Clinical trials: Propofol
Any Patient Under General Anesthesia With Propofol Induction
A Novel Two-Step Dosing Induction Strategy (The Propofol Challenge Test) to Minimize Propofol Injection Pain
Propofol is the most widely used intravenous hypnotic agent for the induction of general anesthesia owing to its rapid onset and short duration of action.
- Trial name
- PROTECT (NCT07763548)
- Testing
- Bolus injection, Fractionned onjection
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- Erasme University Hospital
Critically Ill, Intubation Complication
Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
The aim of this retrospective cohort study is to compare the safety and efficacy of induction agents for tracheal intubation in critically ill adult patients.
- Conditions
- Critically Ill, Intubation Complication, Oxygenation, Airway Management
- Trial name
- NCT07222007
- Testing
- induction type for intubation in ICU
- Where
- United States
- Volunteers
- 806 people
- Sponsor
- Zeliha Alicikus
Conscious Sedation, Propofol
Personalized Music and Dreaming During Propofol Sedation
Many patients report dreams during intravenous (IV) propofol sedation, but it is uncertain whether listening to music changes how often dreams occur or how pleasant they feel.
- Conditions
- Conscious Sedation, Propofol, Dreams
- Trial name
- NCT07389954
- Testing
- Preferred Music, Matched Non-Preferred Music, Silence (Headphones Only)
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Wonkwang University Hospital
Chronic SSRI/SNRI Use and Intraoperative Propofol Requirements
The Effect of Chronic ssrı/snrı Antidepressant Treatment on Propofol Consumption in Elective Spine Surgery
The goal of this observational study is to learn whether long-term use of selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants is related to the amount of propofol…
- Trial name
- NCT07822295
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
MRI Sedation, Pediatric Sedation
Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging
The most common imaging procedure requiring sedation/anesthesia for the pediatric population is magnetic resonance imaging (MRI). However, the optimal anesthetic/sedation plan has not been determined for these procedures.
- Conditions
- MRI Sedation, Pediatric Sedation, Propofol Dosage, Emergence Delirium, Anesthesia
- Trial name
- NCT07369128
- Testing
- Dexmedetomidine (IV) 0.5 mcg/kg, Propofol (IV) 2-4 mg/kg, Dexmedetomidine (IV) 1 mcg/kg
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Boston Children's Hospital
Propofol Injection Pain in Children
Determining if the Buzzy® Personal Pain Relief Device Reduces Injection Pain of Propofol as Much as Intravenous Lidocaine in Children
Propofol is a drug commonly used for induction of general anesthesia in children as well as adults; however, propofol can cause pain on injection, possibly more frequently in children.
- Trial name
- NCT07770581
- Testing
- Buzzy device, Intravenous lidocaine
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
Propofol Injection Pain
Arm Elevation for Prevention of Propofol Injection Pain
The purpose of this research is to determine whether a simple technique, temporarily raising the arm during the injection of propofol (a commonly used medication for anesthesia), can reduce the pain that some people experience…
- Trial name
- NCT07785674
- Testing
- Passive arm elevation, Normal saline, Lidocaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL/min.
- Trial name
- NCT07670923
- Testing
- Propofol Injection, Ciprofol Injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- General Hospital of Ningxia Medical University
Spinal (Fusion) Surgery, Total Intravenous Anesthesia
Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider
This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients…
- Conditions
- Spinal (Fusion) Surgery, Total Intravenous Anesthesia, Target Controlled Infusion of Propofol, Anesthesia Depth Monitoring
- Trial name
- NCT07586189
- Testing
- TCI Propofol Injection Models- Eleveld, TCI Propofol Injection Schnider
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Kyphoplasty, Prone Position
TCI Versus Manual TIVA for Sedation During Prone Kyphoplasty: Effects on Respiration, Recovery, and EEG
This single-center, prospective, observational study compares target-controlled infusion (TCI) versus manually administered total intravenous anesthesia (TIVA) for sedation in patients undergoing kyphoplasty in the prone…
- Conditions
- Kyphoplasty, Prone Position, Target Controlled Infusion of Propofol, End Tidal Carbon Dioxide
- Trial name
- NCT07745348
- Testing
- Target controlled infusion of propofol, non invasive ETCO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Effect of Patient Awareness on Incidence and Severity of Propofol Injection Induced Pain
Effect Of Patient Awareness About Possibility Of Occurrence Of Pain During Propofol Injection On The Rate Of Incidence And Severity Of Pain During Injection .
Propofol is the most common intravenous (IV) anesthetic agent, used for anesthesia induction and maintenance during surgeries due to its rapid onset and short duration.
- Trial name
- No acronym (NCT05886972)
- Testing
- Awareness about propofol injection induced pain
- Where
- Egypt
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Lung Lesions, Robotic Assisted Bronchoscopy
Robotic-assisted Bronchoscopy Under Moderate Sedation With Propofol
In this study, the investigators want to find out whether robot-assisted bronchoscopy also works with moderate sedation (Propofol), as is already used in standard bronchoscopies. The study is being conducted as a pilot study.
- Conditions
- Lung Lesions, Robotic Assisted Bronchoscopy, Propofol, Bronchoscopy
- Trial name
- Robofol (NCT07006311)
- Testing
- Robotic-assisted bronchoscopy under propofol
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Comparison of the Effects of Propofol and Nasal Dexmedetomidine
Propofol vs. Nasal Dexmedetomidine in Pediatric Agitation and Delirium
Dental pain and anxiety are quite common in pediatric patients. However, due to children's inability to express their fears and lack of knowledge about the procedures to be performed, these symptoms have often been misunderstood…
- Trial name
- NCT06466915
- Testing
- Dexmedetomidine, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Remimazolam, Propofol
Remimazolam on the Incidence of Postoperative Acute Kidney Injury
We hypothesized that in patients undergoing elective hepatobiliary-pancreatic surgery, the group in which anesthesia is induced and maintained with remimazolam during surgery would maintain hemodynamic stability and reduce the…
- Conditions
- Remimazolam, Propofol, Acute Kidney Injury, Hemodynamic Stability
- Trial name
- NCT07674719
- Testing
- Remimazolam (Byfavo), propofol
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Bundang Hospital
Propofol, Anesthesia Brain Monitoring
Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison
Remifentanil is commonly used as an opioid during general anesthesia. In recent years, several pharmacokinetic/pharmacodynamic (PK/PD) models for target-controlled infusion (TCI) have been developed, with the Eleveld model being…
- Conditions
- Propofol, Anesthesia Brain Monitoring, Remifentanil
- Trial name
- TCI (NCT07259291)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Padova
Anesthesia Induction, Propofol Pain Injection
Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection.
This is a prospective, single-center, randomized, double-blind controlled trial involving patients scheduled for elective surgery requiring general anesthesia with propofol induction.
- Trial name
- NCT07632144
- Testing
- Group C (Control), Ondansetron 8 mg, Lidocaine %2 ampoule
- Where
- Tunisia
- Volunteers
- 156 people
- Sponsor
- Mongi Slim Hospital
Propofol
Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation
This study aims to compare efficacy of sedation between Dexmedetomidine-Propofol and Ketamine-Propofol combinations in the upper or lower gastrointestinal system endoscopy.
- Trial name
- NCT06756594
- Testing
- Dexmedetomidine-Propofol, Ketamine-Propofol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Sedation, Dexmedetomidine
Sedation With Dexmedetomidine or Midazolam in Combination With Propofol for Removal of Double-J Ureteral Stent
The aim of this study is to compare the efficacy of intravenous sedation using propofol alone or in combination with dexmedetomidine or midazolam for the removal of double J (D-J) ureteral stent.
- Conditions
- Sedation, Dexmedetomidine, Midazolam, Propofol
- Trial name
- NCT07580768
- Testing
- Propofol, Propofol and Dexmedetomidine, Propofol and Midazolam
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Sedation, Cataract
Dexmedetomidine and Propofol for Sedation in Cataract Surgery.
The goal of this prospective, randomized, single-blinded is to learn if there is an ideal sedation protocol in cataract surgery in adults.
- Conditions
- Sedation, Cataract, Hemodynamic, Hemodynamic Changes
- Trial name
- NCT07556133
- Testing
- Dexmedetomidine (DEX), Propofol (PRO), Fentanyl (FEN)
- Where
- Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Saint-Joseph University