Clinical trials: Preoperative Patients
Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult
Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma
The purpose of the study is to investigate whether a personalized selection of patients with localized soft tissue sarcoma for preoperative proton radiation therapy can reduce long-term radiation side effects without increasing…
- Conditions
- Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult, Soft Tissue Sarcoma of the Trunk and Extremities, Synovial Sarcomas
- Trial name
- PROSARC-1 (NCT07169344)
- Testing
- preoperative, Quality of life, Functional outcome
- Where
- 4 sites in Norway
- Volunteers
- 110 people
- Sponsor
- Oslo University Hospital
Carcinoma, Non Small Cell Lung
Gemcitabine/Platinum Containing Regimens as Preoperative Chemotherapy for Patients With Non Small Cell Lung Cancer
To study the efficacy and tolerability of gemcitabine/platinum chemotherapy in non small cell lung cancer
- Trial name
- NCT00191230
- Testing
- gemcitabine, carboplatin, cisplatin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Eli Lilly and Company
Non-small Cell Lung Carcinoma
Evaluation of FLT-PET and DWI-MRI in Patients With NSCLC Treated With a Platinum-based Doublet as Preoperative Chemo
The purpose of the study is to qualify, independently, tumor cell proliferation by 3'-Deoxy-3'-[18F]Fluorothymidine (FLT) -Positron Emission Tomography , and cell death by Diffusion Weighted Imaging (DWI) -Magnetic Resonance…
- Trial name
- EVIDENCE (NCT02273271)
- Testing
- 18F-FLT-PET/CT and DWI-MRI
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 31 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Glioblastoma Multiforme, Meningioma
Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients
In the proposed trial, patients will be administered ribociclib prior to surgical resection of their tumor. Patients will be enrolled in time-intervals sequentially (non-randomized).
- Trial name
- NCT02933736
- Testing
- Ribociclib
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Nader Sanai
PDAC - Pancreatic Ductal Adenocarcinoma
Forecasting Occult liveR Metastasis Using an Exosomal Signature for Intelligent Guided Hepatic Targeting
Early liver metastasis (Early-LiM) is the most significant prognostic factor in pancreatic ductal adenocarcinoma (PDAC) and is thought to originate from occult micrometastases present at the time of surgery.
- Trial name
- FORESIGHT (NCT07224802)
- Testing
- EXELiM assay (qRT-PCR validation), EXELiM small RNA sequencing
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- City of Hope Medical Center
Arthroplasty
Preoperative Pain, Function, and Activity for Total Hip and Knee Arthroplasty Patients
This study wish to show if the preoperative level of pain, function or activity for hip and knee arthroplasty patients has any predictive value of the time it takes to fulfill the well-defined discharge criteria.
- Trial name
- NCT01248039
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Hvidovre University Hospital
Dyspnea After Interscalene Nerve Block
Preoperative Maximum Inspiratory Pressure and Outcomes After Interscalene Block in Obese Patients
The study aims to explore if Maximum Inspiratory Pressure can predict postoperative breathlessness in obese patients receiving interscalene blocks for shoulder surgery.
- Trial name
- NCT06549244
- Testing
- Maximum Inspiratory Pressure monitoring
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of North Carolina, Chapel Hill
Breast Cancer, Mastectomy
Music Intervention for Preoperative Anxiety and Acute Pain Among Mastectomy Patients
Anxiety is a common thing that patients experience when they are preparing to have a surgery. When this anxiety is not properly treated, the patients tend to consume more drugs in the operating room and it also cause their pain…
- Conditions
- Breast Cancer, Mastectomy, Pain, Postoperative
- Trial name
- NCT04824183
- Testing
- Music intervention
- Where
- 3 sites in Malawi, Nigeria
- Volunteers
- 36 people
- Sponsor
- Chinese University of Hong Kong
Gynecologic Cancer, Anemia
Ferric Derisomaltose and Outcomes in the Recovery of Gynecologic Oncology: ERAS (Enhanced Recovery After Surgery)
Iron deficiency has been reported in approximately 35% of patients with a gynecologic malignancy. Blood transfusions are known to be immunosuppressive and carry immediate and long-term risks.
- Conditions
- Gynecologic Cancer, Anemia, Iron-deficiency
- Trial name
- FORGE II (NCT05407987)
- Testing
- Ferric derisomaltose
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- AHS Cancer Control Alberta
Breast Cancer
Monitoring and Predicting Chemotherapy Response Using DOSI
RATIONALE: New imaging procedures, such as diffuse optical spectroscopy imaging, may help measure a patient's response and allow doctors to plan better treatment.
- Trial name
- ACRIN6691 (NCT01217385)
- Testing
- DOSI
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- American College of Radiology Imaging Network
Glioblastoma
Multicentre Validation of How Vascular Biomarkers From Tumor Can Predict the Survival of the Patient With Glioblastoma
Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The relationship between non-invasive Magnetic Resonance Imaging (MRI) biomarkers at preoperative, postradiotherapy…
- Trial name
- ONCOhabitats (NCT03439332)
- Where
- Spain
- Volunteers
- 305 people
- Sponsor
- Juan M Garcia-Gomez
Colorectal Cancer, Liver Metastases
Preoperative Irinotecan Drug-eluting Beads for Patients With Unresectable Colorectal Liver Metastasis
Trans arterial chemoembolization using Irinotecan Drug-eluting Beads before liver surgery for patients with primarily unresectable colorectal liver metastasis
- Trial name
- NCT04912258
- Testing
- Trans arterial chemoembolization with Irinotecan Drug-eluting Beads
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Adrenal Insufficiency
The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid Surgery
Many drugs are used to prevent nausea and vomiting and pain after surgery. In this study the investigators will be looking at a drug, dexamethasone, which is commonly used to prevent nausea and vomiting and pain after surgery but…
- Trial name
- NCT01045876
- Testing
- Dexamethasone
- Where
- Canada
- Sponsor
- St. Paul's Hospital, Canada
Vulvar Cancer
Groin Sentinel Node Biopsy and 18FDG-PET/CT in cN0 Vulvar Cancer Patients Candidate to Standard Lymphadenectomy
The study aim is to verify the accuracy of SNB combined with 18F-FDG PET/CT in cN0 invasive vulvar cancer (IVC) patients currently not candidate to SNB according to standard guidelines.
- Trial name
- GroSNaPET (NCT02969278)
- Testing
- 18FDG-PET/TC, Sentinel node biopsy
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Catholic University of the Sacred Heart
Patient Satisfaction, Surgery
Preoperative Patient Education Via Animated Videos to Improve Patient Satisfaction and Reduce Complications in Head and Neck Surgery
This randomized control trial will compare traditional patient education methods (pamphlets, clinical visits) to the implementation of an innovated patient education platform.
- Trial name
- NCT04048538
- Testing
- Precare, usual standard of care
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Colorectal Cancer
Chemotherapy and Radiation Therapy Before Surgery Followed by Capecitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PETACC-6 (NCT00766155)
- Testing
- capecitabine, oxaliplatin
- Volunteers
- 1,094 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Esophageal Squamous Cell Carcinoma
Candonilimab (AK104) Plus Preoperative Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma (ESCC)
This is a prospective, single-arm, open-label，multi-center, phase II study, aiming to evaluate the efficacy and safety of AK104 combined with preoperative chemotherapy in patients with locally advanced ESCC.
- Trial name
- NCT05896787
- Testing
- AK104, nab-paclitaxel, carboplatin
- Where
- 2 sites in China
- Volunteers
- 45 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Pancreatoduodenectomy, PPPD
Duration of Perioperative Antibiotics in Pancreatoduodenectomy
The goal of this clinical trial is to compare two perioperative antibiotic prophylaxis regimens in adult patients undergoing pancreatoduodenectomy (PD) or pylorus-preserving pancreatoduodenectomy (PPPD).
- Conditions
- Pancreatoduodenectomy, PPPD, Infectious Complications
- Trial name
- NCT07043855
- Testing
- single dose preoperative antibiotic, Prolonged perioperative antibiotics
- Where
- South Korea
- Volunteers
- 558 people
- Sponsor
- Asan Medical Center
Cesarean Section, Surgical Site Infection
Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor
Surgical site infections (SSI) are the second most common cause of nosocomial infections accounting for 15% of all nosocomial infections among hospitalized patients and 38% of nosocomial infections in surgical patients.
- Conditions
- Cesarean Section, Surgical Site Infection, Nosocomial Infection
- Trial name
- PRACTICAL (NCT03423147)
- Testing
- 2% chlorhexidine gluconate cloth, 4% Chlorhexidine gluconate vaginal scrub
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Angela Bianco
Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8
Apalutamide and Gonadotropin-Releasing Hormone Analog With or Without Abiraterone Acetate in Treating Participants With Prostate Cancer
This phase II trial studies how well apalutamide and gonadotropin-releasing hormone analog with or without abiraterone acetate work in treating participants with prostate cancer prior to surgery.
- Conditions
- Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8, Stage IIC Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8
- Trial name
- NCT03279250
- Testing
- Abiraterone Acetate, Apalutamide, Gonadotropin-releasing Hormone Analog
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- M.D. Anderson Cancer Center
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