Clinical trials: Pragmatic Randomized Controlled Trial
Tension Headache
The Effectiveness of Pharmacopuncture on Acute Tension Headache
This study is a double blind, randomized controlled trail. condition/disease: acute tension headache treatment/intervention: Pharmacopuncture
- Trial name
- NCT05549765
- Testing
- Pharmacopuncture, Korean medical treatment
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Jaseng Medical Foundation
Older People
Reablement in Residential Aged Care - a Randomized Controlled Trail
Background: The global increase in older adults presents challenges for maintaining health and autonomy in residential aged care (RAC) facilities, where passivity has been shown to often diminish quality of life.
- Trial name
- Re-RAC (NCT06793501)
- Testing
- Reablement intervention, Control group
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- Region Örebro County
Depression
Study of Whether Educational Visits to Primary Care Professionals Improves the Quality of Care They Provide.
The purpose of this study is to find out whether educational visits by Pharmacists, who are already employed as advisers in health organisations, improve the prescribing habits of primary care doctors.
- Trial name
- NCT00393536
- Testing
- Educational outreach visiting
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- Newcastle University
Insomnia, Post Traumatic Stress Disorder
Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Frontline Health Care Workers (The HCW-CBTi Study)
The COVID-19 pandemic has resulted in increased workload and concerns about personal and family safety for frontline healthcare workers (HCWs), which can lead to decreased well-being and worsening mental health.
- Conditions
- Insomnia, Post Traumatic Stress Disorder, Anxiety Disorders, Depression
- Trial name
- HCW-CBTi (NCT05816304)
- Testing
- Digital Cognitive Behavioral Therapy for Insomnia (dCBTi)
- Where
- 2 sites in Canada
- Volunteers
- 366 people
- Sponsor
- University Health Network, Toronto
Edentulism
Clinical Performance Evaluation of Two Different Dental Implants
In brief, the aim of this randomized controlled trial is to evaluate the patient satisfaction and the clinical performance of two types of implants: 1) HA-coated hybrid dental implant and 2) non-coated moderately rough dental…
- Trial name
- HAHy-vs-C (NCT03845335)
- Testing
- dental implant-supported restoration
- Where
- 4 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Elite Odontoiatrica
Psychological Trauma, Stress Disorders, Post-Traumatic; Mental Disorders
Trauma-Focused Group Therapy for Adults With Trauma-Related Symptoms in Primary Care
Psychological trauma is common and can lead to long-lasting emotional distress, difficulties in daily functioning, and reduced quality of life.
- Trial name
- NCT07757334
- Testing
- Trauma-Focused Group Intervention, Treatment as Usual (TAU)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Luis Eduardo Estévez Cachafeiro
Treatment Adherence and Compliance
A Factorial Approach to Improve Treatment Adherence and Systolic Blood Pressure
In Pakistan, poor medication adherence is a key operational factor in the prevalence of uncontrolled hypertension. Mobile phone treatments based on technology are at the forefront and are a reasonably low-cost strategy for…
- Trial name
- NCT05106790
- Testing
- Educational support with peer counseling, mHealth intervention, mHealth intervention and Educational support with peer counseling
- Where
- 6 sites in Pakistan
- Volunteers
- 1,440 people
- Sponsor
- Universiti Putra Malaysia
Neurodevelopmental Disorders
Evaluation of the Effectiveness of Child-oriented Goal-setting in Paediatric Rehabilitation (the ENGAGE Approach)
Children with disabilities often access rehabilitation services to improve their abilities to participate in everyday activities.
- Trial name
- NCT05017363
- Testing
- ENGAGE
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- University of Alberta
Menopause, Menopause Related Conditions
World Digital Detox Program for Enhancing Women's Health & Well-being
The concept of a digital detox, involving a deliberate reduction or elimination of digital device usage, has emerged as a potential strategy to mitigate the adverse effects of technology on mental and physical well-being.
- Conditions
- Menopause, Menopause Related Conditions, Psychological Stress
- Trial name
- NCT06154798
- Testing
- World Digital Detox Women's Health Program
- Where
- India
- Volunteers
- 73 people
- Sponsor
- Innowage Limited
Hyponatremia, Syndrome of Inappropriate Antidiuresis
Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis
The goal of this study is to assess the impact of protein supplementation on hyponatremia caused by the syndrome of inappropriate antidiuresis during hospitalization.
- Trial name
- TREASUREx (NCT06821802)
- Testing
- Moltein PURE Protein Powder, Fluid restriction
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiovascular Diseases (CVD), Drug Effect
Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial
Statins inhibit hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase which catalyzes the rate-limiting step in cholesterol synthesis.
- Conditions
- Cardiovascular Diseases (CVD), Drug Effect, Atherosclerosis Cardiovascular Disease
- Trial name
- STATIN-C3 (NCT06856772)
- Testing
- Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)
- Where
- Denmark
- Volunteers
- 42,000 people
- Sponsor
- Tor Biering-Sørensen
Acute Respiratory Tract Infection, Urinary Tract Infections
Routine Antibiotic Prescription Monitoring in Primary Care Physicians: A Nationwide Trial
Antibiotic resistance is an increasingly serious problem in Switzerland which is associated with the exposure and overall uptake of antibiotics in a population.
- Trial name
- NCT03379194
- Testing
- Antibiotic stewardship program
- Where
- Switzerland
- Volunteers
- 3,426 people
- Sponsor
- University Hospital, Basel, Switzerland
Fibromyalgia, Diffuse Myofascial Pain Syndrome
Trial of Acupuncture in the Treatment of Fibromyalgia
Fibromyalgia is a medical condition characterized by musculoskeletal pain, fatigue, sleep disturbances and depression. It affects population at a socioeconomically active age and represents a burden for the patients and the…
- Conditions
- Fibromyalgia, Diffuse Myofascial Pain Syndrome, Fibromyalgia-Fibromyositis Syndrome, Fibromyositis-Fibromyalgia Syndrome
- Trial name
- NCT01189994
- Testing
- Acupuncture, Orientation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Santa Casa da Misericordia do Rio de Janeiro Hospital
Smoking, Smoking Cessation
Intervention Study for Smoking Cessation in Spanish College Students
This study evaluate the effectiveness of a nurse multi-component intervention aimed at helping Spanish college student smokers to quit smoking.
- Trial name
- NCT03448900
- Testing
- Multicomponent intervention, Brief advice
- Where
- Spain
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Affective Disorder, Psychosis
Value of Gym-based Exercise Training for Young Adults Receiving Antipsychotic Medication: The Vega Trial
This is a multicentre, pragmatic, randomised controlled trial to estimate the effect of a 4-month gym-based exercise training program on 1) patient-rated personal recovery (primary outcome), 2) Health-related quality of life…
- Trial name
- Vega (NCT05461885)
- Testing
- Supervised exercise
- Where
- 4 sites in Denmark
- Volunteers
- 226 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mental Disorder, COVID
Psychotherapy Strategies for the Treatment of Professionals and Students From Essential Services With High Levels of Emotional Distress in the Context of COVID-19
The study consists in a pragmatic superiority randomized controlled trial comparing different strategies of psychotherapy for professionals and students from essential services with high levels of emotional distress during the…
- Conditions
- Mental Disorder, COVID, Emotional Distress, Depression
- Trial name
- NCT04635618
- Testing
- Cognitive Behavioral Brief-Telepsychotherapy, Brief Interpersonal Telepsychotherapy, Telepsychoeducation
- Where
- Brazil
- Volunteers
- 999 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Alzheimer Disease, Dementia Alzheimers
An Electronic Clinical Decision Support Tool to Reduce Low-value Antipsychotic Prescriptions
The goal of this study will be to design, implement and test the impact of a quality improvement (QI) intervention that uses an EHR CDS tool among physicians newly ordering an antipsychotic medication for older adults with ADRD.
- Conditions
- Alzheimer Disease, Dementia Alzheimers, Dementia of Alzheimer Type
- Trial name
- NCT04851691
- Testing
- EHR CDS, Usual Care
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of California, Los Angeles
Coronary Artery Disease, Coronary Artery Bypass Grafting
CCTA-Based vs CAG-Based CABG: A Multicenter Pragmatic Non-Inferiority Trial
The goal of this clinical trial is to find out if using a non-invasive heart scan (called coronary computed tomography angiography, or CCTA) to plan coronary artery bypass grafting (CABG) works as well as the standard invasive…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Coronary Computed Tomography Angiography, Coronary Angiography (CAG)
- Trial name
- CtaCAB (NCT07769008)
- Testing
- CCTA-based CABG, CAG-based CABG
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Ruijin Hospital
Depression
Acupuncture Augmentation for Inpatients With Major Depression Disorder
Acupuncture practice is based on Traditional Chinese Medicine (TCM) principles of harmonization and balance, and the need to maintain unobstructed flow of energy (Qi) to attain efficient body functioning and metabolism so as to…
- Trial name
- NCT05452746
- Testing
- Acupuncture, Treatment as usual
- Where
- Singapore
- Volunteers
- 84 people
- Sponsor
- Institute of Mental Health, Singapore
Anemia
Pilot Optimizing Transfusion Thresholds in Critically-ill Children With Anaemia
The Pilot Optimizing Transfusion Thresholds in Critically-ill Children with Anaemia (P-OpTTICCA) study is a pilot trial for a large pragmatic international parallel open-label non-inferiority randomised controlled trial.
- Trial name
- P-OpTTICCA (NCT03871244)
- Testing
- Less red blood cell transfusions, More red blood cell transfusion (standard transfusion strategy in PICU)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- St. Justine's Hospital