Clinical trials: Proteome
Pelvic Organ Prolapse, Hysterectomy
Evaluation of the Relationship Between Vaginal and Lower Urinary Tract Microbiomes and Infection After Hysterectomy
The purpose of this study is to learn more about the microbes (bacteria) that live in the vagina and the bladder. The investigators are doing this research study to understand the relationship between microbes (the microbiome)…
- Conditions
- Pelvic Organ Prolapse, Hysterectomy, Urinary Tract Infection
- Trial name
- NCT02751073
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Skeletal Muscle Physiology
Proteome Remodelling
The purpose of the project is to investigate the proteome signature dynamics and remodelling in human skeletal muscle induced by exercise training
- Trial name
- NCT04136457
- Testing
- Endurance training, Resistance training, Sprint training
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Aging
Protein Quantity and Quality in Older Subjects
After the age of ~50, humans start to lose muscle mass at a rate of about 1-3% per year. However, the loss of muscle mass beyond a certain point can make it increasingly difficult to perform activities of daily living such as…
- Trial name
- NCT05301179
- Testing
- Protein quantity and quality
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Elderly Patients, Chronically Ill
Sub-study of the Essen Study Centre for the ENTAiER Trial
The present study is a sub-study of the ENTAiER study. The ENTAiER study is a multicenter, randomized, controlled study to evaluate the efficacy and safety of eurythmy therapy and Tai Chi in comparison to standard care in…
- Conditions
- Elderly Patients, Chronically Ill, Increased Risk of Falling
- Trial name
- NCT04532073
- Testing
- Eurythmy Therapy, Tai Chi, Standard Care
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universität Duisburg-Essen
Cancer
Pilot Study of Biomarkers for Radiation Therapy
The purpose of this study is to determine whether specific assays of DNA damage repair proteins can be used in patients undergoing radiation therapy.
- Trial name
- NCT01050725
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Benaroya Research Institute
Healthy
Effect of Exercise on Muscle Proteome Signature
The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men
- Trial name
- NCT03270475
- Testing
- exercise training
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Periodontitis
Salivary Proteome in Response to Non-surgical Periodontal Treatment
This study aims to investigate salivary proteome changes in periodontitis patients before and after non-surgical treatment. Ten systemically healthy and non-smoker individuals with stage III, grade C periodontitis underwent…
- Trial name
- NCT05952895
- Testing
- Conventional quadrant-wise scaling and root planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Inherited Platelet Disorders
Use of Proteomics for the Diagnosis of a Platelet-related Bleeding Disorder
The goal of this study is to identify the platelet defect responsible for the bleeding in families from our inherited platelet disorders Israeli-Palestinian registry.
- Trial name
- NCT02096523
- Testing
- Blood collection for platelet protein samples
- Where
- Israel
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Ela Shai
Statin Induced Proteinuria
Statins and the Urinary Proteome
This study aims to investigate whether statines (rosuva- and pravastatin) induce tubular proteinuria.
- Trial name
- NCT00464503
- Testing
- Rosuvastatin-Crestor, Pravastatin-Pravasine
- Where
- Belgium
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Peri-implantitis, Periodontitis
Transcriptome, Proteome and Microbiome Profile in Periodontal and Peri-implant Diseases
1. To investigate the transcriptomic profile of periodontitis and peri-implantitis. Patients with defined periodontitis, at two non-adjacent teeth and peri-implantitis at ≥ one implant in function of ≥ one year, will be included…
- Trial name
- NCT06262035
- Testing
- Periodontitis and Peri-implantitis
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Cardiovascular Disease
The Effects of Trout Fed With a Vegetable Based Feed on Cardiovascular Risk Markers and Plasma Proteome
Fish from the aquaculture sector constitutes an increasing part of the fish consumption in Denmark. The most important farmed fish in Denmark is the rainbow trout.
- Trial name
- NCT00445614
- Testing
- Effects of trout on CVD risk markers and plasma proteome
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cardiovascular Disease
Dark Chocolate and Platelet Function in Humans
Cardiovascular disease is a major cause of mortality worldwide and responsible for one out of three global deaths. A main characteristic of cardiovascular disease is impaired blood flow and formation of blood clots.
- Trial name
- NCT01099150
- Testing
- Dark chocolate enriched in flavan-3-ols and procyanidins, Standard dark chocolate, White chocolate
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Retinal Vein Occlusion
Aqueous Humor Proteome in Retinal Vein Occlusion With Macular Edema
the goal of this observational study is to the find the molecular mechanisms underlying the prognosis process of Retinal vein occlusion in patients with retinal vein occlusion .
- Trial name
- NCT07106268
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Eye Hospital
Allergic Rhinoconjunctivitis
Nasal Mucus Proteome and Immunotherapy
Nasal mucus as first line defense barrier of the nasal mucosa contains a variety of proteins that act as functional units. We recently showed that the nasal mucus proteome between allergic rhinitis patients and healthy controls…
- Trial name
- NCT02159404
- Testing
- Immunotherapy
- Where
- Austria
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Coronary Artery Disease, Coronary Arteriosclerosis
Influence of EPICardial Adipose Tissue in HEART Diseases: EPICHEART Study
This translational study was designed to explore the association of the quantity and quality of epicardial adipose tissue (EAT) with coronary artery disease (CAD), left atrial remodeling and postoperative atrial fibrillation in a…
- Conditions
- Coronary Artery Disease, Coronary Arteriosclerosis, Atrial Fibrillation, Left Atrial Abnormality
- Trial name
- EPICHEART (NCT03280433)
- Testing
- Aortic valve replacement
- Where
- 2 sites in Portugal
- Volunteers
- 500 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Healthy
Salivary Proteome and Sensitivity to Bitterness
This study aims to establish whether the protein composition of healthy males contribute to their sensitivity to the bitterness of caffeine.
- Trial name
- PROTAMER (NCT01079338)
- Testing
- caffeine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Rhabdomyosarcoma
Identification of Specific Molecular Signatures in Pediatric, Adolescent, and Young Adult Rhabdomyosarcoma Through Spatial Proteome Analysis Using Mass Spectrometry
This non-interventional study aims to develop spatial proteomics for analyzing small FFPE tumor samples in rhabdomyosarcoma. It will identify molecular signatures linked to tumor regions, subtypes, survival, and treatment…
- Trial name
- AERO-RMS (NCT06924463)
- Testing
- None AHT
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Lille University
Transfusion-Related Acute Lung Injury, ARDS, Human
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples
Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population.
- Trial name
- CURIE (NCT06444750)
- Testing
- Blood sample collection
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Uveitis, Vasculitis
The Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease
This study will examine the proteins of people with uveitis, or inflammation of the eyes. Evaluating the vitreous, the colorless transparent substance that fills the eyeball in back of the lens, is now possible with the use of…
- Conditions
- Uveitis, Vasculitis, Ocular Inflammatory Disease
- Trial name
- NCT00331331
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- National Eye Institute (NEI)
Neoplasm Metastasis
Proteome-based Immunotherapy of Lung Cancer Brain Metastases
Trial Hypothesis: Acute, progressing lethal neurooncological process can be transferred into chronic and non-lethal, the survival rates and life quality can be improved by of control of tumor cells (TCs) quantity and targeted…
- Trial name
- NCT01782287
- Testing
- Dendritic vaccine, allogeneic hematopoietic stem cells, cytotoxic lymphocytes, Dendritic vaccine, autologous hematopoietic stem cells, cytotoxic lymphocytes
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- NeuroVita Clinic