Clinical trials: Primary Hyperaldosteronism
Primary Hyperaldosteronism
Parent Study: A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism Sub-study: A Follow-up Substudy After Completion of the BaxPA Main Study.
Parent study: This is a Phase III, multicentre, randomised, double-blind, placebo-controlled, parallel-group study to evaluate the safety, tolerability, and efficacy of baxdrostat versus placebo, on the reduction of Seated Blood…
- Trial name
- BaxPA (NCT07007793)
- Testing
- Baxdrostat
- Where
- 76 sites in United States, Australia and 10 more
- Volunteers
- 212 people
- Sponsor
- AstraZeneca
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism
In this study, the investigators will perform endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) treatment of left-sided adrenal tumours in patients with primary aldosteronism (PA) and in patients with mild autonomous…
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Hypercortisolism
- Trial name
- NCT05368090
- Testing
- EUS-RFA of left adrenal tumour in PA with AVS-verified left lateralisation, EUS-RFA of left adrenal tumour in PA, "debulking group", EUS-RFA of left adrenal tumour in MACS with AVS-verified left lateralisation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Hypertension, Primary Aldosteronism
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy.
- Conditions
- Hypertension, Primary Aldosteronism, Hypokalemia
- Trial name
- SSTT (NCT06569589)
- Testing
- 23NaMRI Scan, Potassium Chloride (KCl)
- Where
- 4 sites in Singapore
- Volunteers
- 80 people
- Sponsor
- Jens Titze
Primary Aldosteronism
Finerenone for Patients With Primary Aldosteronism (FAIRY)
Using spironolactone as the control, to assess the efficacy and safety of finerenone in patients with primary aldosteronism(PA).
- Trial name
- NCT06457074
- Testing
- Finerenone Oral Tablet, Spironolactone Oral Tablet
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Chongqing Medical University
Aldosterone Disorder, Adrenal Gland Disease
Prospective Phenotyping of Autonomous Aldosterone Secretion
This prospective cohort study will investigate the physiology and progression of autonomous aldosterone secretion.
- Conditions
- Aldosterone Disorder, Adrenal Gland Disease, Blood Pressure
- Trial name
- NCT03484130
- Testing
- Sodium loaded diet, Restricted sodium diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Primary Aldosteronism
A Phase II Clinical Study on the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism
This study is a multicenter, randomized, double-blind, placebo-parallel-controlled phase II clinical trial to evaluate the efficacy and safety of HRS-1780 compared with placebo in participants with primary aldosteronism.
- Trial name
- NCT07470983
- Testing
- HRS-1780 Tablets
- Where
- 2 sites in China
- Volunteers
- 61 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Primary Aldosteronism
The Effect of SAAE on Ventricular Remodeling in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.
- Trial name
- NCT05501080
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Primary Aldosteronism
Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Method
To compare the consistency of 24-hour urinary aldosterone in the diagnosis of primary aldosteronism by oral sodium loading test between the second day method and the third day method
- Trial name
- NCT06750172
- Testing
- The oral sodium loading test
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Primary Aldosteronism and Surgically Curable Forms in Hypertension Patients Using 11C-Metomidate
10% of patients with hypertension potentially have the treatable condition - primary aldosteronism. Primary aldosteronism (PA) is caused by either bilateral adrenal disease (~40%), managed with lifelong medications; or unilateral…
- Trial name
- NCT03990701
- Testing
- 11C-Metomidate PET/CT Scan
- Where
- Singapore
- Volunteers
- 25 people
- Sponsor
- Changi General Hospital
Primary Aldosteronism, Super Selective Adrenal Arterial Embolization
Super Selective Adrenal Artery Embolization for Primary Aldosteronism: a Prospective Cohort Study(SAAE-PA)
The objective of this study was to evaluate the efficacy and safety of adrenal vein blood extraction for primary aldosteronism classification and adrenal artery embolization in the treatment of primary aldosteronism, to provide…
- Trial name
- NCT06513676
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xinjiang Medical University
Resistant Hypertension, Primary Aldosteronism
Prospective Study on Primary Aldosteronism in Resistant Hypertension
Prevalence of primary aldosteronism (PA) in resistant hypertension is not clear. In addition, emerging evidence supports the role of elevated serum aldosterone in promoting cardiovascular disease, independently from high blood…
- Conditions
- Resistant Hypertension, Primary Aldosteronism, Refractory Hypertension, Hypertensive End-Organ Damage
- Trial name
- PrePARe (NCT04213963)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Turin, Italy
Primary Aldosteronism, Secondary Hypertension
PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism
This study is a randomized controlled trial to assess the clinical utility of gallium-68 pentixafor PET/CT in the management of primary aldosteronism (PA).
- Conditions
- Primary Aldosteronism, Secondary Hypertension, Aldosterone-Producing Adenoma, Idiopathic Hyperaldosteronism
- Trial name
- NCT07027254
- Testing
- 68Ga-pentixafor PET/CT
- Where
- 2 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Primary Aldosteronism
Renal Cysts and Primary Aldosteronism
During routine subtyping of confirmed primary aldosteronism by adrenal vein sampling extra plasma samples are drawn from both renal veins and from inferior vena cava.
- Trial name
- NCT05435703
- Where
- Finland
- Volunteers
- 115 people
- Sponsor
- Tampere University Hospital
Primary Aldosteronism
Comparing Inclisiran Versus Statin for Primary Aldosteronism
Primary aldosteronism represents one of the leading causes of resistant hypertension. Circulating cholesterol is established as the exclusive substrate for adrenal aldosterone synthesis, and statins, which suppress cholesterol…
- Trial name
- NCT07884955
- Testing
- inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism, Essential Hypertension
The Plasma Metabolomics Profiling of Primary Aldosteronism
Primary aldosteronism (PA), characterized by overt renin-independent aldosterone production, is the most common form endocrine hypertension.
- Conditions
- Primary Aldosteronism, Essential Hypertension, Idiopathic Aldosteronism, Aldosterone-producing Adenoma
- Trial name
- NCT06500000
- Testing
- liquid chromatography-mass spectrometry (LC/MS)
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Third Military Medical University
Primary Aldosteronism
Short- and Long-term Outcomes of Adrenalectomy for Primary Aldosteronism
The proposed study is this. Short- and long-term outcomes of adrenalectomy for Primary Aldosteronism (PA) in a single centre. PA is a relatively common problem and considers as the commonest cause of secondary hypertension and…
- Trial name
- NCT06192810
- Testing
- Laparoscopic/open adrenalectomy
- Volunteers
- 84 people
- Sponsor
- University College London Hospitals
Primary Aldosteronism, Hypertension
Effects of Adrenal Artery Ablation and Spironolactone in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is one of the most common cause of endocrine and resistant hypertension. Current studies have shown that the activation of the renin-angiotensin-aldosterone system (RAAS) and the increased sympathetic…
- Trial name
- NCT04409431
- Testing
- Endovascular chemical Ablation of Adrenal Gland
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Military Medical University
Hyperaldosteronism Primary
Is the Evolution of the Aldosterone-renin Ratio Pre- Versus Post-operative on Day 1 Following Unilateral Adrenalectomy for Primary Hyperaldosteronism Predictive of Blood Pressure Outcomes
Primary hyperaldosteronism is characterised by excessive and autonomous aldosterone secretion by the adrenal glands, independent of renin.
- Trial name
- vRAR (NCT07110155)
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Non Invasive Imaging Methods for Detecting PA：a Clinical PET Study of 18F-Pentixather
Primary aldosteronism (PA) is the most common endocrine cause of hypertension. 68Ga-pentixafor PET/CT possesses a relatively high sensitivity and specificity for Aldosterone producing adenoma (APA) detection.
- Trial name
- NCT06581744
- Testing
- [18F]AlF-NOTA-Pentixather
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fangfang Sun
Primary Aldosteronism
The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is a disorder of the adrenal gland causing an autonomous overproduction of mineralocorticoids, leading to arterial hypertension. Although rare, it is the most frequent cause of secondary hypertension.
- Trial name
- NCT02216721
- Where
- Malaysia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak