Clinical trials: Prosthetic
Dental Implants
Study Evaluating the Performance and Safety in the Medium and Long Term of Global D ZygoFixU System
Global D has developed an zygomatic implant prosthetic system (ZygoFixU range): zygomatic implants, prosthetic parts and associated instruments.
- Trial name
- NCT06960460
- Testing
- Dental implant surgery with ZygoFixU implants
- Where
- 3 sites in France, Italy
- Volunteers
- 99 people
- Sponsor
- Global D
Lower Limb Amputation Below Knee (Injury)
R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment
Lower limb amputees (LLA) rely on their prosthetic legs to remain active and lead an independent life. For most LLAs, a well-fitted prosthetic socket is the only option to interface with their prosthetic leg, however, it is a…
- Trial name
- ENABLE (NCT05425810)
- Testing
- Apply ENABLE sensing pad, Insert small pads at pressure tolerant locations
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- North Carolina State University
Acute Myocardial Infarction, Unstable Angina
PERcutaneouS Coronary intErventions in Patients Treated With Oral Anticoagulant Therapy
Approximately 5 to 8% of patients undergoing percutaneous coronary interventions requires chronic anticoagulant therapy due to atrial fibrillation or other clinical entities.
- Conditions
- Acute Myocardial Infarction, Unstable Angina, Chronic Stable Angina
- Trial name
- PERSEO (NCT03392948)
- Where
- 10 sites in Italy
- Volunteers
- 1,080 people
- Sponsor
- Italian Society of Invasive Cardiology
Dental Prosthesis Failure
RCT: Titanium vs FCZ vs Zirconia Framework
In recent years, zirconia-based implant-supported bridge designs have begun to be used more and more as an alternative to metal ceramic bridges.
- Trial name
- NCT05296291
- Testing
- High-translucent monolithic zirconia Bridge, Zirconium oxide ceramics Framework, Metal-ceramic Framework
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Branemarkkliniken
Lower Limb Amputation Below Knee (Injury)
Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss
This study evaluates brain neuroplasticity and functional performance in people with unilateral lower limb amputation.
- Trial name
- HumanIT (NCT05818410)
- Testing
- Prosthetic device (Lunaris), No prosthetic device, Prosthetic device (Sach foot)
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Thrombosis
Anticoagulation Regiments in Patients With Prosthetic Heart Valve Thrombosis
Prosthetic valve thrombosis is a serious complication with high mortality and morbidity. However, the best anticoagulant treatment strategies for patients with prosthetic heart valve thrombosis have not been fully known.
- Trial name
- NCT02240953
- Testing
- Warfarin, Warfarin + ASA 100 mg + PPI, Warfarin + ASA 300 mg + PPI
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Amputation Stumps, Amputees
Moisture Management Liner Effectiveness Study
The comfort and fit of the residual limb within a prosthetic socket are of primary concern for many amputees. The residual limb is typically covered by non-breathable and non- thermally conductive materials that can create a warm…
- Conditions
- Amputation Stumps, Amputees, Amputation, Lower Limb Deformities, Congenital
- Trial name
- NCT04427007
- Testing
- Moisture Management Liner, Control Liner
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Women's-Specific Footwear With Prosthetic Feet
The purpose of this study is to address footwear challenges unique to women prosthesis users. Comparing the effectiveness of different footwear and prosthesis combinations will help guide clinical decision making regarding the…
- Trial name
- WSF (NCT03673371)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Aortic Stenosis, Disorder of Prosthetic Cardiac Valve
Biomarkers in Aortic Stenosis - B.A.S.S.
This study is being done to determine whether or not new blood test(s) can determine the severity of heart conditions. Aortic stenosis, hypertrophic cardiomyopathy, mitral regurgitation, aortic regurgitation, artificial heart…
- Conditions
- Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- BASS (NCT01334801)
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Amputation
Assessment of a Hybrid Pump for Vacuum Suspension of Prosthetic Sockets for Persons With Lower Limb Loss to Characterize the Effects of Added Movement on Socket-reaction Torques
Prostheses can be suspended from the amputated limb using a variety of techniques, such as straps and suction. Suspending the prosthesis by creating a vacuum between the prosthetic socket and limb using a pump has benefits over…
- Trial name
- HIPPI (NCT04230512)
- Testing
- Pump prototype
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Marginal Bone Level Change
A Clinical Study on Implants With TiUltra Technology and Associated Prosthetic Components
This is a multicenter, prospective, non-interventional study in which a total of 1000 subjects in need of a single, multiple or full arch restoration in any region of the mouth (healed or extracted) will be treated in up to 30…
- Trial name
- NCT04737421
- Testing
- NobelActive TiUltra implant, NobelParallel CC TiUltra implants, NobelReplace CC TiUltra implants
- Where
- 32 sites in United States, Australia and 12 more
- Volunteers
- 1,000 people
- Sponsor
- Nobel Biocare
Prosthetic Joint Infection, Severe Infection
Phage Safety Cohort Study
This cohort study aims to describe the adverse events related to the use of bacteriophages to treat serious infections, data from the literature being almost non-existent on this subject.
- Trial name
- PHA-SA-CO (NCT04650607)
- Testing
- Adverse event after injection of phages
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Breast Reconstruction
Comparing Two Different Surgical Techniques for Breast Reconstruction
The purpose of this study is to compare two standard techniques for breast reconstruction-the prepectoral technique and the subpectoral technique.
- Trial name
- NCT04716959
- Testing
- Prepectoral Prosthetic Breast Reconstruction, Subpectoral Prosthetic Breast Reconstruction
- Where
- 7 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prosthetic Joint Infections of Hip, Staphylococcus Aureus Infection
Bacteriophage Therapy for Methicillin-Sensitive Staphylococcus Aureus Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage cocktail to treat and prevent the recurrence of a methicillin-susceptible Staphylococcus aureus prosthetic joint infection…
- Trial name
- PHAGE-2024-01 (NCT06456424)
- Testing
- Phage therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Amputation Stump
Effect of Early Prosthetic Fitting in Patients With Below-knee Amputation
A randomized control trial of 50 patients to identify the effect of early prosthetic fitting and physical rehabilitation. Previous studies show a significant impact of early induction of prosthetic rehabilitation of amputation.
- Trial name
- NCT06457659
- Testing
- Early Rehab Group, Delayed Rehab Group
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Superior University
Staphylococcus Aureus, Prosthetic Joint Infection
ARTHR-IS (Arthroplasties' Infections Due to Staphylococcus Aureus)
The number of arthroplasties is expected to grow in the next few years. Staphylococcus aureus (SA) is a primary cause of prosthetic joint infection (PJI) with serious consequences.
- Conditions
- Staphylococcus Aureus, Prosthetic Joint Infection, Arthroplasty Complications
- Trial name
- NCT03826108
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Lower Limb Amputation Below Knee, Diabetes (DM)
Skin Temperature Perception and Prosthetic Thermoregulation
To protect against excessive body temperatures, local thermoregulatory mechanisms include temperature sensory nerves (responsive to warm or cool stimuli) and vasomotors (muscles that constrict or dilate blood vessels).
- Conditions
- Lower Limb Amputation Below Knee, Diabetes (DM), Skin Temperature Change, Vascular Reactivity
- Trial name
- NCT07215442
- Testing
- Warming stimulus starting at 30 C initial temperature, Warming stimulus starting at 32 C initial temperature, Warming stimulus starting at 34 C initial temperature
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- VA Puget Sound Health Care System
Periprosthetic Fracture Around Prosthetic Joint Implant Knee
Weight-Bearing CT Periprosthetic Distal Knee Fractures
Total knee arthroplasty (TKA), a knee implant surgery, is a treatment for end-stage knee osteoarthritis. In some cases, patients suffer an associated periprosthetic fracture, a broken bone that occurs around the implant of a TKA…
- Trial name
- NCT06525610
- Testing
- Periprosthetic Fracture Knee Repaired CT Scans
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Aortic Valve Disease
4D- Flow- MRI After Aortic Valve Surgery
This randomized controlled trial was designed to analyze flow patterns in the ascending aorta with MRI after either Trileaflet reconstruction of the aortic valve with autologous pericardium (TriRec) or surgical valve replacement…
- Trial name
- NCT04223713
- Testing
- TriRec, Aortic valve replacement
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Bone Loss
Prosthetic Modality and MBL
The present study will test the effect of different prosthetic modalities on conical and internal hex connection implants, assessing the radiographic MBL changes after one year.
- Trial name
- NCT07156110
- Testing
- Traditional prosthetic procedure, one abutment-one time
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo