Intense itch and skin pain are the main symptoms.
- Trial name
- IL-13 (NCT06503510)
- Testing
- Histamine, Cowhage, bovine adrenal medulla (BAM8-22)
- Where
- 3 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Immunotherapy-related Pruritus
TriCalm Hydrogel® in the Treatment of Immunotherapy-Related Pruritus
This is a phase 2, randomized, open-label, single-center study that will assess the efficacy of TriCalm Hydrogel®, a topical gel containing strontium, for treating pruritus related to immune checkpoint inhibitors (ICIs).
- Trial name
- NCT06748404
- Testing
- TriCalm Hydrogel®, Triamcinolone acetonide 0.1% cream
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Diego
Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC)
The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe Itching
Cholestatic liver diseases are characterized by jaundice, pruritus, and elevated levels of alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT).
- Conditions
- Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC), Atopic Dermatitis (AD)
- Trial name
- NCT07678645
- Testing
- Upadacitinib 15 MG
- Where
- China
- Volunteers
- 44 people
- Sponsor
- RenJi Hospital
Senile Pruritus
The Effect of Intraoperative Esketamine Infusion on Pruritus in Elderly Surgical Patients
To explore the effect of intraoperative esketamine on pruritus in elderly patients undergoing elective general anesthesia for knee replacement surgery
- Trial name
- NCT07597486
- Testing
- Esketamine, Normal Saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University General Hospital
Pruritus
Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study
Chronic pruritus affects 10-20% of the population and causes a major reduction in quality of life, comparable to pain, with significant psychological, social, and functional consequences.
- Trial name
- CANNA-ITCH (NCT06435299)
- Testing
- Cannabis oil
- Where
- 6 sites in France
- Volunteers
- 218 people
- Sponsor
- University Hospital, Brest
Pruritus, Chronic Pruritus
Establishment of a Patient Library in Patients With Pruritus Sine Materia
Very little is currently known about the pathophysiology of pruritus sine materia according to the etiology. The creation of this cohort should make it possible to improve our clinical and biological knowledge according to the…
- Conditions
- Pruritus, Chronic Pruritus, Itch
- Trial name
- PRURITHEQUE (NCT05678309)
- Testing
- Blood samples, skin swab sample, skin biopsy sample
- Where
- France
- Volunteers
- 175 people
- Sponsor
- University Hospital, Brest
Dry Skin
Evaluation of the Effect of Combined Use of Cosmetic Products for Dry and Itchy Skin.
The goal of this study is to learn if combined use of shower oleogel and body lotion works to improve skin itching and dryness in adults. It will also learn about its safety.
- Trial name
- NCT07695805
- Testing
- Shower oleogel and body lotion, Shower gel and body lotion
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lacer S.A.
Patients With Chronic Pruritus for More Than 1 Month Who Have Received Immunotherapy
Evaluation of the Prevalence of BP180 and BP230 Autoantibodies in the Serum of Patients With Pruritus Under Immunotherapy
The aim of the study is to evaluate the prevalence of positive anti BP180 and/or anti BP230 serology in the serum of patients with chronic and diffuse pruritus for at least 1 month under immunotherapy and in the absence of…
- Trial name
- BPA_immun (NCT05689463)
- Testing
- characterisation of immunoglobulin subclasses
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
End-Stage Renal Disease Requiring Haemodialysis, Mobile Application
Evaluation of the Effectiveness of a Mobile Application Developed for Hemodialysis Patients.
This study aims to evaluate the effectiveness of a mobile health application developed for adult patients undergoing hemodialysis treatment.
- Trial name
- NCT07211100
- Testing
- Mobile Health Application
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Saglik Bilimleri Universitesi
Burn, Chronic Pain Following Thermal Burn Injury
VR-PMR for Post-Burn Symptoms
The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep…
- Conditions
- Burn, Chronic Pain Following Thermal Burn Injury, Non-Pharmacological Interventions, Virtual Reality
- Trial name
- VIBE (NCT07317271)
- Testing
- Virtual Reality-Enhanced Progressive Muscle Relaxation, Standard Progressive Muscle Relaxation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Johns Hopkins University
Notalgia Paresthetica
High-power Laser Therapy for Notalgia Paresthetica.
A non-invasive modality for the management of neuromusculoskeletal pain conditions that has emerged as a compelling option is high-power laser therapy (HPLT).
- Trial name
- NCT07356362
- Testing
- High-power laser
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Uşak University
Pregnancy Related, Atopic Dermatitis
An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis Exposed to Ruxolitinib Cream Versus Topical Corticosteroids During Pregnancy: A US Claims Database Analysis
This study is to assess infant outcomes of women with AD who were exposed to ruxolitinib cream during pregnancy compared with a control cohort of women with AD who were exposed to a topical corticosteroid (TCS) during pregnancy.
- Trial name
- NCT06627335
- Testing
- Ruxolitinib Cream, TCS
- Where
- United States
- Volunteers
- 5,621 people
- Sponsor
- Incyte Corporation
Pruritus
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
The main objective of the study is to assess efficacy and safety of dupilumab given up to 24 weeks in adults with CPUO. This is a master protocol which includes 2 parallel-treatment, double-blind, 2- arm Phase 3 staggered studies…
- Trial name
- NCT05263206
- Testing
- Dupilumab, Fexofenadine (loratadine if not available)
- Where
- 94 sites in United States, Argentina and 11 more
- Volunteers
- 284 people
- Sponsor
- Sanofi
CKD (Chronic Kidney Disease) Stage 5D, Hemodialysis
Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis
This randomized controlled trial aims to evaluate the effect of polymethylmethacrylate dialysis membranes use on the intensity of pruritus in patients with CKD stage 5D receiving maintenance hemodialysis.
- Conditions
- CKD (Chronic Kidney Disease) Stage 5D, Hemodialysis, Pruritis
- Trial name
- NCT06671535
- Testing
- Polymethylmethacrylate membrane, polysulfone membranes
- Where
- Russia
- Volunteers
- 62 people
- Sponsor
- Saint Petersburg State University, Russia
Atopic Dermatitis, Sleep Disturbance
Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis
Single center, prospective, Open label study of sleep, pruritus and circadian function pre/post 12-weeks of dupilumab treatment in children 6-17 years old
- Trial name
- NCT05042258
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Chronic Pruritus of Unknown Origin
A Study to Evaluate Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)
The purpose of this phase 3 study is to establish the efficacy, safety and tolerability of remibrutinib in adult participants with severe chronic pruritus of unknown origin (CPUO).
- Trial name
- NCT07700056
- Testing
- Remibrutinib
- Where
- 17 sites in United States, Argentina and 3 more
- Volunteers
- 180 people
- Sponsor
- Novartis Pharmaceuticals
Pruritis
Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic
The goal of this study is to test the efficacy of Dupixent in improving post-burn itching symptoms versus the current standard of care.
- Trial name
- NCT06226610
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Akron Children's Hospital
Histamine, Cowhage
Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch: To investigate similarity and differences between itch and pain by comparing the effect of sleep…
- Conditions
- Histamine, Cowhage, Sleep Deprivation
- Trial name
- NCT06081998
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University