Clinical trials: Proteomics
Peri-implant Tissue Healing Assessed by Proteomic Analysis
Multicentre Study on the Impact of Transmucosal Abutment Surface Characteristics on Peri-implant Tissues.
The main objective of the study is to perform proteomic adsorption analysis on machined (grey) and anodised (pink) surfaces and compared them.
- Trial name
- NCT07246499
- Testing
- Pink anodized implant abutment., Grey machined implant abutment.
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- University of Valencia
Kidney Transplantation, Graft Rejection
Mass Spectrometry-based Proteomics in Microvascular Inflammation Diagnosis in Kidney Transplantation.
Microvascular inflammation, the hallmark histological criteria of antibody-mediated rejection in kidney transplantation, remains an issue in routine practice, due to a lack of reproducibility in its recognition by pathologists…
- Conditions
- Kidney Transplantation, Graft Rejection, Humoral Immunity, Proteomics
- Trial name
- TranSpec (NCT04851145)
- Testing
- Mass spectrometry-based proteomics of FFPE biopsies and urine samples
- Where
- 3 sites in France
- Volunteers
- 141 people
- Sponsor
- University Hospital, Bordeaux
Cardiac Arrest (CA), Proteomics
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy
Cardiac arrest remains a large contributor to morbidity and mortality. Animal studies suggest an improvement in mortality and neurological function with hypothermia after cardiac arrest, a finding that could not be verified in…
- Trial name
- NCT07017374
- Testing
- Proteomic analysis, targeted temperature management
- Where
- Sweden
- Volunteers
- 682 people
- Sponsor
- Region Skane
Hypertension, Exercise Training
Reducing Heart Failure Risk in Late-Life With Physical Activity
The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise.
- Conditions
- Hypertension, Exercise Training, Cardiac Rehabilitation, Proteomics
- Trial name
- NCT06247774
- Testing
- Cardiac Rehabilitation, Attention Control
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Saliva, Oral Lichen Planus
Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics
The goal of this observational study is to compare salivary proteome profiles in patients with Oral Lichen Planus (OLP), Oral Leukoplakia (OL), and healthy individuals without oral mucosal disease.
- Conditions
- Saliva, Oral Lichen Planus, Oral Leukoplakia, Proteomics
- Trial name
- NCT07416318
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Colorectal Cancer (CRC), Neoadjuvant Therapy
Using 4D Urinary Proteomics to Predict and Evaluate Treatment Response in Colorectal Cancer
The goal of this observational study is to learn how well urinary proteins can predict treatment response in patients with locally advanced colorectal cancer (LACC) undergoing neoadjuvant therapy.
- Conditions
- Colorectal Cancer (CRC), Neoadjuvant Therapy, Proteomics
- Trial name
- NCT06904677
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Epilepsy, Microbiota
EPIGUT: EPILEPSY AND GASTROINTESTINAL MICROBIOTA: UNDERSTANDING THERAPY RESPONSE
The goal of this observational study is to learn how the bacteria in the gut and mouth (called the microbiota) are linked to different types of epilepsy and how they may affect how well seizure medicines work.
- Conditions
- Epilepsy, Microbiota, Proteomics, Metabolomics
- Trial name
- EpiGUT (NCT07253701)
- Where
- 6 sites in Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Lactate, Sports Performance
Association Between Training Load and Lactate and Other Metabolites Analyzed by Metabolomic and Proteomic Techniques
Physical exercise induces numerous changes in the body in a complex signalling network caused by or in response to increased metabolic activity of contracting skeletal muscles.
- Conditions
- Lactate, Sports Performance, Metabolomics, Proteomics
- Trial name
- PROTEOMET (NCT06365320)
- Testing
- Single basketball training
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Neurosyphilis, Biomarkers
Cohort-Based Study of Diagnostic Biomarkers for Neurosyphilis
The goal of this observational study is to identify diagnostic biomarkers for neurosyphilis in patients with the condition. The main questions it aims to answer are: What plasma biomarkers are associated with neurosyphilis? What…
- Conditions
- Neurosyphilis, Biomarkers, Proteomics
- Trial name
- NCT06680011
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Proteomics, Exercise
Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading
Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical inactivity puts people at an…
- Conditions
- Proteomics, Exercise, Atrophy, Disuse, Hypertrophy
- Trial name
- HYPAT (NCT04514744)
- Testing
- Knee bracing, Unilateral Resistance Exercise Training
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetes Type 1, Proteomics
Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)
The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic…
- Conditions
- Diabetes Type 1, Proteomics, Diabetic Peripheral Neuropathy
- Trial name
- PAPD (NCT04257877)
- Testing
- Blood sampling
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Hypertension, Renal Denervation
The Predictive Role of Proteomics in Blood Pressure Response of Hypertensive Patients Undergoing Renal Denervation.
Renal sympathetic nervous activity plays a crucial role in the development and maintenance of hypertension (HTN). Renal denervation (RDN) is a minimally invasive catheter-based treatment using mainly radiofrequency or ultrasound…
- Conditions
- Hypertension, Renal Denervation, Proteomics
- Trial name
- PREDICT-RDN (NCT06208501)
- Testing
- Urine sample for proteomic analysis, ABPM, OBPM
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Hippocration General Hospital
Prediabetes, Diabetes Mellitus
Research on Potential Biomarkers of Prediabetes and Diabetes Based on MALDI-TOF MS Platform.
Through the MALDI-TOF MS platform, explore the proteomics and peptidomics differences of fasting serum/plasma and urine between non pregnant people with normal glucose tolerance test and prediabetes /diabetes patients, pregnant…
- Conditions
- Prediabetes, Diabetes Mellitus, Gestational Diabetes Mellitus, Proteomics
- Trial name
- NCT06097065
- Testing
- Oral Glucose Tolerance Test
- Where
- China
- Volunteers
- 2,860 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Proteomics, Pancreatic Cancer
Prognostic Biomarkers of Pancreatic Cancer Based on Proteomic Techniques
Sequence I (Retrospective study: proteomic analysis of pathological specimens and information collection of previous patients with pancreatic cancer) Sequence 2 (Non-interventional prospective study, sample and information…
- Conditions
- Proteomics, Pancreatic Cancer, Prognostic Biomarkers
- Trial name
- NCT05289895
- Testing
- No intervention
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Lipoprotein Metabolism, PCSK9
Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults
Background: Metabolism is what the body does to turn food into energy. Omega-3 fatty acids are substances found in foods such as cold-water fish and shellfish that are essential for good health.
- Conditions
- Lipoprotein Metabolism, PCSK9, Proteomics
- Trial name
- NCT02514070
- Testing
- EPA-rich fish oil, DHA-rich fish oil
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Tumor Tissues and Non-tumor Tissues From PDAC Patients Were Used for Genomic and Transcriptome Sequencing Analysis and Proteomics and Phosphorylated Proteomics
Integrative Proteomic Characterization of Pancreatic Ductal Adenocarcinoma
A large-scale, high-throughput, multi-dimensional comprehensive study of PDAC multiomics will be carried out. In this study, clinical specimens of resected PDAC collected by our research group from 2017 to 2019 will be selected…
- Trial name
- NCT04525209
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Lipoprotein Metabolism, PCSK9
Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults
Background: Fish oils are known to be beneficial to health and believed to be cardio-protective. Omega-3 fatty acid is the most known fish oil available in the market.
- Conditions
- Lipoprotein Metabolism, PCSK9, Proteomics
- Trial name
- NCT03043365
- Testing
- control fish oil, LCMUFA-rich saury oil
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Osteosarcoma, Proteomics
Proteomics Research of Osteosarcoma
Retrospectively collected 400 cases of clinical data and pathological paraffin specimens of osteosarcoma, chondrosarcoma (control) and endogenous chondroma (control) in our hospital from 2008 to 2014, combined with high-pressure…
- Trial name
- PROS001 (NCT03932058)
- Testing
- Chemotherapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Adipose Tissue, Brown Adipose Tissue
Cold Induced Activation of Brown Adipose Tissue in Winter Swimmers
This study investigates cold-induced brown fat activation in winter swimmers and not-winter swimmers by skin temperature measures assessed with infra red thermography imaging and skin temperatures.
- Conditions
- Adipose Tissue, Brown Adipose Tissue, Brown Fat, Uncoupling Protein 1
- Trial name
- COLDBAT_WS (NCT03095846)
- Testing
- Cooling
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet