Clinical trials: Prediabetes or Diabetes
Type II Diabetes Mellitus
Effects of a Spiced Meat Patty on Inflammation in Men With Type 2 Diabetes
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile…
- Trial name
- NCT01076829
- Testing
- Spice polyphenols
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prediabetes
Mitochondrial-related Platelet Transcript Expression Levels in Pre-diabetic Subjects Randomized to Metformin or Placebo
Diabetes mellitus (DM) imposes an approximate 2-fold increased risk of atherothrombosis. Patients with type 2 DM have a 2- to 4-fold increase in the risk of coronary artery disease (CAD) and atherothrombotic complications.
- Trial name
- MAP-2 (NCT02682121)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Utah
Stroke Recurrence, Type 2 Diabetes
Mobile Health Dietary Intervention for Stroke Survivors With Prediabetes or Type 2 Diabetes
Objectives: This study aims to test whether a mobile app called PortionSize Ed can help adults who have had a recent stroke and also have prediabetes or type 2 diabetes improve their diet.
- Conditions
- Stroke Recurrence, Type 2 Diabetes, Prediabetes
- Trial name
- NCT07120334
- Testing
- PortionSize Ed + MedDiet Support, Standard of care for Stroke and Prediabetes or T2D
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Hawaii
Overweight, Obesity
Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study)
Type 2 diabetes and prediabetes, which are mainly caused by a lack of physical activity and excess weight, put people at an increased risk of cardiovascular disease.
- Conditions
- Overweight, Obesity, Type 2 Diabetes, Prediabetes
- Trial name
- SHAPE3 (NCT00928005)
- Testing
- Weight loss diet, Weight loss diet plus exercise
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes, PreDiabetes
Effect of Selenium Supplementation on Glycemic Control in Patients With Type 2 Diabetes or Prediabetes
Although it has been suggested that selenium (Se) increases the risk of T2DM, most evidence comes from observational studies that cannot prove causality.
- Trial name
- NCT05320510
- Testing
- Se-yeast
- Volunteers
- 130 people
- Sponsor
- Huazhong University of Science and Technology
Cystic Fibrosis Related Diabetes
Use of the Insulin Pump in Cystic Fibrosis Patients With Impaired Glucose Tolerance or CFRD and in Type 1 Diabetes Patients.
We hypothesize use of the insulin pump will improve body weight, lean body mass, whole body protein turnover, hepatic glucose production (HGP), and blood sugar control in CF patients with impaired glucose tolerance or patients…
- Trial name
- NCT00287456
- Testing
- Insulin Pump, Insulin, Oral Glucose Tolerance Test
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Pre-hypertension, Pre-diabetes
Losartan Versus Hydrochlorothiazide in Reversing Remodeling of Small Arteries in Pre-Hypertensive Pre-Diabetic Subjects
This randomized, double-blind, parallel group, two-centre pilot study will test the hypothesis that subjects who are otherwise healthy but fulfill the criteria for a diagnosis of pre-hypertension and pre-diabetes will have…
- Trial name
- NCT00388388
- Testing
- losartan, hydrochlorothiazide
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Pre-Diabetes, Major Lung or Abdominal Surgery
Attenuating The Post-Operative Insulin Resistance And Promoting Protein Anabolism
Major surgery results in a stress- induced catabolic response, marked by post-operative insulin resistance, hyperglycemia and loss of body protein, which is associated with increased morbidity, mortality and adverse outcomes.
- Conditions
- Pre-Diabetes, Major Lung or Abdominal Surgery, Insulin Resistance
- Trial name
- NCT02393573
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Healthy, Overweight and Obesity
Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial
Health authorities recommend a reduction in added sugars from sugar-sweetened beverages (SSBs) due to risk of obesity and diabetes. As a sugar-reduction strategy, finding the ideal SSB replacement is of the utmost importance.
- Conditions
- Healthy, Overweight and Obesity, Metabolic Syndrome, PreDiabetes
- Trial name
- NCT03543644
- Testing
- Sugar-sweetened beverage (SSB), Non-nutritive sweetened beverages (NSB), Water
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Heart Failure, Type 2 Diabetes
Comparison of Eplerenone Versus Spironolactone in Heart Failure Patients With Glucose Intolerance or Type 2 Diabetes
In this proposal,the investigators will examine whether the selectivity of eplerenone for the MR will translate into a better glucose and metabolic profile compare to spironolactone in patients with HF with glucose intolerance or…
- Conditions
- Heart Failure, Type 2 Diabetes, Glucose Intolerance
- Trial name
- SNOW (NCT01586442)
- Testing
- Eplerenone, Spironolactone
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Montreal Heart Institute
Normoglycemia, Prediabetes
Effect of Chronic Exposure to Nextida GC-B on Glycemic Control in Adults With Normoglycemia or Prediabetes
The goal of this clinical trial is to investigate the safety and efficacy of Nextida GC-B on glycemic control in adults with normoglycemia and prediabetes.
- Conditions
- Normoglycemia, Prediabetes, Glycemic Control
- Trial name
- NCT07149064
- Testing
- Nextida GC-B
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Mild Cognitive Impairment, Alzheimer's Disease
BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2DM)
Mild Cognitive Impairment (MCI) represents a group of persons who are at risk of incident dementia in the near-term. Persons with MCI who have deficits in short-term recall (amnestic MCI) are at significant risk of incident…
- Trial name
- BDPP (NCT02502253)
- Testing
- grape seed polyphenolic extract, resveratrol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Overweight, Obesity
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight
This is a study of tirzepatide in participants with overweight and obesity. The main purpose is to learn more about how tirzepatide affects body weight. The study has two phases: A main phase and an extension phase.
- Trial name
- SURMOUNT-1 (NCT04184622)
- Testing
- Tirzepatide
- Where
- 118 sites in United States, Argentina and 8 more
- Volunteers
- 2,539 people
- Sponsor
- Eli Lilly and Company
PreDiabetes, Cardiovascular Diseases
Individualized Nutrition Therapy for Preventing or Delaying Onset of Type-2 Diabetes
The overall aim of this feasibility study is to conduct a randomized, controlled intervention providing adults with prediabetes either an individualized nutrition therapy (INT) intervention that contains individualized dietary…
- Trial name
- NCT05161897
- Testing
- Individualized Nutrition Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- George Mason University
Myocardial Infarction, Unstable Angina Pectoris
Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction
A three months, double-blind, randomised, parallel-group study evaluating the efficacy of sitagliptin (Januvia™) versus placebo on beta-cell function in patients with newly detected glucose abnormalities and acute myocardial…
- Conditions
- Myocardial Infarction, Unstable Angina Pectoris, Diabetes Mellitus, Impaired Glucose Tolerance
- Trial name
- BEGAMI (NCT00627744)
- Testing
- Sitagliptin
- Where
- 2 sites in Sweden
- Volunteers
- 85 people
- Sponsor
- Karolinska Institutet
Prediabetic State, Non-alcoholic Fatty Liver Disease
ORION: Effects of Cenicriviroc on Insulin Sensitivity in Subjects With Prediabetes or Type 2 Diabetes Mellitus (T2DM) and Suspected NAFLD
A Phase 2a, randomized, double-blind, placebo-controlled, multi-center study of cenicriviroc (CVC) to be conducted in approximately 50 adult obese subjects [body mass index (BMI) ≥ 30 kg/m^2] with prediabetes or type 2 diabetes…
- Conditions
- Prediabetic State, Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus
- Trial name
- NCT02330549
- Testing
- Cenicriviroc 150 mg
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 45 people
- Sponsor
- Tobira Therapeutics, Inc.
Type 2 Diabetes, Overweight or Obesity
Effect of Low-calorie Diets With Different Macronutrient Composition and Macronutrient Distribution in Shift Workers With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
Background and Aims: Shift work, particularly involving night shifts, is associated with increased risk of metabolic disturbances such as type 2 diabetes mellitus (T2DM).
- Conditions
- Type 2 Diabetes, Overweight or Obesity, PreDiabetes
- Trial name
- NCT06912555
- Testing
- Diet
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
Overweight, Diabetes
Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects w/o Type 2 Diabetes
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects without or with Type 2 Diabetes
- Conditions
- Overweight, Diabetes, PreDiabetes, Obesity
- Trial name
- LIGHT-UP (NCT03058029)
- Testing
- Gelesis200
- Where
- 30 sites in United States, Canada and 6 more
- Volunteers
- 300 people
- Sponsor
- Gelesis, Inc.
Impaired Glucose Tolerance, Diabetes
The Effects of Exercise on Adipokine in Impaired Fasting Glucose or Impaired Glucose Tolerance Patients
Many adipokines are thought that related with metabolic disturbance such as glucose intolerance, dyslipidemia, and insulin resistance.
- Trial name
- NCT00472342
- Testing
- exercise prescription
- Where
- South Korea
- Volunteers
- 182 people
- Sponsor
- Yonsei University
Impaired Fasting Glucose, Newly Diagnosed Type 2 Diabetes
Dietary Effects on Circulating Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity and Enzyme Activity in Peripheral Blood Mononuclear Cells (PBMCs) in Patients With Prediabetes or Newly Diagnosed Type 2 Diabetes
We determined the effects of dietary intervention (replacement of refined rice with whole grains and legumes and a high intake of vegetables) on circulating Lp-PLA2 activity and enzyme activity in peripheral blood mononuclear…
- Trial name
- NCT01895387
- Testing
- Dietary intervention-whole grains and legumes, Dietary intervention-Refined rice
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University