Clinical trials: Probiotic Intervention
Constipation, Probiotic
Multi-strain Probiotic Effects on Self-Reported Constipation
Constipation is a prevalent gastrointestinal condition. Beyond simple lifestyle measures (e.g. increasing fibre intake, hydration, levels of exercise), medical therapies are available for management.
- Conditions
- Constipation, Probiotic, Probiotic Intervention
- Trial name
- NCT07275866
- Testing
- Multi-strain probiotics
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Dr Anthony Hobson
Probiotic Intervention, Healthy Adult Participants
Early Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults
This study is a pre-post, open-label pilot feasibility study designed to investigate how a food-grade probiotic supplement affects biological measurements and wellbeing in healthy adults.
- Trial name
- ePROFILE20 (NCT07841457)
- Testing
- Probiotic Supplement (1C-01)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- OneCarbon
Obesity (Disorder), GLP-1 Receptor Agonist Treatment
Probiotics in Obese Patients Treated With Semaglutide
This randomized, double-blind, placebo-controlled trial evaluated the effects of a four-strain probiotic formulation in adults with obesity receiving semaglutide.
- Conditions
- Obesity (Disorder), GLP-1 Receptor Agonist Treatment, Probiotic Intervention, Diabetes Mellitus Type 2
- Trial name
- ProSem (NCT07847593)
- Testing
- Four-strain probiotic formulation
- Where
- 3 sites in Poland
- Volunteers
- 102 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Colonization, Asymptomatic, Probiotic Intervention
Probiotic in Fruit Snack
The aim of this study is to investigate whether a fruit snack containing probiotic ''Lactobacillus rhamnosus'' can survive and establish itself more effectively in the gut when it is protected inside a natural plant-protein…
- Conditions
- Colonization, Asymptomatic, Probiotic Intervention, Gut Microbiota Diversity and Composition, Gut-brain Axis
- Trial name
- Probiotics (NCT07679490)
- Testing
- Microencapsulated Lactobacillus rhamnosus Fruit Snack
- Where
- Ireland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Major Depressive Disorder (MDD), Probiotic Intervention
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression
The goal of this clinical trial is to evaluate the efficacy and safety of sertraline combined with Lactobacillus crispatus in adolescents aged 12-18 years with major depressive disorder.
- Trial name
- NCT07539805
- Testing
- Sertraline combined with Lactobacillus crispatus
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Major Depressive Disorder (MDD), Probiotic Intervention
Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression
The objective of this clinical trial is to evaluate the efficacy and safety of sertraline combined with multi-strain probiotics in adolescents aged 12-18 with major depressive disorder.
- Trial name
- NCT07645157
- Testing
- Sertraline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Osteopenia, Osteoporosis
Food Trial Evaluating Fecal Abundance of SBD111 With Once-Daily Versus Twice-Daily Administration in Healthy Adults
The purpose of this study is to determine whether a modified formulation and daily intake schedule of SBD111 results in similar levels of probiotic microbes in the gut compared with the currently used formulation.
- Conditions
- Osteopenia, Osteoporosis, Menopause Related Conditions, Probiotic Intervention
- Trial name
- NCT07538167
- Testing
- SBD111(current formulation), SBD111 (new formulation)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Solarea Bio, Inc
Probiotic Intervention
Probiotic Research On Safety, Palatability, Efficacy and Receptivity
The goal of this pilot study is to determine if taking a commercially available probiotic product can influence levels of vitamins B12, B6 and folate after a 4-week supplementation period in reproductive-aged women without any…
- Trial name
- PROSPER (NCT07512557)
- Testing
- Probiotic Capsule
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Carleton University
Obesity, Homeostasis
Probiotic Intervention on Body Weight
This study is a randomized controlled trial with 120 overweight or obese (body-mass index, BMI, ≥ 24 kg/m²) participants and 20 normal-weight participants.
- Conditions
- Obesity, Homeostasis, Weight Loss, Probiotic Intervention
- Trial name
- NCT06989177
- Testing
- General lifestyle and nutritional education, Energy-restricted nutritional and lifestyle intervention, Probiotic
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
COPD (Chronic Obstructive Pulmonary Disease), Probiotic Intervention
Probiotics in Pulmonaty Rehabilitation for COPD
This study aims to investigate various aspects of patients with chronic respiratory diseases undergoing pulmonary rehabilitation supplemented with probiotics.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Probiotic Intervention, Body Composition Measurement
- Trial name
- NCT06717659
- Testing
- probiotic supplementation intervention, standard pulmonnary rehabilitation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University
Microecological Therapy, Probiotic Intervention
Effects of DL-endopeptidase Producing Probiotics on Human Intestinal NOD2 Ligands and Related Functions
We have discovered a type of probiotic that can target activating intestinal NOD2, which is related to a series of human health issues.
- Trial name
- probiotics (NCT06716047)
- Testing
- Oral administration
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Infective Endocarditis, Endocarditis, Bacterial
Combined Rehabilitation and Nutritional Support vs. Standard Care in In-Hospital Endocarditis Treatment
Infective endocarditis (IE) is associated with high morbidity and mortality. Patients with IE are affected by a lengthy hospitalization, leading to physical deconditioning and a rapid decline in physical fitness, muscle mass and…
- Conditions
- Infective Endocarditis, Endocarditis, Bacterial, Infection; Heart, Bacteremia
- Trial name
- ENDOCARE (NCT06563609)
- Testing
- Intensive physical Therapy, Probiotic treatment, Individualised Nutritional Support
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Johannes Grand
Cross Infection (Hospital-Acquired Infections), Critical Illness
Probiotics for Preventing ICU-Acquired Infections in Critically Ill Patients: A Pilot Study
This pilot randomized clinical trial investigated the effect of probiotic supplementation on the incidence of intensive care unit-acquired infections (ICU-AIs) in critically ill patients.
- Conditions
- Cross Infection (Hospital-Acquired Infections), Critical Illness, Probiotic Intervention
- Trial name
- NCT07144124
- Testing
- Biopro-max 8 Billion Probiotics (Bioserv Healthcare)
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Colitis, IBD (Inflammatory Bowel Disease)
Evaluate the Efficacy and Safety of Probiotic 6600 as an Adjuvant Therapy for Colitis
This study was conducted in two phases. In Phase I, 40 UC participants, 40 CD participants, and 40 colitis participants were randomly assigned in a 1:1 ratio to the experimental group and the control group, respectively.
- Conditions
- Colitis, IBD (Inflammatory Bowel Disease), Probiotic Intervention
- Trial name
- NCT07047339
- Testing
- Probiotics 6600
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Probiotic Intervention
Probiotic Intervention, Bile Acids and Lipid Metabolism Metabolic Profile in Healthy Overweight Subjects.
Moderate hypercholesterolemia, metabolic alterations derived from overweight or obesity, and consequently and their related cardiovascular risks can be reduced through changes in lifestyle.
- Trial name
- PROBILIP (NCT05378230)
- Testing
- Probiotic preparation of three Lactobacillus plantarum strains (CECT 7527, CECT 7528, CECT 7529)
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau