Clinical trials: Postoperative Use of Analgesics
Intravenous Drug Usage, Ibuprofen
Postoperative Analgesic Effects of Ibuprofen Versus Ketorolac in Patients Undergoing in Orthopedic Surgery
Objectives: To compare the postoperative analgesic effects of ibuprofen versus ketorolac in patients undergoing orthopedic surgery at Combined Military Hospital, Rawalpindi.
- Conditions
- Intravenous Drug Usage, Ibuprofen, Ketorolac, Knee Arthroscopy
- Trial name
- NCT05695664
- Testing
- Ibuprofen 800 mg, Ketorolac Injection
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Benazir Bhutto Hospital, Rawalpindi
Opioid Use, Postoperative Pain
Comparing Intrathecal Morphine With Modified Thoracoabdominal Nerve Block Through Perichondral Approach in Major Abdominal Surgery
Abdominal surgery causes severe postoperative pain due to retraction of the abdominal wall and direct manipulation of visceral organs. It leads to delayed postoperative recovery, increased postoperative morbidity and mortality.
- Trial name
- NCT06346860
- Testing
- Regional Block Comparison
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Marmara University
Postdural Puncture Headache
Effect of Coffee on Postdural Puncture Headache After Cesarean Section
The purpose of this study is to investigate the effects of postoperative coffee consumption on postdural puncture headache (PDPH) and analgesic use in women undergoing cesarean section with spinal anesthesia.
- Trial name
- NCT07410741
- Testing
- Coffee Consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Breast Cancer, Postoperative Pain
Preoperative Sleep Quality and Postoperative Outcomes in Breast Surgery
Brief Summary: This prospective, single-center observational study examined the association between preoperative sleep quality and postoperative outcomes in women undergoing elective breast cancer surgery.
- Conditions
- Breast Cancer, Postoperative Pain, Inflammation
- Trial name
- NCT07547774
- Testing
- Preoperative Sleep Quality Assessment (PSQI)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Arthroscopy
Effect of Celecoxib Versus Placebo Before and After Knee Surgery on the Overall Use of Analgesics After Surgery
To compare the total analgesic use at 24 hours after arthroscopic knee surgery in patients treated with celecoxib versus placebo.
- Trial name
- NCT00633386
- Testing
- Celecoxib
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Postcraniotomy Headache, Intraoperative Analgesic Use
Diclofenac Administered Before Skull Operations Reduces the Severity of Headache After the Intervention
Purpose: According to the proposal of the International Headache Society acute postcraniotomy headache (PCH) is defined as a headache of variable intensity, being most serious at the site of surgical intervention and developing…
- Conditions
- Postcraniotomy Headache, Intraoperative Analgesic Use, Postoperative Analgesic Use, Postoperative Complications
- Trial name
- NCT01907984
- Testing
- Diclofenac, Midazolam
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- University of Debrecen
Pain, Postoperative, Opioid Use
Comparison of Postoperative Nociception Between NOL-guided and Standard Intraoperative Analgesia Based on Fentanyl
Pain is defined as an unpleasant sensory and emotional conscious experience, associated with actual or potential tissue damage. Nociception is the sympathetic response to noxious stimuli during unconsciousness.
- Conditions
- Pain, Postoperative, Opioid Use, Nociceptive Pain, Postoperative Pain
- Trial name
- NOLFentanyl (NCT03858621)
- Testing
- fentanyl NOL guided
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Victor Contreras, MSN
Opioid Use Disorders, Opioid-related Disorders
Prevalence and Predictors of Prolonged Post-surgical Opioid Use: a Prospective Observational Cohort Study
Post-surgical opioid prescribing intended for the short-term management of acute pain may lead to long-term opioid use, and its associated harms.
- Conditions
- Opioid Use Disorders, Opioid-related Disorders, Surgery, Pain, Postoperative
- Trial name
- NCT02571400
- Testing
- Continued use of opioid analgesics >90 days post-surgery
- Where
- Australia
- Volunteers
- 1,013 people
- Sponsor
- University of Notre Dame Australia
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Obstructive Sleep Apnea
Dex as Analgesic Adjuvant in OSA Patients
The purpose of this study is to assess whether intravenous peri-operative Dexmedetomidine reduces opioid requirements and or improves pain control after Uvulopalatopharyngoplasty (UPPP) in patients with obstructive sleep apnea…
- Trial name
- NCT03613558
- Testing
- Dexmedetomidine
- Where
- United States
- Sponsor
- Montefiore Medical Center
Pain, Postoperative, Anxiety
Effect of VR on Anxiety and Pain in Gynecological Surgery
Rationale: Lack of postoperative acute pain management is associated with increased morbidity, longer recovery time, more opioid use and subsequently increased health care costs.
- Conditions
- Pain, Postoperative, Anxiety, Pain Catastrophizing, State Anxiety
- Trial name
- VRAP-G (NCT04687501)
- Testing
- Virtual Reality
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Zuyderland Medisch Centrum
Post-operative Pain, Colon Cancer
The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery
The purpose of the study is to evaluate the effect of Exparel on pain control and patient outcome after colon resection. The investigators will evaluate the clinical course of the patients who receive exparel as compared to the…
- Conditions
- Post-operative Pain, Colon Cancer, Diverticulitis
- Trial name
- NCT02052557
- Testing
- Bupivacaine, Bupivacaine liposome suspension
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Des Moines University
Herniated Lumbar Disc
Postoperative Pain and Analgesic Use Following Lumbar Discectomy: A Comparative Study of Endoscopic Surgery and Open Surgery
The lifetime prevalence of lumbosacral radiculopathy is 3 to 5 percent. The most common cause is a lumbar disc herniation. In 10 to 20 percent of patients, medical treatment is insufficient, and surgery is recommended.
- Trial name
- DISCOPAIN (NCT07766031)
- Testing
- Endoscopic surgery, Open surgery
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Saint-Gregoire Private Hospital Center
Opioid Use, Unspecified, Pain, Postoperative
Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery
Being relatively new, the NOL monitor may offer interesting observations in perioperative nociception levels and appropriate analgesic consumption in diverse surgeries, including robot-assisted surgery.
- Trial name
- NCT05662371
- Testing
- Nociception Level monitor (NOL), Standard care
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Southern Denmark
Total Joint Arthroplasty
The Effect of Guided Imagery Technique on Anxiety, Pain, and Analgesic Use in Total Joint Arthroplasty Patients
This randomized controlled study will investigate the effects of guided imagery on preoperative anxiety and postoperative pain and analgesic consumption in patients undergoing total joint arthroplasty.
- Trial name
- NCT07194252
- Testing
- Guided imagery technique application
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Ankara Yildirim Beyazıt University
Postherpetic Neuralgia
Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Postherpetic Neuralgia
The purpose of this study is to determine whether KAI-1678 is effective in the treatment of postherpetic neuralgia pain
- Trial name
- NCT01106716
- Testing
- KAI-1678, Lidocaine
- Where
- Australia
- Volunteers
- 23 people
- Sponsor
- KAI Pharmaceuticals
Arthroscopy
Effect of Celecoxib Versus Placebo Before and After Knee Surgery on Overall Use of Analgesics After Surgery
To compare total analgesic use at 24 hours after arthroscopic knee surgery in celecoxib-treated versus placebo-treated patients
- Trial name
- NCT00633438
- Testing
- Celecoxib
- Where
- 18 sites in United States
- Volunteers
- 204 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pain, Postoperative, Disability Physical
Effects of Interpectoral-Pectoserratus Plane Block After Breast Cancer Surgery
The aim of this study: It was aimed to observe the effects of intraoperative and preoperative PECS II block on postoperative pain, amount of analgesic use and shoulder joint range of motion in patients who underwent breast cancer…
- Conditions
- Pain, Postoperative, Disability Physical, Quality of Life
- Trial name
- NCT05568589
- Testing
- Preoperative Interpectoral - Pectoserratus Plane Block, Intraoperative Interpectoral - Pectoserratus Plane Block, Non Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Bakircay University
Hysterectomy, Post Operative Analgesia
Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use
The purpose of this study is to determine whether an injection of a local anesthetic (Bupivacaine with epinephrine) in the vaginal cuff prior to closure would result in less immediate postoperative pain medication and increase…
- Trial name
- NCT06719180
- Testing
- Bupivacain
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- MediSys Health Network
Pain
Local Infiltration Analgesia After Abdominal Hysterectomy
The aim of the study is to evaluate traditional analgesic therapy after abdominal hysterectomy with single infiltration of local anesthetics in the surgical area at the end of surgery.
- Trial name
- LIA (NCT01782781)
- Testing
- ropivacaine, ketorelac and epinephrine
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University