Clinical trials: Propofol
Sedation
Safe Administration of Propofol for Sedation in Children
Advances in health care require that more children are given sedation to allow doctors to perform investigations or minor procedures. Sedation drugs have traditionally been given orally (swallowed) by children.
- Trial name
- NCT00832013
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obesity, Bariatrics
Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy
Propofol is one of the most popular anesthetic drugs used for sedation during upper gastrointestinal endoscopies due to its quick onset and quick resolution of symptoms allowing patients to leave the hospital sooner.
- Conditions
- Obesity, Bariatrics, Sleep Apnea Syndromes, Gastric Bypass
- Trial name
- NCT02643979
- Testing
- Ketofol, Propofol, Saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cranitomy Surgery
Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery
Primary Hypothesis: The use of a Precedex infusion, in addition to propofol during surgery, will improve patient management through the anesthesia postoperative recovery period determined by improvement in patients? tolerance of…
- Trial name
- NCT00848991
- Testing
- Precedex, Propofol
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cooper Norcross Health
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Propofol Adverse Reaction, Anesthesia
Impact of Propofol Reduction in Anesthesia Induction
Objective: Determine if, by reducing the dose of propofol and increasing the time elapsed between fentanyl and propofol administration, hemodynamic response is improved.
- Trial name
- NCT04194151
- Testing
- Propofol Injection
- Where
- Spain
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Urological Disease
Breath Gas Measurement of Propofol During Anesthesia in Patients With Endourological Procedures
Propofol can be measured continuously in breath gas during anesthesia. This study compares propofol concentration in plasma and breath gas and processed electroencephalographic monitoring (bispectral index) under clinical…
- Trial name
- NCT01835340
- Testing
- Drug: Propofol Anesthesia Patients will undergo propofol anesthesia.
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Neuromuscular Monitoring
Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane
Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.
- Trial name
- NCT02711917
- Testing
- MAC 0.5, MAC 0.75, MAC 1.0
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Pain, Withdrawal
Evaluation of the Effect of Venous Diameter Measurement by Ultrasonography on Pain and Withdrawal Response
During general anesthesia, intravenous (IV) medications can disrupt the patient's comfort by causing a pain sensation or a withdrawal response in the heart.
- Trial name
- VDIAMETER (NCT03376308)
- Testing
- Pain Score, Withdrawal movement score, hemodynamic response
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Anesthesia, Sedation
A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486
This is a Phase I, single-center, open-label, randomized,two-way crossover, propofol-controlled, two-stage study evaluating the safety and pharmacokinetics/pharmacodynamics of IV maintenance dose after an initial dose and IV…
- Trial name
- NCT03745625
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
General Anesthesia, Intravenous Anesthesia
Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol
Since the introduction of propofol into routine anesthesia practice, the phenomena of pain on injection has plagued anesthesia providers. Propofol, an unstable phenol, triggers the release of bradykinin on injection.
- Trial name
- NCT01342510
- Testing
- Magnesium Sulfate, Lidocaine, Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anesthesia
Propofol-fentanyl-ketamine (PFK) Combination Versus General Anesthesia Using Propofol and Fentanyl in Patients Undergoing Endoscopic Procedures.
Conscious sedation provides adequate control of pain and anxiety for the majority of routine endoscopic procedures as well as adequate amnesia.
- Trial name
- NCT04473846
- Testing
- PK general anesthesia, PFK combination
- Where
- Jordan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Anesthesia
A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies clear the anesthetic. Most people wake quickly, but some do not.
- Trial name
- NCT03360903
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Ciprofol
Ciprofol's Influence on LVOT VTI in Elderly Painless Colonoscopy Patients
1. Objective: Primary: Compare the effect of Ciprofol vs Propofol on LVOT VTI at 2 minutes post-injection (T1) in elderly patients (≥65 years).
- Trial name
- NCT07081477
- Testing
- Intravenous Anesthetic Induction with Ciprofol for Painless Colonoscopy in Elderly Patients, Propofol Intravenous Anesthesia Induction for Painless Colonoscopy in Elderly Patients
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Lianyungang
EGD Procedure
Moderate Sedation for Elective Upper Endoscopy With Balanced Propofol Versus Propofol Alone: a Randomized Clinical Trial
Since introduction in 1989, propofol has gained wide acceptance for sedation during endoscopic procedures. The optimal sedation drug during esophagogastroendoscopy (EGD) is not established.
- Trial name
- NCT02174588
- Testing
- Midazolam + propofol, propofol
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Sedative Adverse Reaction
Evaluating the Effects of Propofol vs. Dexmedetomidine
The primary purpose of this observational study is to compare what drugs work best in sedating children (> 3 months to < 36 months) who need an MRI.
- Trial name
- NCT03552146
- Testing
- Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Anesthesia
Improving Information Extraction From EEG on Cerebral Anesthetic Drug Effects
This is an interventional, randomized controlled study in health volunteers that involves collecting data on raw EEG waves measuring various combinations of anesthetic drugs during standardized drug titration.
- Trial name
- NCT02043938
- Testing
- SedLine EEG sensor
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Propofol Overdose of Undetermined Intent
Performance Evaluation of Four Pharmacokinetic-Pharmacodynamic(PKPD) Models of Propofol in Elderly Patients
Despite the wide use of propofol target-controlled infusion (TCI) in elderly patients, pharmacokinetic (PK) and pharmacodynamic (PD) models performance has not been prospectively assessed in this population.
- Trial name
- TCIGeriatric (NCT01435785)
- Where
- 2 sites in Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
General Anesthesia
Exploratory Study of Propofol and Fentanyl Pharmacodynamics
Exploration of the hypothesis that general anesthesia is not a singular threshold but is a continuum of central nervous system depression dependent on interpretation of nociceptive stimuli.
- Trial name
- NCT01550770
- Testing
- propofol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ethicon Endo-Surgery
Colonoscopy
Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
An ideal sedative for colonoscopy should have properties that include: rapid onset and offset of action, provide cardiopulmonary stability, have minimal adverse effects, and allow for smooth recovery, and early discharge.
- Trial name
- NCT03139279
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Electroencephalography, Anesthesia
Predictive Model in EEG for Induction and Emergence in Pediatric With Propofol
Anesthesia is essential to control pain and produce unconsciousness during surgery and other procedures during childhood. The anesthetic deepness is measured indirectly through changes in blood pressure and heart rate or can be…
- Conditions
- Electroencephalography, Anesthesia, Children, Only
- Trial name
- EEGPED (NCT03705338)
- Testing
- Electroencephalography, Propofol
- Where
- Chile
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Victor Contreras, MSN