Clinical trials: Pregnancy Trimester, First, open to volunteers
Retained Products of Conception, Hysteroscopy
Predictors of Successful Office Operative Hysteroscopy Using a Mini-Resectoscope
The goal of this observational study is to identify predictors of successful removal of benign intrauterine pathology using a mini-resectoscope during office operative hysteroscopy without anesthesia in adult women with suspected…
- Conditions
- Retained Products of Conception, Hysteroscopy, Endometrial Polyp Benign, Endometrial Polyp
- Trial name
- NCT07875985
- Testing
- Office Operative Hysteroscopy Using the Karl Storz Mini-Resectoscope Without Anesthesia
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Preeclampsia
Molecular Study of the Maternal-fetal Interface in Preeclampsia.
Preeclampsia (PE) is a major obstetric complication with short- and long-term consequences for the mother and the fetus. Early screening tools to reduce its mortality and morbidity, as well as to prevent the life-threatening…
- Trial name
- PREMAFE (NCT06232668)
- Testing
- Maternal-fetal interface biopsy and peripheral blood collection in cases group, Maternal-fetal interface biopsy and peripheral blood collection in control group
- Where
- 4 sites in Spain
- Volunteers
- 2,084 people
- Sponsor
- Carlos Simon Foundation
Preeclampsia (PE), Fetal Growth Restriction
The Combined First Trimester Screening
The project is a national, prospective, multicenter pilot project. The project is focus on setting up the combined first trimester screening in the Czech Republic.
- Conditions
- Preeclampsia (PE), Fetal Growth Restriction, Congenital Abnormalities, Preterm Labor
- Trial name
- NCT07015203
- Where
- 3 sites in Czechia
- Volunteers
- 2,000 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Gestational Diabetes Mellitus in Pregnancy
First Trimester Prediction of Gestational Diabetes Mellitus by Continuous Glucose Monitoring.
Gestational diabetes mellitus (GDM) is the most common complication of pregnancy, with an incidence rate of 10-15% [1]. Common risk factors for GDM are increased maternal age and weight and as a consequence of women delaying…
- Trial name
- GLUCO-GCM (NCT06874907)
- Testing
- Glucose monitoring
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Neural Tube Defects (NTDs)
First-Trimester Screening of Open Neural Tube Defects Using Biometrics and Maternal Serum Markers
Open neural tube defects are congenital malformations associated with significant morbidity. Early detection during the first trimester remains a key challenge.
- Trial name
- BIMAS (NCT07864142)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Iron Deficiency (Without Anemia), Reference Values
Iron Status of Non-anemic Pregnant Women in First Trimester
This cross-sectional study aims to establish reference intervals for iron biomarkers-including serum iron, ferritin, total iron-binding capacity (TIBC), and transferrin saturation (TSAT)-in healthy pregnant women during the first…
- Conditions
- Iron Deficiency (Without Anemia), Reference Values, Iron Deficiency Without Anemia
- Trial name
- NCT06990373
- Where
- Vietnam
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hung Vuong Hospital
Cervical Preparation
Mifepristone vs Misoprostol
The Investigator team hypothesizes that in a randomized trial comparing mifepristone-alone or misoprostol-alone for cervical preparation for procedural abortions at 12 to 16 weeks in hospital-based care, the proportion of…
- Trial name
- NCT06502158
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Abortion, First Trimester, Pain Management
Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion
The goal of this clinical trial is to learn whether use of a virtual reality (VR) headset showing a meditative nature video will help reduce pain and anxiety during a first trimester procedural abortion.
- Conditions
- Abortion, First Trimester, Pain Management, Pain After Surgery, Satisfaction
- Trial name
- CALM-VR (NCT07288047)
- Testing
- VR headset, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Study Investigator
Preeclampsia
Optimizing the Use of Aspirin for the Prevention of Preeclampsia
Pregnant women at higher risk for preeclampsia (PE) are currently recommended to take low-dose aspirin (acetylsalicylic acid, ASA) daily from the first trimester until 36 weeks of gestation.
- Trial name
- Optim-PRE (NCT07665853)
- Testing
- Discontinuation of Acetylsalicilic acid 150 mg/day at 24-28 weeks of gestation
- Where
- 38 sites in Austria, Bulgaria and 5 more
- Volunteers
- 15,160 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Abortion in First Trimester
The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy
Medical termination of pregnancy (mTOP) generally involves using either a combined regimen consisting of mifepristone and misoprostol, or a misoprostol-only regimen.
- Trial name
- NCT05341817
- Testing
- Letrozole, Mifepristone
- Where
- Singapore
- Volunteers
- 144 people
- Sponsor
- KK Women's and Children's Hospital
Pregnancy Related
Longitudinal Study of Gene Expression in the Human Placenta During First-trimester and Full-term Pregnancy at the Single Cell Level
The single nucleus RNA-seq approach allows the placental transcriptome to be analyzed from nuclei, thus preserving the integrity of placental syncytium.
- Trial name
- VilliRNAseq (NCT06427408)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Iron Deficiency Anemia
Preconception vs First-Trimester Screening and Treatment for Iron Deficiency Anemia
This cluster randomized trial compares preconception with early-pregnancy anemia screening and iron supplementation, assessing late pregnancy iron deficiency anemia and maternal and infant outcomes.
- Trial name
- NCT07811765
- Testing
- Preconception Anemia Screening and Treatment Strategy, Early-Pregnancy Anemia Screening and Treatment Strategy
- Where
- China
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Miscarriage, Pregnancy Loss
Cost-utility Analysis of Outpatient Manual Vacuum Aspiration Versus Operating Room Electric Aspiration for the Management of First-trimester Miscarriage
The ASPIR study aims to evaluate the cost-utility of outpatient manual vacuum aspiration compared with operating room electric aspiration for the management of first-trimester miscarriage.
- Conditions
- Miscarriage, Pregnancy Loss, First Trimester Pregnancy
- Trial name
- ASPIR (NCT07732231)
- Testing
- Manual vacuum aspiration (MVA), Electric aspiration (EA)
- Where
- France
- Volunteers
- 860 people
- Sponsor
- Nantes University Hospital
Silent Miscarriage
Letrozole Versus Mifepristone and Misoprostol in Silent Miscarriage
Management of first trimester silent miscarriage can be by expectant, medical or surgical management. Surgical management by suction evacuation is associated with surgical risks (including risks to the womb that can affect…
- Trial name
- NCT06733727
- Testing
- Letrozole, Mifepristone
- Volunteers
- 884 people
- Sponsor
- The University of Hong Kong
Type 1 Diabetes, Preeclampsia
Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and Cardiovascular Risk in Women With Type 1 Diabetes
This multicenter observational cohort study aims to evaluate whether estimated first-trimester risk of preeclampsia (PE) is associated with subclinical atherosclerosis, cardiovascular risk profile, and cardiovascular events in…
- Conditions
- Type 1 Diabetes, Preeclampsia, Preeclampsia (PE) Risk
- Trial name
- PREEATH-T1D (NCT07479329)
- Where
- 2 sites in Spain
- Volunteers
- 1,300 people
- Sponsor
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
Abortion in First Trimester, Abortion Early
Research on Equity in Abortion Care by TeleHealth
This study will examine the ways in which telehealth for reproductive healthcare affects timing, costs, and follow-up care; whether telehealth reaches people in areas with greater health inequities; and the attributes of…
- Conditions
- Abortion in First Trimester, Abortion Early, Abortion; Attempted
- Trial name
- REACH (NCT06787274)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Fetus Disorder
AutoFUSE or First-Trimester Ultrasound Scan
The goal of this clinical trial is to validate the clinical application capabilities of AutoFUSE. The main questions it aims to answer are: Does AutoFUSE reduce the time required to obtain standard planes in first-trimester…
- Trial name
- NCT07601191
- Testing
- AutoFUSE system, Traditional ultrasound scan
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Ultrasound-guided Manual Vacuum Aspiration, First Trimester Spontaneous Abortion
Ultrasound-guided Manual Vacuum Aspiration (USG-MVA)
This is a retrospective study to review the current experience of USG-MVA in Hong Kong and also evaluate the effectiveness of USG-MVA in cytological analysis in the management of first trimester miscarriage.
- Trial name
- NCT05413525
- Testing
- ultrasound-guided manual vacuum aspiration (USG- MVA)
- Where
- 2 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Miscarriage in First Trimester
Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy
Early pregnancy loss happens when a pregnancy that is not developing properly is found on an ultrasound before 12 weeks and 6 days. This type of loss occurs in about 10% of pregnancies.
- Trial name
- NCT07088510
- Testing
- Hysteroscopic resection, Manual Vacuum Aspiration
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University Hospitals Cleveland Medical Center