Clinical trials: Preemptive Analgesia
Pain and Anxiety in Children With MIH
Preemptive Analgesia for Pain and Anxiety Control in Children With MIH
This randomized, triple-blinded clinical trial aims to evaluate the effect of preemptive analgesia using ibuprofen on pain perception and anxiety during restorative treatment of first permanent molars in children diagnosed with…
- Trial name
- NCT07374354
- Testing
- ibuprofen 100mg/ml oral suspension syrup
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- October University for Modern Sciences and Arts
Pain, Postoperative
Preemptive Local Anesthesia in Vaginal Surgery
Preemptive analgesia is an intervention which provides an anesthetic prior to initiating a painful stimulus. This trial is examining the effects of a local anesthetic given at the point of innervation prior to performing a…
- Trial name
- NCT00318292
- Testing
- bupivacaine and epinephrine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Myopes Who Have Undergone PRK.
Time Serial Analysis on Preemptive Analgesia of Preoperative Topical Diclofenac and Ketorolac in Photorefractive Keratectomy(PRK)
The investigators performed this study to investigate pain prevention of preoperative topical nonsteroidal anti-inflammatory drug (NSAID) in photorefractive keratectomy(PRK) using time serial pain scoring.
- Trial name
- NCT01761071
- Testing
- topical ketorolac 0.5% (Acular®, Allergan Inc, Irvine, CA), topical diclofenac 0.1% (Voltaren®, Novartis, Bern, Switzerland)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Yonsei University
Vitreoretinal Surgeries, Postoperative Nausea and Vomiting
Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS
The aim of this randomized trial is to assess the efficacy of preemptive analgesia using paracetamol or metamizole or both of them under SPI-guided anaesthesia for vitreoretinal surgery (VRS), presence of PONV (postoperative…
- Conditions
- Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain
- Trial name
- P&MSPIVRS (NCT03389243)
- Testing
- Metamizol, paracetamol, paracetamol and metamizole
- Where
- Poland
- Volunteers
- 165 people
- Sponsor
- Medical University of Silesia
Anterior Cruciate Ligament Injuries, Postoperative Pain
Multimodal Analgesia vs. Femoral Block in ACL Surgery
This study aims to compare the effects of a preemptive multimodal intravenous analgesia protocol and a femoral triangle block on early postoperative rehabilitation compliance in patients undergoing anterior cruciate ligament…
- Conditions
- Anterior Cruciate Ligament Injuries, Postoperative Pain, Pain, Postoperative
- Trial name
- MAPvsFTB (NCT06936995)
- Testing
- Preemptive Multimodal Intravenous Analgesia, Femoral Triangle Block
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Ankara University
Postoperative Delirium
The Effect of Bupivacaine Liposome Preemptive Analgesia on Postoperative Pain and Delirium in Elderly Patients Undergoing Hip Fracture Surgery
To explore the effects of bupivacaine liposomes in preemptive analgesia for iliofascial block on postoperative pain and postoperative delirium in elderly patients with hip fractures, to optimize perioperative analgesia…
- Trial name
- NCT07066111
- Testing
- Tramadol, bupivacaine liposome (ultrasound-guided high iliofascial space block)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Pain, Postoperative, Morbid Obesity
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
The purpose of this study is to determine if pre-incisional lidocaine injection, instilled liquid bupivacaine, intra-abdominal aerosolized bupivacaine, or post-operative bupivacaine injection is superior in post-operative pain…
- Trial name
- NCT00508976
- Testing
- Injected bupivacaine post-operatively, Streamed bupivacaine versus streamed normal saline, Aerosolized bupivacaine versus aerosolized saline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pinnacle Health System
Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch, Local Incision, Postoperative Pain
- Trial name
- NCT07591220
- Testing
- Loxoprofen Sodium Patch on the incision site, Loxoprofen Sodium Patch on the contralateral side
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative, Analgesia
Oral Pregabalin as Preemptive Analgesia in Abdominal Hysterectomy
Postoperative pain affects 80% of surgical patients and is one of the main negative symptoms resulting from surgery. It impairs the recovery of patient since it is related to chronic pain, nausea and vomiting and longer hospital…
- Conditions
- Pain, Postoperative, Analgesia, Gabapentin Adverse Reaction, Opioid Abuse
- Trial name
- NCT04495374
- Testing
- Pregabalin 300mg
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Universidade Federal de Alfenas
Erector Spina Plan Block, Preemptive Analgesia
Comparison of the Effect of Preemptive and Post-operative Erector Spina Plane Block on Intraoperative Opioid Consumption and Postoperative Analgesia in Patients Who Will Undergo Elective Thoracotomy Surgery, Guided by the Nociception Level Index (NoL)
The patients who will participate in the study will be determined and informed according to the inclusion and exclusion criteria, and the patients who signed the informed consent form will be included in the study.52 patients who…
- Conditions
- Erector Spina Plan Block, Preemptive Analgesia, Thoracotomy, Nociception Level Index(NoL)
- Trial name
- NCT05944523
- Testing
- Erector Spina Plan Block
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ankara University
Pediatric Cancer, Pain, Postoperative
Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries
Surgical trauma initiates multiple physiological mechanisms that cause postoperative pain. Postoperative pain has nociceptive, inflammatory, and neuropathic components.Inadequate relief of postoperative pain leads to significant…
- Trial name
- NCT03580980
- Testing
- Paracetamol and ketamine, Caudal levobupivacaine, Morphine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Enhanced Recovery After Surgery, Multimodal Analgesia
Enhanced Recovery After Surgery-Based Multimodal Preemptive Analgesia for Perioperative Management in Transarterial Chemoembolization of Intermediate-to-Advanced Hepatocellular Carcinoma
To evaluate the effectiveness of the combination of hydrochloride hydromorphone and flurbiprofen ester for post-TACE intravenous patient-controlled intravenous analgesia (PCIA).
- Conditions
- Enhanced Recovery After Surgery, Multimodal Analgesia, Real-world Study, Transarterial Chemoembolization
- Trial name
- NCT07315022
- Testing
- hydrochloride hydromorphone + flurbiprofen axetil, conventional analgesia
- Where
- China
- Volunteers
- 129 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Molar, Third
Pain and Trismus Control in Third Molar Surgery: Ibuprofen, Ketamine, and Their Combination
The goal of the clinical trial is to compare the efficacy of ibuprofen, ketamine, and their combination in managing postoperative pain and trismus following third molar surgery.
- Trial name
- NCT05923775
- Testing
- Impacted third molar surgey
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Cihan Topan
Pain, Postoperative
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered…
- Trial name
- NCT04790812
- Testing
- Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Post Endodontic Pain, Mechanical Detection Threshold
The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.
A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain.
- Conditions
- Post Endodontic Pain, Mechanical Detection Threshold, Mechanical Pain Threshold, Mechanical Pain Sensitivity
- Trial name
- NCT07400471
- Testing
- Pregabalin- Acetaminophen, Duloxetine- Acetaminophen
- Where
- Bangladesh
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Chattogram International Dental College
Obstetric Pain
Effect of Preemptive Epidural Analgesia in Labor on Cytokine Production
During labor there is an increased production of inflammatory mediators called cytokines. Higher concentration of certain cytokines has been linked to adverse neonatal and maternal outcomes.
- Trial name
- NCT00361712
- Testing
- Preemptive epidural analgesia, Standard of care
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Postoperative Pain, Acute
The Effect of Preemptive Pregabalin on Postoperative Pain and Respiratory Dynamics in Robotic Prostatectomy Operation.
The study aimed to investigate the impact of preemptive pregabalin on the postoperative pain severity and the requirement of analgesic drugs in patients undergoing robotic radical prostatectomy surgery as primary outcome.
- Trial name
- NCT06170359
- Testing
- robotic surgery under general anaesthesia
- Volunteers
- 90 people
- Sponsor
- Umraniye Education and Research Hospital
Post Operative Pain, Preemptive Analgesia
Paracetamol Plus Tramadol Versus Fentanyl in Day Case Surgeries
Postoperative pain is an important problem, especially for day case surgeries. It has negative effects on patient's hemodynamics and can cause delayed ambulation resulting in prolonged duration of hospital stay and poor patient…
- Trial name
- NCT05990686
- Testing
- tramadol plus paracetamol, Fentanyl Injection
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Uterine Fibroids, Uterine Artery Embolization
Preemptive Analgesia Following Uterine Artery Embolization
Uterine leiomyomata, also known as fibroids, are an extremely common benign lesion being present in 30-50% of all women. Traditional surgical treatment of symptomatic fibroids has been hysterectomy in post child bearing woman.
- Trial name
- NCT01555073
- Testing
- pregabalin/celecoxib
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Northwestern University
Flurbiprofen Axetil, Preemptive Analgesia
Effect of Preemptive Analgesia With Flurbiprofen Axetil on Perioperative Sleep Quality and Postoperative Pain in Patients Undergoing Laparoscopic Gynecological Surgery.
In humans and animals, circadian rhythm sleep cycle is an important function to maintain and regulate basic physiological homeostasis, such as cognitive function, glucose metabolism, memory consolidation, immune function and…
- Conditions
- Flurbiprofen Axetil, Preemptive Analgesia, Postoperative Pain, Perioperative Sleep Quality
- Trial name
- NCT04611763
- Testing
- Flurbiprofen axetil preoperatively, Flurbiprofen axetil postoperatively
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Beijing Friendship Hospital