Clinical trials: Pruritus
Atopic Dermatitis, Atopic Dermatitis Eczema
Bioavailability and Tolerability of Fexofenadine Hydrochloride Topical Lotion 1%
The investigational lotion is envisaged as an short- and long term "Ease \& Prevent" monotherapy for adults and children with mild to moderate eczema.
- Conditions
- Atopic Dermatitis, Atopic Dermatitis Eczema, Atopic Rash, Rash
- Trial name
- ATOFEX-1 (NCT05461456)
- Testing
- Fexofenadine Hydrochloride Topical Lotion 1% (OP2101)
- Where
- Bangladesh
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- OrchestratePharma GmbH
Food Sensitivities, Headache
NAET Screening for Food Allergy, Sensitivity and Intolerances Using IgE-Specific Antigen Test and NST- NAET®
Food allergy reactions cause various health disorders in sensitive people. These reactions may be IgE-mediated,cell-mediated, energy disturbance-mediated, or a combination of the three.
- Conditions
- Food Sensitivities, Headache, Backache, Indigestion
- Trial name
- NCT00275795
- Testing
- NAET Procedures
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nambudripad's Allergy Research Foundation
Dandruff, Seborrhoeic Dermatitis of the Scalp
Changes in Scalp Condition After Using a Moisturizer: a Prospective Clinical Trial Using Artificial Intelligence
The goal of this clinical trial is to evaluate whether a scalp moisturizer containing celastrol and Cichorium intybus root extract can improve scalp condition in adults aged 19 years or older who require scalp moisturization due…
- Trial name
- scalp (NCT07459023)
- Testing
- Ducray Kertyol P.S.O. Concentrate Cream, Ducray Laboratory, France
- Where
- South Korea
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Pain, Pruritus
Desensitization of Nociceptive Afferents by Application of Topical Capsaicin, Trans-cinnamaldehyde and L-menthol
The purpose of this study is to investigate the potential desensitising effects of repeated applications of capsaicin, trans-cinnamaldehyde and L-menthol on thermal, mechanical and chemical sensory stimulations.
- Conditions
- Pain, Pruritus, Neuropathic Pain, Dermatology/Skin - Other
- Trial name
- NCT03132142
- Testing
- Capsaicin, Trans-cinnamaldehyde, L-Menthol
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Tinea Pedis
Topical Tolnaftate Stick for Tinea Pedis: An Open-Label Interventional Study
This study is designed to evaluate the safety and effectiveness of multiple 1% tolnaftate formulations delivered through novel stick-based vehicles in individuals with tinea pedis (athlete's foot).
- Trial name
- NCT07245667
- Testing
- 1% Tolnaftate Stick Formula A, 1% Tolnaftate Stick Formula B, 1% Tolnaftate Stick Formula C
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Propedix, Inc.
Pruritus
Naloxone for the Treatment of Opioid-Induced Pruritus
The purpose of this study is to improve how we treat itching, a common side effect associated with the use of morphine pain medication.
- Trial name
- NCT01071057
- Testing
- Naloxone, Saline/Morphine
- Where
- Canada
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Atrophic Vaginitis
A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis
The purpose of this study is to determine the therapeutic equivalence of Mylan's estradiol vaginal cream to Estrace® cream and superiority of both products to placebo.
- Trial name
- NCT02195986
- Testing
- Estradiol Vaginal Cream, 0.01%, Estrace® 0.01% cream
- Where
- 21 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Itch
Investigation of a New Human Model for Itch
This third sub-project aims to evaluate the interaction between the TRPM8 receptor and pruritus by studying the anti-pruritic effect of TPRM8-agonist L-menthol on histaminergic and non-histaminergic itch induced using three…
- Trial name
- NCT04711044
- Testing
- Papain, Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Lichen Simplex Chronicus
A Phase I Clinical Trial to Evaluate the Single Dose Ascending and Food Effects of PG-033 in Healthy Adults
The goal of this study is to evaluate the safety, tolerability and pharmacokinetics (PK) profiles of single ascending oral doses(SAD) of PG-033 by directly comparing it with placebo.
- Trial name
- NCT07013097
- Testing
- PG-033
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Prime Gene Therapeutics Co., Ltd.
Atopic Dermatitis
Treatment of Nighttime Pruritus in Atopic Dermatitis
This study will look at melatonin vs. first generation antihistamine vs. placebo in improving nighttime itching in children with atopic dermatitis.
- Trial name
- NCT03688464
- Testing
- Melatonin, Diphenhydramine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Pruritus
Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section
Neuraxial anesthesia, which includes epidural anesthesia and intrathecal anesthesia, is a frequent anesthetic approach for caesarean delivery and other lower abdominal and lower limb anesthetic procedures.
- Trial name
- NCT03483870
- Testing
- Morphine Sulfate, Granisetron
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hemodialysis Complication
REIKI APPLICATION PAIN, FATIGUE AND ITCHING IN HEMODIALYSIS PATIENTS
The research sample consisted of 74 individuals, including the intervention group (n=37) and the control group (n=37), who received hemodialysis treatment at Sivas Cumhuriyet University Application and Research Hospital…
- Trial name
- NCT05531175
- Testing
- Reiki apply
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Itch
Identification of the Mechanism of Non-histaminergic Itch Inducing Epigenetic Changes
Itch is defined as an unpleasant sensation that evokes the desire to scratch. Chronic itch, defined as itch persisting for more that 6 weeks, is a key symptom in many diseases severely affects the quality of life of the affected…
- Trial name
- NCT06997926
- Testing
- blood sampling
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Hemodialysis, Uremic Pruritus
Acupressure on Uremic Pruritus and Sleep Quality Among Patients Receiving Hemodialysis
The research is to explore the effect of acupressure on uremic pruritus and sleep quality among patients receiving hemodialysis. The research method adopts the experimental research method using randomization.
- Trial name
- NCT05575193
- Testing
- Acupressure
- Where
- Taiwan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Hepatic Impairment
Study of Nalbuphine ER in Participants With Hepatic Impairment
This research study will evaluate the effect of hepatic impairment on the pharmacokinetics (the breakdown of the drug in the body) of parallel-group, multiple oral doses nalbuphine extended release (NAL ER), tablets in people…
- Trial name
- NCT04020016
- Testing
- Nalbuphine ER
- Where
- 3 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Trevi Therapeutics
ITCH
Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as…
- Trial name
- NCT07247695
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Itchiness
The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch
It is well known that itch and pain have many communalities in terms of pathways and molecules involved. Therefore, it is very important to investi-gate different substances that work against both pain and itching.
- Trial name
- NCT07203274
- Testing
- Delgocitinib cream, lidocaine cream, Lidocaine+Delgocitinib
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pruritus, Chronic Urticaria
Safety Study of Levocetirizine and Fexofenadine
This Study is to comparison of Efficacy and Consistency of Action of Levocetirizine 5 mg once daily with Fexofenadine 60 mg twice daily in the histamine induced wheal, flare and itch Response.
- Conditions
- Pruritus, Chronic Urticaria, Allergic Rhinitis
- Trial name
- LAWAF (NCT01586091)
- Testing
- Levocetirizine Oral Tablet, Fexofenadine 60 Mg Oral Tablet
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Cutaneous Manifestations, Skin Manifestations
Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
An outbreak of Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-coV-2) occurred in Wuhan city, Hubei province, China in December 2019.
- Conditions
- Cutaneous Manifestations, Skin Manifestations, COVID-19, COVID-19 Pneumonia
- Trial name
- NCT05094687
- Where
- Pakistan
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
ITCH
Pain Sensitivity and Pruritus of Peripheral Nerves
Previous research has demonstrated that itch and pain share several underlying neural pathways and signaling molecules. Understanding these common mechanisms is important for developing more effective therapeutic strategies…
- Trial name
- NCT07887906
- Testing
- Mepyramine cream, Histamine Dihydrochloride (HDC), Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University