Clinical trials: Primary Hyperparathyroidism
Quality of Life in Primary Hyperparathyroidism
Parathyroid Assessment of Symptoms French Version
Primary hyperparathyroidism has been associated with an impaired quality of life. Surgery has been suggested to improve this outcome in patients with baseline quality of life impairment; however, few studies have used specific…
- Trial name
- PAS_fr (NCT06450431)
- Testing
- SF-36 questionnaire French version and PAS.fr questionnaire
- Where
- France
- Volunteers
- 548 people
- Sponsor
- Nantes University Hospital
Hyperparathyroidism
18F-fluorocholine PET/CT for Hyperparathyroidism
Hyperparathyroidism is a common endocrine disorder which can result in many severe complications. For patients with hyperparathyroidism, Tc-99m sestamibi imaging is the major imaging tool for pre-operative localization of the…
- Trial name
- NCT04316845
- Testing
- 18F-fluorocholine PET/CT
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Primary Hyperparathyroidism
Effect of Mechanical Loading on vBMD and Geometry in Patients With Primary Hyperparathyroidism
In this study we aimed to evaluate the effect of primary hyperparathyroidism (PHPT) on bone geometry simultaneously at the tibia and the radius, peripheral bone sites with similar structure but subject to different loading…
- Trial name
- NCT05426512
- Volunteers
- 120 people
- Sponsor
- EFSTATHIOS CHRONOPOULOS
Coronary Artery Disease, Proteus Syndrome
Informed Consent for Whole Genome Sequencing: Ideals and Norms Referenced by Early Participants
Since 2007, the cost of sequencing a diploid human genome has fallen dramatically, from approximately $70 million to $20,000. As affordable sequencing platforms become more widely available, the advancement of biomedical science…
- Conditions
- Coronary Artery Disease, Proteus Syndrome, Coffin - Sins Syndrome, Familial Isolated Hyperparathyroidism
- Trial name
- NCT01369953
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Primary Hyperparathyroidism, Hypercalcemia
Primary Hyperparathyroidism (PHPT): Early Effect of Vitamin D
Primary hyperparathyroidism (PHPT) is a common disease that occurs in 1 in 10,000 people every year. In the presence of this condition, the parathyroid glands produce excessive amounts of parathyroid hormone (PTH), which…
- Conditions
- Primary Hyperparathyroidism, Hypercalcemia, Vitamin D Deficiency, Osteoporosis
- Trial name
- NCT01329666
- Testing
- Vitamin D3
- Where
- United States
- Sponsor
- Columbia University
Total Thyroidectomy, Bilateral Neck Exploration for Primary Hyperparathyroidism
Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery
Reliable identification of parathyroid glands is critical to the success of thyroid and parathyroid surgery. In thyroid surgery, inadvertent injury to parathyroid glands may cause temporary or permanent hypoparathyroidism (low…
- Trial name
- NCT02089542
- Testing
- MB and fluorescent imaging
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Parathyroid Adenoma, Parathyroid Neoplasms
Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy
This study will see if the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during parathyroidectomy (PTx) procedures is better…
- Conditions
- Parathyroid Adenoma, Parathyroid Neoplasms, Parathyroid Cancer, Hypercalcemia
- Trial name
- NCT05022641
- Testing
- PTeye, Standard of Care
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Michigan
Primary Hyperparathyroidism (PHPT)
Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism
The present study is designed to examine the expression of VDR, CaSR, PTH, Cyclin D1, Ki67 and PCNA and to find out its relationship with clinical parameters in parathyroid adenomas.
- Trial name
- NCT01228786
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Primary Hyperparathyroidism, Primary Hyperparathyroidism Due to Adenoma
A Retrospective Analysis of the Diagnostic Performance of 11C-choline PET/CT in Primary Hyperparathyroidism
The leading cause of primary hyperparathyroidism (pHPT) is a solitary adenoma (89%). The treatment of pHPT is generally surgical removal of the overactive parathyroid gland(s).
- Trial name
- NCT04608253
- Testing
- 11C-choline PET/CT
- Volunteers
- 36 people
- Sponsor
- University Medical Center Groningen
Primary Hyperparathyroidism, Osteoporosis, Postmenopausal
Circulating miRNA in Primary Hyperparathyroidism
The goal of this study is to: 1. Analyze the expression levels of circulating (serum) miRNAs in primary hyperparathyroidism patients with and without osteoporosis, and patients with osteoporosis undergoing thyroidectomy, and to…
- Trial name
- NCT03931109
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Pennsylvania
Primary Hyperparathyroidism
Cohort Primary Hyperparathyroidism
CoHPT is a prospective, monocentric, observational cohort including all patients diagnosed with primary hyperparathyroidism in Nantes University Hospital, aiming to study the outcomes associated with parathyroidectomy.
- Trial name
- CoHPT (NCT05469087)
- Where
- France
- Volunteers
- 403 people
- Sponsor
- Nantes University Hospital
Primary Hyperparathyroidism, Parathyroid Cancer
Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors
Background: People have 4 parathyroid glands near the thyroid gland in the neck. Surgery is needed to remove a parathyroid gland that is too large or has a tumor.
- Conditions
- Primary Hyperparathyroidism, Parathyroid Cancer, Multiple Endocrine Neoplasias, Heritable Hyperparathyroidism
- Trial name
- NCT07444723
- Testing
- 18F-FCH, NeuroEXPLORER
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Primary Hyperparathyroidism
11C Methionine PET for the Detection of Hyperfunctional Parathyroid Tissues
The overall sensitivity and specificity of 11C-MET PET/CT is superior to 18F-FDG PET/CT and conventional SPECT-CT for the detection of abnormal parathyroid glands.
- Trial name
- NCT01783002
- Testing
- 11C-Methionine PET/CT scanning, 18F-FDG PET/CT scanning, SPECT-CT scanning
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Heart Failure, Atrial Fibrillation (AF)
Cardiovascular Risk in Patients With Primary Hyperparathyroidism
Patients with primary hyperparathyroidism versus healthy controls assessed for their cardiovascular risk and overt CVD
- Conditions
- Heart Failure, Atrial Fibrillation (AF), Arrhythmia, Coronary Artery Disease
- Trial name
- CVD-PHPT (NCT07870369)
- Where
- Bulgaria
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Medical University of Sofia
Primary Hyperparathyroidism
Preliminary Study Concerning the Validity of Parathyroid Exploration on a CZT Camera
The goal of this study is to assess the performance of parathyroid imaging on a cardiac-dedicated CZT camera, compared to planar pinhole imaging, in patients referred for primary hyperparathyroidism.
- Trial name
- PARAT-CZT (NCT02854345)
- Testing
- Tomoscintigraphic parathyroid imaging on a CZT camera
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Primary Hyperparathyroidism
EC17 for Intraoperative Imaging for Parathyroidectomy
Primary hyperparathyroidism is a significant medical and public health problem in the world and affects approximately 100,000 new patients in the United States alone.
- Trial name
- NCT01996072
- Testing
- EC17
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Primary Hyperparathyroidism Due to Adenoma
Intraoperative Identification of Parathyroid Adenomas Using PTeye™ and FLUOBEAM® LX: a Prospective Cohort Study
The goal of this observational study is to evaluate the efficacy of PTeyeTM device to confirm a parathyroid adenoma on a visually suspected tissue in comparison with the FLUOBEAM®LX device.
- Trial name
- PTeye (NCT06788223)
- Testing
- Parathyroidectomy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Hyperparathyroidism, Primary
Autofluorescence in Surgery for Primary Hyperparathyroidism
The study aims to test if autofluorescence imaging (AF) is a useful surgical aid during parathyroidectomy (PTX) for primary hyperthyroidism (PHPT).
- Trial name
- NCT06230380
- Testing
- Surgery with autofluorescence
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Primary Hyperparathyroidism
The Crosstalk Between Calcium-sensing Receptor Signaling and Endocannabinoid System in Primary Hyperparathyroidism
Despite the strong association of hyperparathyroidism with arachidonic acid related lipid signals, little research has been performed over the years.
- Trial name
- Targeting CaSR (NCT03831620)
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parathyroid Cancer, Primary Hyperparathyroidism
Natural History Study of Parathyroid Disorders
Background: Parathyroid disorders are very common in the general population and include disorders of parathyroid excess, deficiency, or defects in parathyroid hormone (PTH) signaling.
- Conditions
- Parathyroid Cancer, Primary Hyperparathyroidism, Pseudohypoparathyroidism, Inheritable Bone Diseases
- Trial name
- NCT04969926
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)