Clinical trials: Progressive Disease
Upper Tract Urothelial Carcinoma
NECTAR Study: Neoadjuvant Toripalimab + 9MW2821 for Local UTUC
The NECTAR study is a multicenter, open-label, randomized phase II clinical trial designed to evaluate a neoadjuvant treatment strategy in patients with localized upper tract urothelial carcinoma (UTUC).
- Trial name
- NECTAR (NCT07412171)
- Testing
- Toripalimab, 9MW2821, Radical Nephroureterectomy with or without Lymph Node Dissection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Lung Disease
Evaluation of the Hospital2Home Palliative Care Service for Patients With Advanced Progressive Lung Disease
The investigators hypothesise that H2H will result in improved symptom control and quality of life and may be more cost-effective than standard best practice.
- Trial name
- H2H-ILD (NCT01450644)
- Testing
- The Hospital2Home Service
- Where
- 2 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Myopia
Myopia Control Efficacy of Second-generation DIMS Spectacle Lenses on Fast Progressing Myopes
The purpose of this study is to examine the efficacy and performance of the variant of Defocus Incorporated Spectacle lenses on controlling myopia progression in fast progressing myopic children.
- Trial name
- NCT05888792
- Testing
- Variant of Defocus Incorporated Spectacle lens (DG2)
- Where
- Hong Kong
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Fibromyalgia
Combined Effects of Progressive Relaxation Exercises and Aquatic Therapy in Fibromyalgia.
Fibromyalgia, a chronic pain disorder, presents a significant challenge in healthcare due to its widespread musculoskeletal pain, tenderness, and a spectrum of associated symptoms.
- Trial name
- NCT06460636
- Testing
- progressive muscle relaxation therapy, aquatic therapy
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Progressive Multiple Sclerosis
G-EO Gait Rehabilitation Training in Progressive Multiple Sclerosis
The logistic advantages and advanced training capabilities of the G-EO System, as well as the benefits reported in other populations, support this strategy as a potentially potent rehabilitation tool for restoring and maintaining…
- Trial name
- NCT03980145
- Testing
- G-EO System (Reha Technology AG: Olten, Switzerland), Conventional Physical Therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Interstitial Lung Disease
PRospective Evaluation of Interstitial Lung DIsease Progression With Quantitative CT
The interstitial lung diseases (ILD) are a heterogenous group of conditions with varying degrees of inflammation and scarring (fibrosis) of the lungs. ILD progression is unpredictable, making prognostication challenging.
- Trial name
- PREDICT-ILD (NCT05609201)
- Testing
- HRCT Thorax, Glycocheck Endothelial Glycocalyx Assessment, Blood biomarkers
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Urinary Tract Infection Complicated, Urinary Tract Infection (cUTI)
Clinical Utility of a PCR Compared to Culture and Sensitivity Testing for the Management of cUTI in Adults.
Complicated urinary tract infections (cUTIs) often lead to the overuse of empiric antibiotics, risking inappropriate treatment and contributing to antimicrobial resistance.
- Conditions
- Urinary Tract Infection Complicated, Urinary Tract Infection (cUTI), Urinary Tract Infection (Diagnosis)
- Trial name
- PCR (NCT06996301)
- Testing
- Treatment guided by the PCR results, Treatment guided by the C&S results
- Where
- 6 sites in United States
- Volunteers
- 773 people
- Sponsor
- Doc Lab Inc
COVID-19, SARS-CoV-2
Azithromycin for COVID-19 Treatment in Outpatients Nationwide
This individually randomized telemedicine-based trial aims to evaluate the efficacy of a single dose of azithromycin for prevention of progression of COVID-19 in patients with a recent positive SARS-CoV-2 test who are not…
- Trial name
- ACTION (NCT04332107)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- Thomas M. Lietman
Diabetes Mellitus, Type 2, Hypertension
The Effect of Progressive Resistance Exercise Training (PRET) on CVRF in Adults With ID.
Thanks to improved healthcare, the life expectancy of people with ID is increasing and is approaching that of the general population.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Hypercholesterolemia, Obesity
- Trial name
- PRET (NCT06579898)
- Testing
- Progressive resistance exercise training
- Where
- 3 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- Erasmus Medical Center
Sepsis, Sepsis Associated DIC
A Study to Learn About the Occurrence of Disseminated Intravascular Coagulation in People With Sepsis and Further Worsening of Sepsis
This is an exploratory study in which data from people with sepsis (a serious condition in which the body responds to an infection that damages vital organs) admitted to an Intensive care unit (ICU) who will receive treatment are…
- Trial name
- NCT06986798
- Testing
- Local standard medical care
- Where
- 31 sites in Austria, Belgium and 5 more
- Volunteers
- 150 people
- Sponsor
- Bayer
Moderate Aortic Valve Stenosis, Moderate Aortic Valve Regurgitation
Prospective Observational Cohort Study of Moderate Aortic Valve Disease
The objective of this research is to evaluate and predict the progression of moderate aortic stenosis and regurgitation from clinical characterization, biological, echocardiographic, and computed tomography (CT) et. al.
- Conditions
- Moderate Aortic Valve Stenosis, Moderate Aortic Valve Regurgitation, Aortic Valve Disease
- Trial name
- NCT06595992
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cancer
Phase II Study of SOM230 in Patients With Recurrent or Progressive Meningioma
This is a single-arm, phase II trial of SOM230 in patients with documented recurrent or progressive intracranial meningioma who have failed conventional therapy and are not candidates for complete surgical resection of their…
- Trial name
- NCT00813592
- Testing
- SOM230B
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Utah
Alzheimer Disease, Early Onset, Alzheimer Disease
Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks
This study attempts to identify two types of AD by using clinical and cognitive tasks and brain imaging. The subtypes of AD are separated into a "typical" group (memory loss) and a "variant" group (language, visuospatial, and…
- Conditions
- Alzheimer Disease, Early Onset, Alzheimer Disease, Alzheimer Disease, Late Onset, Dementia, Alzheimer Type
- Trial name
- EOAD-Subtype (NCT03153371)
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Chronic Kidney Diseases
Metformin as RenoProtector of Progressive Kidney Disease
A multi-center, practice-oriented, repurposing, double-blinded, placebo-controlled, randomized clinical trial. The RenoMet trial is repurposing an already approved agent (Metformin , Glucophage SR ) in a new indication…
- Trial name
- RenoMet (NCT03831464)
- Testing
- Metformin Hydrochloride
- Where
- 19 sites in Belgium
- Volunteers
- 290 people
- Sponsor
- Universiteit Antwerpen
Leukemia
Role of Biomarkers in Disease Progression in Samples From Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01500499
- Testing
- gene expression analysis, gene rearrangement analysis, polymerase chain reaction
- Volunteers
- 20 people
- Sponsor
- Children's Oncology Group
Puberty, Precocious, McCune-Albright Syndrome
Faslodex in McCune-Albright Syndrome
The purpose of this study is to evaluate the safety, effectiveness and pharmacokinetics of a study drug called Faslodex (fulvestrant) in the treatment of progressive precocious puberty (PPP) (early puberty) in girls with…
- Trial name
- FMAS (NCT00278915)
- Testing
- Fulvestrant
- Where
- 16 sites in United States, France and 4 more
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Progressive Multifocal Leucoencephalopathy (PML)
T-cell Therapy in Patients With PML
There is no approved standard treatment für progressive multifocal leukoencephalopathy (PML). The sponsor of the study is developing a new treatment.
- Trial name
- NCT06990087
- Testing
- Application of T-lymphocytes
- Where
- 7 sites in Germany
- Volunteers
- 23 people
- Sponsor
- Hannover Medical School
Pulmonary Disease, Chronic Obstructive, Adverse Effect of Glucocorticoids and Synthetic Analogues
Reduction of Corticosteroid Use in Outpatient Treatment of Exacerbated COPD
Background Chronic obstructive pulmonary disease (COPD) is a major public health issue with no curative treatment. In Switzerland estimated 5-7% of the total population are suffering from this chronic disease.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Adverse Effect of Glucocorticoids and Synthetic Analogues, Disease Exacerbation
- Trial name
- RECUT (NCT02386735)
- Testing
- Prednisone
- Where
- Switzerland
- Volunteers
- 133 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Metastatic Castration Resistant Prostate Cancer
A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation
The primary objective is to assess the activity and efficacy of pembrolizumab, a checkpoint inhibitor, in Veterans with metastatic castration-resistant prostate cancer (mCRPC) characterized by either mismatch repair deficiency…
- Trial name
- CHOMP (NCT04104893)
- Testing
- Pembrolizumab
- Where
- 13 sites in United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Knee
Comparison of Progressive Motor Imagery and Sensorimotor Exercises in Knee Osteoarthritis
Osteoarthritis is the most common type of arthritis, which can affect all joints in the body and includes synovial inflammation, cartilage degeneration, osteophyte formation and bone remodeling in its pathophysiology.
- Trial name
- NCT05850793
- Testing
- Sensorimotor Exercise, Conventional Exercise, Progressive Motor Imagery Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul Medipol University Hospital
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