Clinical trials: Preterm Premature Rupture of the Membranes
Pregnancy, Previous Cesarian Section
Management of Labor in Patients With Previous Cesarian Section
Induction of labor in women desiring TOLAC has long been a topic of controversy. The paucity of published data on mechanical cervical ripening in the setting of TOLAC and term PROM has led us to undertake the present clinical…
- Conditions
- Pregnancy, Previous Cesarian Section, Premature Rupture of Membranes (PROM)
- Trial name
- NCT02196103
- Testing
- Double balloon cervical catheter
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Preterm Prelabor Rupture of Membranes, PPROM
Extended Azithromycin Treatment in Prelabor Rupture of Membranes
The purpose of this study is to learn whether adding extra doses of azithromycin to the standard antibiotic treatment for preterm prelabor rupture of membranes may improve pregnancy outcomes for patients between 22 weeks and 28…
- Trial name
- NCT07669207
- Testing
- Azithromycin (Azithro), Standard Azithromycin Dosing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alexa Henderson
Preterm Premature Rupture of Membranes
Magnesium Sulfate Versus Placebo for Tocolysis in PPROM
Study compares the outcomes of women between 26 and 32 wks gestation with rupture of membranes. Women randomized to receive tocolysis with magnesium sulfate x 48 hrs or placebo of saline IV x 48 hrs.
- Trial name
- NCT00463736
- Testing
- Magnesium sulfate
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Regional Obstetrical Consultants
Preterm Premature Rupture of Membranes
Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM)
The purpose of this study is to determine if the short term use of indomethacin will reduce the number of women delivering within 48 hours when given to women with preterm premature rupture of membranes (PPROM) between 24- 32…
- Trial name
- NCT00466128
- Testing
- indomethacin
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Chorioamnionitis
Intrapartum Study of Sterile and Clean Gloves
The purpose of this study is to determine whether the use of sterile or clean gloves during labor exams affects the rate of chorioamnionitis. Chorioamnionitis is an infection of the membranes around the baby.
- Trial name
- NCT01852188
- Testing
- Type of glove used for intrapartum vaginal exams
- Where
- United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Fetal Membranes, Premature Rupture, Preterm Birth Complication
Emotional Support for Women Experiencing PPROM
Preterm Prelabour Rupture of the Membranes is a pregnancy complication affecting 3% of all pregnancies. Outcomes for both the mother and baby are variable including: preterm delivery, fetal infection, cord prolapse, abruption as…
- Trial name
- NCT06262308
- Testing
- Psychological intervention along Cognitive Behavioural Therapy principles
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- King's College London
Premature Rupture of Fetal Membranes
Monitoring of the Inflammatory Response of Patients With Premature Rupture of Membranes With Bedside Tests
Prematurity represents 8% of birth and it is one of the leading causes of infant complications. The preterm premature rupture of membranes (PPROM) represents one-third of preterm birth and the rupture of membranes increase the…
- Trial name
- EFFARM (NCT00940043)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Sherbrooke
PPROM
Digital vs. Speculum Exams for PPROM
After preterm prelabor rupture of membranes (PPROM)[breaking of the amniotic sac prior to 37 weeks gestation in pregnancy], patients are recommended for inpatient admission and close monitoring for complications including preterm…
- Trial name
- MOCA (NCT05773014)
- Testing
- Speculum Exams, Digital Exams
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Preterm Labor, Preterm Premature Rupture of Membrane (PPROM)
Development of Pharmacokinetics Model in Pregnancy Women and Fetus
Pharmacokinetics analysis and development of pharmacokinetics model in pregnancy women and fetus
- Trial name
- NCT01916330
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Seoul National University Hospital
Preterm Premature Rupture of Membrane
Bed Rest After Preterm Premature Rupture of the Membranes
Antepartum bed rest is widely prescribed after preterm premature rupture of the membranes (PPROM), although its effectiveness to prevent preterm birth has not been demonstrated.
- Trial name
- NCT03814278
- Testing
- complete bed rest, activity restriction
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Lisboa Norte
Preterm Premature Rupture of Membranes, Pregnant State
Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes
In this study the investigators sought to determine the effects of Pomegranate (Natural pomegranate polyphenol (P. granatum L) extract) : 1. On the maternal and fetal oxidative stress and inflammation associated with PPROM. 2.
- Trial name
- NCT01584323
- Testing
- Pomgranate pills
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Music Therapy, Preterm Premature Rupture of Membrane (PPROM)
Physiological and Psychological Effects of Music Therapy in the Pregnant Woman and Fetus
To evaluate the effects of music therapy in the care of antepartum mothers admitted for long-term hospitalization due to the high-risk status of their pregnancy.
- Trial name
- WOMB (NCT05893485)
- Testing
- Music Therapy Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Christina Chianis Reed
Premature Rupture of Membrane
Preterm Premature Rupture of Fetal Membranes: Cervical Ultrasound and Biological Markers to Diagnose Prematurity (RECHOBIOL)
Our main hypothesis is to consider that the detection of biomarkers on admission combined with the length of the cervix would improve the prediction of the latency period in case of preterm premature rupture of membranes (pPROM).
- Trial name
- RECHOBIOL (NCT04237142)
- Testing
- Vaginal secretions collection, Blood sample
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pregnancy, Prematurity
Vaginal Probiotics During Pregnancy After Premature (24-32 Weeks of Gestation) Preterm Rupture of Membranes
The goal of this clinical trial is to evaluate the feasibility of the randomized controlled trial (RCT). Secondary objectives include comparing the microbiota of preterm babies born after premature rupture of membranes across…
- Conditions
- Pregnancy, Prematurity, PPROM
- Trial name
- PROB-PROM (NCT06965049)
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion
Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury Biomarkers
The AMNIO-BRAIN Trial is a research study looking at whether a simple treatment during labor can help protect a baby's brain. Some newborns develop a condition called hypoxic-ischemic encephalopathy (HIE), which happens when the…
- Conditions
- Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion, Neonatal Brain Injury
- Trial name
- AMNIO-BRAIN (NCT07610642)
- Testing
- Intrauterine Pressure Catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
Premature Birth
Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes
This trial hopes to prospectively evaluate the impact of one versus two courses of antenatal steroids on the incidence of major neonatal morbidity in pregnant women with pre-labor premature rupture of the membranes.
- Trial name
- ACSinPROM (NCT02469519)
- Testing
- Betamethasone - ACTIVE
- Where
- 9 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Pediatrix
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Preterm Premature Rupture of Membrane
mtDNA as Novel Biomarker for Intra-amniotic Infection
Finding a predictive biomarker for IAI could improve the clinical outcome for the mother and the neonate. The aim of this study is to quantify the copy number of circulating cell-free mitochondrial DNA in maternal serum and the…
- Trial name
- mtDNA (NCT03306719)
- Testing
- Blood sampling
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Preterm Premature Rupture of Membranes (PPROM), Premature Rupture of Membranes (PROM)
Effects of Emotional Freedom Technique and Music Therapy in High-Risk Pregnancy
Pregnancy is a physiological process; however, it is also a dynamic period during which obstetric and medical complications that may threaten maternal and fetal health can occur.
- Conditions
- Preterm Premature Rupture of Membranes (PPROM), Premature Rupture of Membranes (PROM), High-Risk Pregnancy
- Trial name
- NCT07559071
- Testing
- Emotional Freedom Technique (EFT), Music Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 177 people
- Sponsor
- Selcuk University
Oligohydramnios
Amnioinfusion Initiative
The aim of this study is to compare perinatal survival in patients presenting with early spontaneous PPROM and persistent oligohydramnios, managed either conservatively or with serial amnioinfusions.
- Trial name
- NCT00787163
- Testing
- amnioinfusion
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Università degli Studi di Brescia