Clinical trials: Prospective
Myasthenia Gravis
A Prospective Cohort Study of Myasthenia Gravis in China
The goal of this prospective cohort study is to investigate long-term therapeutic strategies for myasthenia gravis (MG) and identify potential biomarkers. The main questions it aims to answer are: 1.
- Trial name
- NCT06006832
- Testing
- Steroid Drug, Withdraw all immunosuppresants
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Peking Union Medical College Hospital
Infertility, Infertility Assisted Reproductive Technology
A Large-scale, Prospective Cohort Study Was Conducted to Explore the Association Between Environmental Exposure and Behavioral Factors and Infertility (the Success Rate of Assisted Reproductive Technology)
The aim is to explore the reasons for the failure of assisted reproductive technology (ART) in infertile patients in Hunan Province and seek ways to improve the success rate of ART.
- Conditions
- Infertility, Infertility Assisted Reproductive Technology, Infertility (IVF Patients)
- Trial name
- NCT07641387
- Testing
- Life Style Intervention, Environmental exposure
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Hematological Malignancies, Stem Cell Transplantation
A Prospective Registry for Febrile Events in Patients With Malignant Hemopathies or Subjected to Haematopoietic Stem Cell Transplant
Hema e-chart is an electronic case record that can be changed in real time and is based on the chronological organisation of the infective events and the therapies prescribed.
- Trial name
- HEMA E-CHART (NCT01069887)
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Catholic University of the Sacred Heart
Oncology
The Internal Prospective Validation of the Cancer Admission Score (CAS) Prediction Model
The goal of this single center prospective observational study is to determine the agreement between the cancer admission score (CAS) predicted disposition and the actual disposition in patients with an active cancer diagnosis…
- Trial name
- ONCOMING (NCT06558487)
- Testing
- Cancer Admission Score Prediction Model
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Radiation Therapy Boost Before Surgery for the Treatment of Non-metastatic Breast Cancer
This phase II trial investigates the safety of delivering a part (boost) of radiation treatment before breast surgery in treating patients with breast cancer that has not spread to other places in the body (non-metastatic).
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
- Trial name
- NCT04871516
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Radiation Boost
- Where
- 11 sites in United States
- Volunteers
- 103 people
- Sponsor
- Rutgers, The State University of New Jersey
Anterior Cruciate Ligament Injuries, Knee Injuries
Graft Type and Outcomes After ACL Reconstruction in Female Athletes
This prospective multicenter cohort study aims to compare clinical and functional outcomes between hamstring tendon and quadriceps tendon autografts in anterior cruciate ligament (ACL) reconstruction in female athletes.
- Trial name
- LCA-WOMEN (NCT07722104)
- Testing
- Hamstring tendon autograft ACL reconstruction, Quadriceps tendon autograft ACL reconstruction
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Thoracic Cancer
Thoracic Surgery by the Medtronic Hugo™ Robotic System
The introduction of robot-assisted surgery is one of the biggest breakthroughs in surgery, and represents the most significant advancement in minimally invasive surgery of recent decades.
- Trial name
- NCT06669104
- Testing
- Medtronic Hugo™ surgical robotic system
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus
A Clinical Efficacy and Safety Study of Insulin Glargine U300 in Chinese Adult Patients With Uncontrolled Type 2 Diabetes Mellitus With a 3-month Extension Period
This is a prospective, interventional, single arm, multicenter, phase 4 study to evaluate the clinical efficacy and safety of initiating Insulin glargine U300 in insulin-naive patients or switching from any other basal insulin to…
- Trial name
- INITIATION (NCT05002933)
- Testing
- Insulin glargine 300 U/ml
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Sanofi
FSHD1, FSHD2
Longitudinal Study on Diaframmatic Ultrasound in FSHD Patients
The goal of this prospective, longitudinal, single-center study is to describe respiratory function in patients affected by FSHD at baseline and after one year using both diaphragmatic ultrasound and pulmonary function test.
- Trial name
- NCT06078852
- Testing
- Diaphragmatic ultrasound, Pulmonary function test
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Malignant Colonic Obstruction, Colorectal Cancer
Colonic Stenting With Elective Surgery Versus Emergency Surgery in the Management of Acute Malignant Colonic Obstruction
The use of colonic stenting with elective surgery has been suggested as an alternative management for acute malignant colonic obstruction, as emergency surgery has a high risk of morbidity and mortality.
- Conditions
- Acute Malignant Colonic Obstruction, Colorectal Cancer, Colonic Obstruction
- Trial name
- NCT01997684
- Testing
- Colonic Stenting with Elective Surgery, Emergency Surgery
- Where
- 9 sites in China
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic Hepatitis B
Switch or Sequential Combination Therapy of Peginterferon in Hepatitis B Patients With Longterm Entecavir Therapy
This is a multicenter, prospective cohort study to evaluate the efficacy and safety of sequential combination or switch therapy of pegylated interferon alfa-2a in chronic hepatitis B patients with low HBsAg and HBeAg titers after…
- Trial name
- NCT02589652
- Testing
- Pegylated interferon alfa-2a, Pegylated interferon alfa-2a plus Entecavir, Entecavir
- Where
- 17 sites in China
- Volunteers
- 294 people
- Sponsor
- Huashan Hospital
Trauma
Evaluating the New Trauma Score (NTS) for Improved Mortality Prediction
The goal of this prospective cohort study is to evaluate the predictive accuracy of the New Trauma Score (NTS), a modification of the Revised Trauma Score (RTS), in determining mortality outcomes among trauma patients admitted to…
- Trial name
- NTS (NCT06732752)
- Where
- Iraq
- Volunteers
- 177 people
- Sponsor
- Al-Nahrain University
Clarify the Difference of Short-term Infection Rate Between Diffrent Catheter
Comparison of Short-term Application of Dialysis Catheter With Tunnel-cuffed Catheter Versus Non-ccuffed Catheter: a Multicenter Prospective Cohort Study
Through a multi-center, prospective cohort study, hemodialysis patients with right internal jugular vein catheterization were collected and divided into tunnel-cuffed catheter group and non-cuffed catheter group according to the…
- Trial name
- NCT06206447
- Testing
- Tunnel-cuffed Catheter, Non-ccuffed Catheter
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Friendship Hospital
Endometriosis
Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery
The purpose of the study is to compare the recurrence of endometriotic cyst in patients taking Dienogest or Microgynon after conservative surgery.
- Trial name
- NCT02385448
- Testing
- Dienogest, Microgynon
- Where
- Hong Kong
- Volunteers
- 144 people
- Sponsor
- The University of Hong Kong
Tracheal Intubation
Endotracheal Intubation Among the Critically Ill: HEMAIR Pilot Study
In order to examine the current endotracheal intubation practice among critically ill patients, a prospective observational multicenter study of adult critically ill patients was conducted from July 2015 to January 2017 involving…
- Trial name
- HEMAIR (NCT02508948)
- Where
- 16 sites in United States
- Volunteers
- 1,288 people
- Sponsor
- Mayo Clinic
Breast Cancer
Magseed Pro(R)/ Sentimag(R) Gen3
The purpose of this study is to provide prospective evidence that the Magseed Pro® marker /Sentimag® Gen3 system is safe and effective for marking A. suspicious/biopsy-proven positive axillary lymph nodes; and B.
- Trial name
- NCT05142787
- Testing
- Magseed Pro(R) and Sentimag(R) Gen3 by Endomagnetics
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 224 people
- Sponsor
- Endomagnetics Ltd.
Old Age; Atrophy, Aging
High-Speed Resistance Training Program in Independent Older Adults
The aims of the present investigation are: a) to determine the effects of a 16-weeks high-speed resistance training program on health parameters in independent older adults; and b) to verify the durability of the effects after 6…
- Trial name
- NCT05586087
- Testing
- Experimental group
- Where
- Portugal
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Évora
Dry Eye Syndromes, Dry Eye
Prospective Study To Assess The Safety And Effectiveness Of Tixel Treatment On Dry Eye Symptoms In Asian Patients
Pilot study where effect of standard Tixel treatment as used for periorbital wrinkles would be assessed on Dry Eye Disease symptoms and signs in Asian Patients.
- Trial name
- DED (NCT04260893)
- Testing
- Tixel
- Where
- Cambodia
- Volunteers
- 44 people
- Sponsor
- Novoxel Ltd.
Iliac Vein Obstruction, May-Thurner Syndrome
Vascular Ultrasound Versus Intravascular Ultrasound for Diagnosing Iliac Vein Obstruction
Determine the sensitivity, specificity and accuracy of vascular ultrasound, using direct and indirect ultrasonographic signs, in the obstructive diseases of iliac venous segment, in patients with advanced chronic venous…
- Conditions
- Iliac Vein Obstruction, May-Thurner Syndrome, Cockett Syndrome
- Trial name
- USG-DIVO (NCT02240914)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Fabio H Rossi
Parkinson's Disease
Open Label High Dose Ropinirole (Requip) Study for Patients With Parkinson's Disease
The purpose of this research study is to see if subjects with Parkinson's disease who are experiencing motor fluctuations ("on" and "off" states) and dyskinesias (involuntary excessive movements) would benefit from a higher dose…
- Trial name
- NCT00260793
- Testing
- Ropinirole Hydrochloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Agarwal, Pinky, M.D.