Clinical trials: Prosthetic Valve Endocarditis
Infective Endocarditis, Heart Failure
Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft
: Evidence suggested that autologous or allogeneic tissue is more suitable to synthetic material in an infected field. Given the unwillingness of some surgeons to use artificial foreign materials, such as conventional mechanical…
- Trial name
- IESCOPHO (NCT05253469)
- Testing
- Cryopreserved Aortic Homograft, Stented/Non stented xenograft, Mechanical prostheses
- Where
- France
- Volunteers
- 760 people
- Sponsor
- Centre Cardiologique du Nord
Mycobacterium Chimaera Infections
Prosthetic Valve and Graft Endocarditis With Mycobacterium Chimaera
Mycobacterium chimaera infections have occurred in post-cardiac surgery patients in association with contaminated cardiac bypass heater-cooler devices. So far optimal therapeutical concepts are not clear.
- Trial name
- NCT04429256
- Testing
- data collection
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University Hospital, Basel, Switzerland
Endocarditis, Bacterial, Endocarditis
Effectiveness of Antibiotic Prophylaxis of Infective Endocarditis for Invasive Dental Procedures in Patients With Prosthetic Heart Valves and/or History of Infective Endocarditis
Infective endocarditis (IE) continues to cause serious morbidity and mortality. To reduce its incidence, antibiotic prophylaxis has been recommended before invasive dental procedures in patients with at risk predispositions.
- Conditions
- Endocarditis, Bacterial, Endocarditis, Endocarditis Acute and Subacute
- Trial name
- PROPHETS (NCT05613933)
- Testing
- Improved practices
- Volunteers
- 250,000 people
- Sponsor
- University Hospital, Bordeaux
Infective Endocarditis
Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis
The primary objective of this study is to demonstrate that a rifampin-free regimen is non-inferior to the rifampin-containing regimen in terms of all-cause mortality in staphylococcal prosthetic valve endocarditis within 6 months…
- Trial name
- RIFREE (NCT07345325)
- Testing
- Rifampin-free regimen, Rifampin containing regimen
- Where
- 31 sites in France
- Volunteers
- 422 people
- Sponsor
- Nantes University Hospital
Staphylococcus Aureus Endocarditis, Prosthetic Valve Endocarditis
Adjunctive Rifampin for the Treatment of Prosthetic Valve Endocarditis Due to S. Aureus
This is a sub-study of the S. aureus Network Adaptive Platform (SNAP) trial (NCT05137119) wherein we will evaluate whether not giving rifampin in patients with probable or definite prosthetic valve endocarditis due to S.
- Trial name
- RIFA-SNAP (NCT07253688)
- Testing
- Rifampin, No rifampin
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Todd C. Lee MD MPH FIDSA
Endocarditis
Suppressive Antibiotic Therapy for Endocarditis
Endocarditis are deadly infections, which nowadays occurs mainly among older patients with multiple comorbidities. The incidence is notably high among patients with valvular prosthetic or implantable devices.
- Trial name
- SATIE (NCT06107309)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Prosthetic Valve Endocarditis
Evolution of PET Fixation With FDG at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis
In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether FDG-PET is able to identify…
- Trial name
- EndEOTEP (NCT05989152)
- Testing
- FDG-PET at the end of treatment for IE
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prosthetic Valve Endocarditis
Prosthetic Valve Sweing Ring Injection by Antiboitics Can Affect the Rate of Postoperative Infective Endocarditis?
Follow-up of patients undergoing cardiac valve replacements with prosthetic valve after injection of sewing ring of prosthetic valve with aminoglycoside for prevention of infective endocarditis.
- Trial name
- NCT05455788
- Testing
- Aminoglycoside
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bioprosthetic Valve Failure, Prosthetic Heart Valve Dysfunction
REVIVE-FR Registry
This registry aims to investigate treatment options for patients whose previously implanted biological aortic heart valve no longer functions properly.
- Conditions
- Bioprosthetic Valve Failure, Prosthetic Heart Valve Dysfunction, Structural Valve Deterioration, Prosthetic Heart Valve Thrombosis
- Trial name
- NCT07885761
- Testing
- TAVI-in-SAVR (Valve-in-Valve), THV-in-THV (Redo-TAVI), Surgical Explantation of a Failed Transcatheter Heart Valve
- Volunteers
- 200 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Infective Endocarditis
Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis
CiGal-EI-TEP is an exploratory study that aim to assess the diagnostic performance of 68Ga Positron emission tomography (PET) / Computed Tomography (CT) for the diagnosis of prosthetic valve infective endocarditis in comparison…
- Trial name
- CiGal-EI-TEP (NCT05446376)
- Testing
- 68Ga-citrate PET/CT
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Bordeaux
Prosthetic Valve Endocarditis (PVE)
Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis
The diagnosis of prosthetic valve endocarditis (PVE) remains challenging. In PVE cases, initial echocardiography is normal or inconclusive in almost 30% of cases, leading to a decreased diagnostic accuracy for the modified Duke…
- Trial name
- NCT01916005
- Testing
- 18F-FDG PET/CT
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Endocarditis
The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials
Infectious endocarditis is a serious pathology with difficult diagnosis especially on prosthetic valves or cardiac device because of the plurality of clinical presentations and the low sensitivity value of echocardiography in…
- Trial name
- PLEIM (NCT03112356)
- Testing
- 99mTc-Leukoscan® scintigraphy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon