Clinical trials: Propofol Dosage
General Anesthesia
The Association Between Telomere Length and Propofol Dose in Anesthesia-induction
Telomeres are protein-bound DNA repeat structures at the end of eukaryotic chromosomes that are made up of a simple repetitive sequence (in humans, TTAGGG) and regulate cellular replicative capacity and cellular proliferation…
- Trial name
- NCT03429309
- Testing
- Propofol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Colonoscopy, Sedation and Analgesia
Dose-sparing Balanced Propofol Sedation in Colonoscopy
This randomized controlled trial compared two balanced propofol analgosedation strategies in adults undergoing elective colonoscopy.
- Trial name
- NCT07885059
- Testing
- Standard-dose balanced propofol analgosedation, Dose-sparing balanced propofol analgosedation
- Where
- 2 sites in Croatia
- Volunteers
- 76 people
- Sponsor
- University of Split, School of Medicine
Propofol Adverse Reaction, Anesthesia
Impact of Propofol Reduction in Anesthesia Induction
Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed between fentanyl and propofol administration, hemodynamic response is improved.
- Trial name
- NCT04194151
- Testing
- Propofol Injection
- Where
- Spain
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Hypothyroidism, Anesthesia, General
Effect of Brain GABA Metabolite Amount to Propofol Utilisation Under TIVA in Hypothyroid Patient
Introduction: GABAergic synaptic transmigration in the anterior cingulate (ACC) cortex of hypothyroid rats has been demonstrated by electrophysiologic recordings.
- Conditions
- Hypothyroidism, Anesthesia, General, Propofol Dosage, Magnetic Resonance Imaging (MRI)
- Trial name
- BrainGABA (NCT06649318)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Loss of Consciousness
The Effects of Different Doses of Dexmedetomidine on Propofol Requirement for Loss of Consciousness Undergoing Bispectral Index: a Double-blinded, Placebo-controlled Trial
The purpose of this study is to evaluate the effects of different dexmedetomidine on the propofol requirement for loss of consciousness undergoing bispectral index.
- Trial name
- NCT02783846
- Testing
- normal saline, dexmedetomidine 0.5 µg/kg, dexmedetomidine 1.0 µg/kg
- Volunteers
- 73 people
- Sponsor
- General Hospital of Ningxia Medical University
Depressive Disorder
Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy
Ketamine has been used successfully as the sole medication for anesthesia in the setting of electroconvulsive therapy (ECT), and has more recently been studied as an adjunct agent in combination with propofol (the most commonly…
- Trial name
- NCT02579642
- Testing
- Ketamine
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Alberta
General Anesthesia
Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection
Propofol is a widely used sedative anesthetic, but there are large individual differences, which making different patients with different sensitivity to propofol.
- Trial name
- NCT03422315
- Testing
- Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhongyuan Xu
Obesity, Gastrointestinal Endoscopy
Oliceridine-Propofol Dose for Gastroscope Insertion in Obese Patients
The purpose of this study is to find the right dose of two medications, oliceridine and propofol, when used together for sedation in patients with obesity undergoing a painless gastroscope procedure.
- Trial name
- NCT07759778
- Testing
- Low-Dose Oliceridine Group, High-Dose Oliceridine Group
- Volunteers
- 80 people
- Sponsor
- Lu Yi
Emergence Agitation, Rhinoplasty
Use of Subanesthetic Dose Propofol Before Extubation
This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty.
- Conditions
- Emergence Agitation, Rhinoplasty, Patient Satisfaction
- Trial name
- NCT07276633
- Testing
- Propofol (Sub-Anesthetic Dose)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yuzuncu Yil University
Anesthesia
MAPD: Modifiable Factors Affecting Propofol Dosing
The investigators aim to understand the effect of a caffeine intake, sleep habits, anxiety about surgery, alcohol intake and smoking status upon the dose of the anaesthetic drug, propofol, required for anaesthetic induction.
- Trial name
- NCT03453099
- Testing
- Preoperative Questionnaires, Postoperative Subjective Pain Scores
- Where
- United Kingdom
- Volunteers
- 91 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Anaesthetic Induction
Remifentanil Versus Sufentanil for Intubation Condition Without Myorelaxant
The main objective is the comparison of intubation conditions after anesthetic induction bolus of propofol-sufentanil when compared to injection of propofol-remifentanil in patients undergoing surgery for tooth extraction.
- Trial name
- REMIDENT (NCT01910285)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Toulouse
Knee Injuries
Nalbuphine With Remimazolam Versus Nalbuphine With Propofol for Knee Arthroscopy
This study compared two combinations of medicines used for sedation and pain relief in adults undergoing knee arthroscopy for knee joint injuries.
- Trial name
- NCT07838948
- Testing
- Nalbuphine, Remimazolam, Propofol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wuhan Fourth Hospital
Lidocaine, Injection Pain
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated With Medium-/Long-chain Triglycerides
Propofol is widely used in general anesthesia induction, but the occurrence of peripheral intravenous pain is relatively high, causing anxiety, fear and other adverse emotions in patients , aggravating the stress response, and…
- Trial name
- NCT04008433
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Drug Usage
Dexmedetomidine for Laryngeal Mask Airway Insertion
The investigators attempted to determine the optimal dose of dexmedetomidine required for the successful insertion of LMA during propofol induction without a neuromuscular blocking agent.
- Trial name
- NCT01852539
- Testing
- dexmedetomidine, propofol, laryngeal mask airway (LMA)
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Ajou University School of Medicine
Remifentanil, Analgesia
Optimal Dosage of Remifentanil for Vertebroplasty
Percutaneous vertebroplasty has become a mainstay in the management of osteoporotic and malignant vertebral fractures. Procedural analgesia and sedation (PAS) with propofol and remifentanil may provides optimal hypnotic and…
- Trial name
- NCT05876039
- Testing
- Initial remifentanil effect-site concentration
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Failed Conscious Sedation During Procedure
Magnetic Endoscope Imaging in Colonoscopy: Influence on Propofol Dosage
Magnetic Endoscope Imaging (MEI) is an optional tool which can be switched on at the beginning of colonoscopy. MEI works by creating an electromagnetic field of very low intensity.
- Trial name
- MEXICO (NCT02121704)
- Testing
- Magnetic Endoscope Imaging (Scope Guide)
- Where
- Germany
- Volunteers
- 334 people
- Sponsor
- Technical University of Munich
Pediatric Anesthesia, Airway Management
Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children
This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA)…
- Conditions
- Pediatric Anesthesia, Airway Management, General Anesthesia, LMA
- Trial name
- NCT07581665
- Testing
- Alfentanil
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Autism Spectrum Disorder
Esketamine and Propofol for Children With Autism Spectrum Disorder Undergoing Colonoscopy
The purpose of this study is to examine the dose-response relationship of esketamine in combination with propofol for children with Autism Spectrum Disorder undering colonoscopy.
- Trial name
- NCT05951465
- Testing
- Esketamine, Propofol
- Where
- China
- Volunteers
- 46 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Effect of Drug
Propofol Dose-Finding for Colonoscope Insertion in Adult Patients
The aim of this prospective dose-finding study is to determine the ED50 of propofol required for successful colonoscope insertion in adult patients. The study is designed using Dixon's up-and-down sequential allocation method.
- Trial name
- NCT07166640
- Testing
- Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Kocaeli City Hospital
Tracheal Extubation
A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients
Tracheal extubation can be associated with hyperdynamic circulatory response. The investigators examined the effect of maintaining a remifentanil infusion on the cardiovascular response during extubation in propofol-remifentanil…
- Trial name
- NCT01152515
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Severance Hospital