Clinical trials: Pregnancy Loss, Early
Abortion Early
Very Early Medical Abortion
The research question begin addressed by this study is "Is Very Early Medical Abortion (VEMA - before a pregnancy is visible on ultrasound scan) as effective as medical abortion when performed later and an intrauterine pregnancy…
- Trial name
- VEMASCOT (NCT03989869)
- Testing
- Immediate treatment
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Completion of Medical Abortion
Use of Low Sensitivity Pregnancy Test for Self-assessment of Medical Abortion
The purpose of the study is to design a self-assessment package that could be the preferred option to a follow-up visit at the clinic by the majority of women having early medical abortion.
- Trial name
- m-Assist+ (NCT02231619)
- Testing
- Baseline verbal instruction on LSUPT
- Where
- South Africa
- Volunteers
- 525 people
- Sponsor
- University of Cape Town
Abortion in First Trimester, Abortion Early
A Patient Decision Aid for Method of Early Abortion: a Randomized Control Trial
Introduction: There are two options for women seeking early pregnancy termination in Canada; either surgical or medication abortion.
- Conditions
- Abortion in First Trimester, Abortion Early, Decision Aid, Clinical Decision-making
- Trial name
- NCT05182008
- Testing
- Decision aid, Usual care
- Where
- Canada
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Miscarriage, Early Pregnancy Loss
Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
About 1 to 3% of women of childbearing age suffer repeated early spontaneous miscarriages (RCF) defined by at least 3 fetal losses before 14 weeks of gestation.
- Trial name
- FALCO (NCT05557201)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spontaneous Abortion
Comprehensive Assessment of Risks for Miscarriage.
This study aims to determine the role of serum biomarkers and placental bloodflow in the comprehensive evaluation of the risk for spontaneous abortion
- Trial name
- MIS-CARE (NCT04456660)
- Testing
- Markers of ultrasound, Immunologic factors, Serum factors
- Where
- Bulgaria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Orthogyn Medical Center, Bulgaria
Recurrent Early Pregnancy Loss, Thyroid Diseases
Thyroxine Therapy for Recurrent Pregnancy Loss in Hypothyroid Women
The goal of this clinical trial is to investigate the influence of thyroxine supplementation on pregnancy outcomes in women with varying levels of Thyroid-Stimulating Hormone (TSH), who have experienced recurrent pregnancy loss…
- Trial name
- NCT06036576
- Testing
- Levothyroxine Pill
- Where
- Iraq
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Al-Kindy College of Medicine
Abortion Early
MA-ASAP at Independent Abortion Clinics: A Demonstration Project
In this study, the investigators propose to conduct a parallel study to MA-ASAP (ClinicalTrials.gov Identifier: NCT05278780) at an independent clinic.
- Trial name
- NCT05781061
- Testing
- Screening for Eligibility
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy Loss
Infections and Pregnancy Loss: Correlation Between Abortion and Silent Infections.
Correlation between the presence of intracellular viruses/bacteria and the incidence of miscarriage during the first trimester of pregnancy.
- Trial name
- NCT03585023
- Testing
- Spontaneous miscarriage, Voluntary pregnancy interruption
- Volunteers
- 200 people
- Sponsor
- University Hospital of Ferrara
Miscarriage, Breast Feeding
The Relationship Between Breastfeeding During Early Pregnancy and Miscarriage
Breastfeeding provides various health and psychological benefits to mothers and their babies. It also acts as an effective method of natural contraception when applied strictly for up to six months after birth.
- Trial name
- NCT05461963
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Siirt University
Spontaneous Abortion
Comparative Effectiveness of Pregnancy Failure Management Regimens
The purpose of the study is to compare the effectiveness of combination treatment (mifepristone premedication plus single-dose misoprostol) to single-dose misoprostol (standard of care) for the management of early pregnancy…
- Trial name
- PreFaiR (NCT02012491)
- Testing
- Misoprostol, Mifepristone
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Pennsylvania
Stillbirth, Perinatal Death
A Feasibility Randomised Control Trial to Evaluate Early Perinatal Bereavement Counselling for Parents Who Have Experienced a Perinatal Death
The goal of this feasibility randomised control trial is to determine if a trial to evaluate perinatal bereavement counselling for parents who have experienced a perinatal death is feasible.
- Conditions
- Stillbirth, Perinatal Death, Psychological, Grief
- Trial name
- PEARL-C (NCT07494760)
- Testing
- Bereavement Counselling, Usual bereavement care
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Pregnancy Loss, Early
Patient Satisfaction With the Management of a Stopped Pregnancy in the First Trimester
The clinical practice recommendations highlight the fact that the patient's choice concerning the management of her aborted pregnancy in the first trimester should be privileged, after clear and appropriate information on the…
- Trial name
- MYFEFACY (NCT05049980)
- Testing
- Medical treatment with Mifégyne® and MisoOne®, Endo-uterine aspiration
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Toulouse
Spontaneous Abortion, Oxidative Stress
Heavy Metals' Influence on Early Pregnancy Through Oxidative Stress
Patients with diagnosis of spontaneous abortion are enrolled in the cohort, in the cohort of patients who met the criteria, 3ml of whole blood intravenous and 5ml of urine were taken for heavy metal level examnation.
- Trial name
- NCT04003064
- Testing
- Blood
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Early Pregnancy Failure
Comparing Two Medical Treatments for Early Pregnancy Failure.
This study aims to compare whether a combination of two drugs (Mifepristone and misoprostol) are superior compared to using only one of these drugs (Misoprostol) as medical treatment for a miscarriage.
- Trial name
- Triple M (NCT03212352)
- Testing
- Mifepristone, Misoprostol
- Where
- 13 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Radboud University Medical Center
Fibroid, Miscarriage in First Trimester
Fibroids and the Risk of Miscarriage: a Prospective Observational Study in an Early Pregnancy Population
The aim of this observational study is to whether fibroids increase the risk of miscarriage in women in our early pregnancy population.
- Conditions
- Fibroid, Miscarriage in First Trimester, Miscarriage in Second Trimester
- Trial name
- FiRM (NCT06986616)
- Where
- United Kingdom
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Early Pregnancy Bleeding, Recurrent Pregnancy Loss
Maternal and Newborn Safety Profile of Progestogens in EARLY Pregnancy
This multinational, prospective, active surveillance, registry study following two cohorts will include study participants who are pregnant and seeking any type of medical treatment, including dydrogesterone and other…
- Trial name
- PEARLY (NCT05186779)
- Testing
- Progestagen
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Early Pregnancy Loss
Optimal Time Interval Between Mifepristone and Misoprostol Administration for Early Pregnancy Loss
A prospective cohort study to explore the optimal time interval between mifepristone and misoprostol administration for medical management of early pregnancy loss.
- Trial name
- TIME (NCT07506512)
- Testing
- 200mg mifepristone and 800mg misoprostol
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Pregnancy of Unknown Location, Ectopic Pregnancy
Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy
To further develop the patient care pathway for women classified with a pregnancy of unknown location (PUL) and ectopic pregnancy (EP).
- Conditions
- Pregnancy of Unknown Location, Ectopic Pregnancy, Early Pregnancy, Early Pregnancy Loss
- Trial name
- ABPEP (NCT04738370)
- Testing
- Sample collection
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
IUC Insertion After Medical Abortion
Intrauterine Contraception (IUC) After Medical Abortion
Today a large proportion of early abortions are medical, in accordance to the woman's choice. The main objective of the present study was to compare, in a randomised fashion, initiation of intrauterine contraception (IUC) at…
- Trial name
- NCT01537562
- Testing
- Timing of IUC insertion
- Where
- Sweden
- Volunteers
- 129 people
- Sponsor
- Karolinska Institutet
RECURRENT PREGNANCY LOSS
Sperm DNA Fragmentation in Recurrent Pregnancy Loss
In human, 2% of couples experimented Recurrent pregnancy loss (RPL). Currently, while etiological investigations were performed, 40 to 50 % of RPL were unexplained.
- Trial name
- PARTHOM (NCT02572154)
- Testing
- Blood and sperm samples
- Where
- 3 sites in France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse