Clinical trials: Postoperative Pain Breast Reduction
Pain, Postoperative, Obesity
Bilateral Thoracic Paravertebral Blocks in Obese and Non-obese Patients Undergoing Reduction Mammaplasty
Aim: Although regional anesthesia (RA) techniques are advantageous in the anesthetic management of obese patients (body mass index (BMI)≥30); their performances can still be associated with technical difficulties and greater…
- Conditions
- Pain, Postoperative, Obesity, Thoracic Paravertebral Blocks, Ultrasound
- Trial name
- NCT04596787
- Testing
- Bilateral Thoracic paravertebral block
- Volunteers
- 82 people
- Sponsor
- Istanbul University
Breast Reduction, Breast Reconstruction
Toradol (Ketorolac) in Breast Surgery to Reduce Pain & Opioid Use
The purpose of this study is to investigate whether perioperative single-dose administration of ketorolac (Toradol) can reduce post-operative pain after breast surgery, thereby decreasing post-operative opioid use.
- Trial name
- NCT04439396
- Testing
- Ketorolac Tromethamine, Saline
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Carilion Clinic
Stage II and III Breast Cancer
Melatonin as Adjuvant Therapy in Breast Cancer Patients
The study evaluate the effect of melatonin in improving quality of life and reducing post operative pain and chemotherapy-induced toxicity in breast cancer patients.
- Trial name
- MIQOL-B (NCT01557478)
- Testing
- Melatonin
- Where
- 2 sites in Thailand
- Volunteers
- 166 people
- Sponsor
- Khon Kaen University
Pain, Acute, Nausea
Enhanced Recovery Strategies in Elective Breast Surgery
Postoperative pain, nausea, and vomiting are frustrating sequelae of elective breast surgery. Poorly managed postoperative pain can lead to increased opioid use, increased postoperative nausea and vomiting (PONV), delayed return…
- Conditions
- Pain, Acute, Nausea, Vomiting, Postoperative, Opioid Use
- Trial name
- NCT03187080
- Testing
- Paravertebral block procedure using either local anesthetic (0.25% bupivacaine) or sterile saline, Enhanced recovery after breast surgery (ERABS) strategies, Paravertebral block using local anesthetic
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Mastectomy
Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy
The purpose of this study is to see if pre-operative regional nerve blocks compared to a placebo nerve block can decrease chronic post mastectomy pain, immediate postoperative pain and postoperative narcotic consumption.
- Conditions
- Breast Cancer, Mastectomy, Anesthesia, Local, Narcotic Use
- Trial name
- RELIEF (NCT04019834)
- Testing
- regional nerve block with local anesthesia of bupivacaine with steroid
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain, Postoperative
Ultrasound-Guided Thoracic Paravertebral Blocks in Patients Undergoing Reduction Mammoplasty
Background: Thoracic paravertebral blocks (TPVBs) have been effective for postoperative analgesia in mastectomy, thoracic and video-assisted thoracic surgeries.
- Trial name
- NCT02671851
- Testing
- Thoracic paravertebral blocks (TPVBs), IV metamizole sodium, paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul University
Breast Pain, Post-Op Complication
Serratus and Parasternal Infrapectoral Block for Breast Surgery.
Effective pain control is important following breast surgery as it improves quality of recovery, decreases the risk of chronic pain development and reduction of overall health care cost.
- Trial name
- NCT03708302
- Testing
- Unilateral serratus plane block, Unilateral parasternal infrapectoral block
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Western University, Canada
Pain, Postoperative
Opioid Counseling in Pain Management
The purpose of this study is to evaluate the effect of perioperative opioid counseling within a specific group of patient population who are undergoing bilateral reduction mammoplasty.
- Trial name
- NCT03985358
- Testing
- Opioid counseling plus standard of care instructions
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Pain, Postoperative, Hernia, Ventral
An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries
This is a multicenter, Phase 3, open-label, safety, tolerability, and characterization of pharmacokinetics study of the INL 001 (bupivacaine HCl) implant, at 300 mg, in patients following various soft-tissue surgeries: open…
- Conditions
- Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy
- Trial name
- NCT04785638
- Testing
- INL-001 (bupivacaine hydrochloride) implant
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Innocoll
Persistent Postsurgical Pain, Breast Cancer Female
Preventing Persistent Pain and Reducing Depressive and Anxious Symptoms Following Mastectomy and Lumpectomy
The proposed study will be a pilot randomized controlled trial comparing treatment as usual (TAU) to treatment as usual plus a brief Acceptance and Commitment Therapy (ACT) intervention (TAU + ACT) with mastectomy and lumpectomy…
- Conditions
- Persistent Postsurgical Pain, Breast Cancer Female, Ductal Carcinoma in Situ
- Trial name
- NCT03430765
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Katherine Hadlandsmyth
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Postoperative Analgesia in Breast Reduction Surgery, Postoperative Pain
Comparison of Serratus Plane Block and Rhomboid Intercostal Plane Block for Postoperative Analgesia in Breast Reduction Surgery
This prospective, randomized clinical study aims to compare the analgesic efficacy of serratus plane block (SPB) and rhomboid intercostal plane block (RIPB) for postoperative analgesia in patients undergoing elective bilateral…
- Conditions
- Postoperative Analgesia in Breast Reduction Surgery, Postoperative Pain, Postoperative Pain Breast Reduction, Pain, Postoperative
- Trial name
- SAPB-RIPB (NCT07229092)
- Testing
- Serratus Anterior Plane Block (SAPB), Rhomboid Intercostal Plane Block (RIPB), No Regional Block (Control)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Konul Karaja
Breast Hypertrophy, Pain, Postoperative
Ultrasound Guided Bilateral Erector Spinae Plane Block Versus Tumescent Anesthesia
In breast reduction surgery, pain control is usually performed with tumescent anesthesia, thoracic epidural anesthesia, intercostal nerve blocks and paravertebral block applications.
- Trial name
- NCT03558880
- Testing
- Erector Spinae Plane Block, Tumescent Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Chronic Pain Post-Procedural
Block REducing Pain After Surgery Trial
This observational study evaluates difference in chronic pain after six months from surgery between patients who received PECS block and general anesthesia versus general anesthesia alone.
- Trial name
- BREAST (NCT03448913)
- Testing
- PECS block
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- University of Padova
Nerve Blocks, Breast Surgery
Efficacy of Pectoral Nerve Block for Breast Reduction Surgery
The purpose of the study is to evaluate the efficacy of PECS block applied to patients undergoing bilateral breast reduction surgery on postoperative analgesia compared to local infiltration anesthesia.
- Conditions
- Nerve Blocks, Breast Surgery, Postoperative Pain
- Trial name
- NCT03857386
- Testing
- PECS group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Antalya Training and Research Hospital
Pain, Postoperative
Single and Double Injection Bilateral Thoracic Paravertebral Blocks in Reduction Mammaplasty
This study compares the analgesic effects and dermatomal blockade distributions of single and double injection bilateral thoracic paravertebral block (TPVB) techniques in patients undergoing reduction mammaplasty.
- Trial name
- NCT04517331
- Testing
- Thoracic paravertebral block-single injection, Thoracic paravertebral block-double injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pain, Postoperative
Gradual Withdrawal of Remifentanil Infusion Reduced Postoperative Pain and Opioid Requirement During Breast Surgery
Although remifentanil provides profound analgesia during operation, postoperative occurrence of hyperalgesia and tolerance after remifentanil administration could be a challenge to the postoperative pain control.
- Trial name
- NCT03756233
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Pain
Bupivacaine Pain Pumps to Decrease Mastectomy Post-Operative Pain
This double-blind, randomized, controlled clinical trial comparing patient-reported pain and pain medication/narcotic use between patients randomized to treatment (bupivacaine) or placebo (saline) delivered via pain pump to the…
- Trial name
- NCT01494259
- Testing
- Bupivacaine, Saline
- Where
- United States
- Sponsor
- Johns Hopkins University
Post Operative Pain, Opioid-Related Disorders
Erector Spinae Plane Block Versus Serratus Anterior Plane Block
the aim of the study compare the analgesic effect of erector spinae block and serratus anterior block in breast surgery
- Trial name
- NCT06862752
- Testing
- erector spine plane (ESP) block, Serratus Anterior Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Breast Reduction, Postoperative Pain
Parasternal Block Added to Serratus Anterior Plane Block in Breast Reduction Surgery
This study aims to evaluate the effect of adding a Superficial Parasternal Intercostal Plane Block (PIPB) to the Serratus Anterior Plane Block (SAPB) on postoperative pain control in patients undergoing breast reduction surgery…
- Conditions
- Breast Reduction, Postoperative Pain, Opioid Consumption
- Trial name
- NCT07432256
- Testing
- Serratus Anterior Plane Block (SAPB), Serratus Anterior Plane Block (SAPB) and parasternal intercostal plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Zonguldak Bulent Ecevit University