Clinical trials: Prolonged Disorders of Consciousness
Consciousness Disorders
Micro-movements in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness.
- Trial name
- NCT06406413
- Testing
- micro-movement; electroencephalogram; MRI
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Prolonged Disorders of Consciousness, Tracheostomy
A Voice Valve-Based Decannulation Protoco for Patients With a Prolonged Disorders of Consciousness
To evaluate the feasibility of a standardized tracheostomy decannulation protocol for patients with prolonged Disorders of Consciousness (pDoC) .
- Trial name
- STEP-DoC (NCT07183670)
- Testing
- decannulation protocol
- Where
- 2 sites in China
- Volunteers
- 184 people
- Sponsor
- Hongying Jiang, MD
Stellate Ganglion Block, Prolonged Disorders of Consciousness
Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness
The goal of this clinical trial is to learn about the effect of preoperative administration of stellate ganglion block on postoperative sleep status in patients with prolonged disorders of consciousness.
- Conditions
- Stellate Ganglion Block, Prolonged Disorders of Consciousness, Sleep
- Trial name
- NCT07274683
- Testing
- stellate ganglion block with 0.5% ropivacaine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Beijing Tiantan Hospital
Disorder of Consciousness, Hemorrhagic Stroke
Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness
Object: To determine the effect of cerebrolysin on prolonged disorders of consciousness caused by hemorrhagic stroke. Participants: patients with prolonged disorders of consciousness due to severe traumatic brain injury…
- Trial name
- NCT04427241
- Testing
- Cerebrolysin, Control
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Konkuk University Medical Center
Consciousness Disorders, Brain Injury
Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDOC) are defined as DOC lasting >1 year post injury for patients with Traumatic Brain Injury (TBI) and >3 months post injury for patients with non-TBI and at present there are limited…
- Conditions
- Consciousness Disorders, Brain Injury, Altered Level of Consciousness
- Trial name
- NCT06930716
- Testing
- Transcutaneous vagus nerve stimulation (taVNS), Physical therapy using Hocoma, Standard of Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Consciousness Disorders
Micro-expressions in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness.
- Trial name
- NCT06088628
- Testing
- Facial expression; Electroencephalogram; MRI
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Disorder of Consciousness, Vegetative State
The Use of LIFUP in Chronic Disorders of Consciousness
When patients survive a severe brain injury but fail to fully recover, they often enter a Disorder of Consciousness (DoC) --that is, a set of related conditions of decreased awareness and arousal including the Vegetative State…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State, Minimally Conscious State Plus
- Trial name
- NCT04921683
- Testing
- BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Prolonged Disorders of Consciousness
Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDoC) are pathologies in which there is a loss of consciousness for more than 28 days. The number of patients with pDoC is increasing as the level of critical care treatment and monitoring…
- Trial name
- NCT06473285
- Testing
- Drug: Esketamine (Continuous infusion)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Traumatic Brain Injury, Concussion, Intermediate
Intervention to Change Affect Recognition and Empathy
Determine the feasibility, practicality, and early efficacy of a TeleRehab program (ICARE) to improve outcomes for persons with traumatic brain injury (TBI) in recognizing and responding to others' emotions alongside their care…
- Conditions
- Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes
- Trial name
- ICARE (NCT05636020)
- Testing
- ICARE Treatment
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Indiana University
Traumatic Brain Injury With Prolonged Loss of Consciousness
Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness of Traumatic Brain Injury
Low-intensity focused ultrasound can be effective in severe TBI patients with disorder of consciousness. This study is a prospective single arm, open-label and explorative clinical trial to evaluate the therapeutic effect of…
- Trial name
- NCT04306601
- Testing
- Low-Intensity Focused Ultrasound
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Disorder of Consciousness
Study of Brain Function Evaluation System for Acute and Prolonged Disorders of Consciousness
The research focuses on establishing a system for detecting loss of consciousness, developing clinical prognostic and awakening-related brain function testing criteria.
- Trial name
- NCT06097013
- Testing
- Routine clinical rehabilitation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Disorder of Consciousness, Comatose
Prognostication of Recovery in Early Disorders of Consciousness Study
The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of…
- Conditions
- Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State
- Trial name
- PREDICT (NCT07074678)
- Testing
- Functional MRI (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Disorder of Consciousness
A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of Consciousness
The research contains two parts. Part 1: To explore whether EEG responses to zolpidem can assess consciousness circuit integrity and predict the evolution of consciousness in patients with prolonged disorders of consciousness…
- Trial name
- NCT02948660
- Testing
- Zolpidem Tartrate Tablets
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Vegetative State, Minimally Conscious State
Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC
Previous studies showed that transcranial direct current stimulation (tDCS) transiently improves performance of motor function in stroke patients, as well as decrease muscle hypertonia.
- Conditions
- Vegetative State, Minimally Conscious State, Spasticity, Muscle, Disorder of Consciousness
- Trial name
- NCT03797573
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- University of Liege
Coma; Prolonged, Amantadine
Benefits of Amantadine in Patients With Coma State
The study was a single center observational-prospective study and approved by local ethics committee. Patients in coma state due to traumatic brain injury, cardiac arrest or ischemic stroke who are older than 18 years of age were…
- Trial name
- NCT03443037
- Testing
- amantadine sulphate
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Dokuz Eylul University
Disorder of Consciousness, Paralysis
Awareness Detection and Communication in Disorders of Consciousness
STUDY OVERVIEW Brain injury can result in a loss of consciousness or awareness, to varying degrees. Some injuries are mild and cause relatively minor changes in consciousness.
- Conditions
- Disorder of Consciousness, Paralysis, Motor Neuron Disease, Stroke
- Trial name
- NCT03827187
- Testing
- Motor imagery based EEG-BCI
- Where
- 18 sites in Ireland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Ulster
Consciousness Disorder
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials
- Trial name
- NCT05823454
- Testing
- Different drug dosage
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Disorder of Consciousness
Study of Brain Function Evaluation and Intervention System for Acute and Prolonged Disorders of Consciousness
The research focuses on establishing a system for validating the effectiveness of key technologies for targeted combined non-invasive interventions in awakening consciousness.
- Trial name
- NCT05682248
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xuanwu Hospital, Beijing