Clinical trials: Progressive Keratoconus
Keratoconus
Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking
The standard or Dresden protocol was established in 2003 and treats the entire cornea. However, recent ultra-structural research showed that keratoconus is localized.
- Trial name
- C-CROSS (NCT04532788)
- Testing
- Customized crosslinking, Standard crosslinking
- Where
- 3 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Keratoconus, Corneal Ectasia
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
- Trial name
- NCT07841470
- Testing
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Price Vision Group
Keratoconus, Pellucid Marginal Degeneration
Corneal Cross Linking and Topography Guided Excimer Laser Treatment
Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism.
- Trial name
- NCT01682993
- Testing
- Topography guided Excimer Laser treatment and Corneal Cross Linking, Corneal Cross Linking
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Keratoconus
Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus
the purpose of this study is to compare the efficacy and safety of a new method of corneal cross-linking that uses UV-A irradiation intensity of 9mW/cm2 for 7 minutes to well-known Accelerated corneal cross-linking (9 mW/cm2 UV-A…
- Trial name
- NCT02507362
- Testing
- adjusted corneal collagen cross-linking, accelerated corneal collagen cross-linking, riboflavin 0.1% combined with dextran 20 %
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Progressive Keratoconus, Corneal Ectasia
Corneal Crosslinking in Keratoconus and Corneal Ectasia
Prospective, randomized, single site to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes progressive keratoconus or corneal ectasia.
- Trial name
- CXL (NCT00679666)
- Testing
- Riboflavin
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Keratoconus
Refractive Corneal Cross-linking for Progressive Keratoconus
Young patients with keratoconus face two problems: disease progression and corneal shape irregularity. Both underlie the 20% rate of corneal transplantation in keratoconics required to maintain useful vision.
- Trial name
- NCT03531047
- Testing
- Customised CXL
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Keratoconus, Ectasia
Progressive Keratoconus or Ectasia Treatment Plan
Keratoconus and pellucid marginal degenerations are genetically based ocular conditions and post surgical ectasia is an iatrogenic condition.
- Trial name
- NCT01384773
- Testing
- Riboflavin Solution, UV-X Illumination System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stephen Trokel
Keratoconus
Variability of Pentacam-derived Back Elevation Measurements in Keratoconus and Cross-linked Corneas
Primary objective of this study was to assess the intrasession, intersession and interobserver variability of the Pentacam-derived posterior corneal elevation measurements in keratoconus eyes and eyes that underwent Corneal…
- Trial name
- NCT01471873
- Testing
- Corneal Collagen Cross-linking (CXL)
- Where
- Greece
- Volunteers
- 67 people
- Sponsor
- Democritus University of Thrace
Keratoconus
Transepithelial Corneal Collagen Crosslinking in Eyes With Progressive Keratoconus
Keratoconus is a corneal ectatic disease responsible for a loss of visual acuity when the steepening increases. Corneal collagen crosslinking (CXL) is a procedure that appears to halt or slow down the progression and avoid the…
- Trial name
- TE-CXL (NCT03584243)
- Testing
- A crosslinking with oxygen treatment
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Toulouse
Keratoconus
Standard Versus Transepithelial Corneal Crosslinking
The gold standard corneal crosslinking (CXL) technique involves the initial step of epithelial removal, in order to achieve a sufficient treatment effect (meaning: stabilisation of progressive keratoconus (KC).
- Trial name
- NCT02349165
- Testing
- Transepithelial versus epithelium-off CXL, Ricrolin TE, Isotonic riboflavin
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- Nienke Soeters
Keratoconus, Corneal Ectasia
Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin
Corneal collagen crosslinking (CXL) has been proposed as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT01152541
- Testing
- Riboflavin/Dextran, Hypotonic Riboflavin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Keratoconus
One-Year Outcomes After Conventional vs Accelerated Epi-Off Corneal Cross-Linking in Progressive Keratoconus (Observational Cohort)
Prospective, observational (consecutive eligible eyes) continuation of a previously published 6-month cohort from the same center, extending follow-up to 12 months.
- Trial name
- KCXL-1Y (NCT07194538)
- Where
- Croatia
- Volunteers
- 20 people
- Sponsor
- Clinical Hospital Centre Zagreb
Progressive Keratoconus
Safety and Efficacy of Corneal Cross-linking in Subjects With Keratoconus
Clinical Trial to Evaluate the Safety and Efficacy of Corneal Cross-linking in Subjects with Keratoconus.
- Trial name
- NCT05314738
- Testing
- NXL Energy 1, NXL Energy 2, NXL Energy 3
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Glaukos Corporation
Progressive Keratoconus
Use of a Freeze-dried Amniotic Membrane Post Crosslinking in Subjects With Progressive Keratoconus
Crosslinking is a therapeutic technique used to increase the rigidity of the cornea in order to slow or stop progression of keratoconus.
- Trial name
- NCT06450470
- Testing
- Therapeutic lens alone, Therapeutic lens + amniotic membrane (Visio-AMTRIX)
- Where
- 9 sites in France
- Volunteers
- 116 people
- Sponsor
- TBF Genie Tissulaire
Keratoconus, Corneal Crosslinking
Epi-on PiXL for the Treatment of Progressive Keratoconus.
The purpose of this study is to evaluate the efficacy, safety and postoperative ocular discomfort by individually customized Photorefractive intrastromal crosslinking (PiXL) without epithelium debridement in high oxygen…
- Conditions
- Keratoconus, Corneal Crosslinking, Corneal Densitometry, Scheimpflug Photography
- Trial name
- NCT04668924
- Testing
- Epi-on PiXL in high oxygen
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Progressive Keratoconus
Stromal Demarcation Line: is it Predictive for Cross-Linking Efficiency?
To assess the association between stromal demarcation line after collagen crosslinking (CXL) for progressive keratoconus and mid-term (6 month) refractive, topographic and clinical outcomes of CXL
- Trial name
- STROMA-CROSS (NCT02883868)
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville