Clinical trials: Postoperative Cognitive Dysfunction (POCD)
PND, POCD - Postoperative Cognitive Dysfunction
Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery
As life expectancy increases, the rate of disability among elderly individuals is also rising. Elderly patients undergoing home-based rehabilitation after surgery without medical supervision may experience complications and…
- Trial name
- NCT07895407
- Testing
- Ciprofol, propofol
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery
PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery
This prospective observational study aims to evaluate whether intraoperative venous-to-arterial carbon dioxide partial pressure difference (PCO₂ gap) and arterial lactate levels can serve as early predictors of postoperative…
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07843186
- Volunteers
- 185 people
- Sponsor
- Ain Shams University
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Postoperative Cognitive Dysfunction (POCD), Controlled Hypotension for Nasal Surgeries
Comparison of Desflurane, Sevoflurane, and Total Intravenous Anesthesia in Ear Surgery Under Controlled Hypotension
This randomized prospective study aimed to compare desflurane, sevoflurane, and total intravenous anesthesia methods in patients undergoing elective ear surgery under controlled hypotension, with a particular focus on…
- Trial name
- POCD-ENT (NCT07792759)
- Testing
- Desflurane, Sevoflurane, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Postoperative Delirium, Postoperative Recovery in Elderly Patients
Recovery After Upper Extrimety Surgery
The goal of this randomized clinical trial is to determine whether Bispectral Index (BIS)-guided general anesthesia improves postoperative cognitive recovery and overall quality of recovery in adults undergoing elective hand or…
- Conditions
- Postoperative Delirium, Postoperative Recovery in Elderly Patients, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- Recovery (NCT07714928)
- Testing
- BIS-Guided General Anesthesia, Clinically Guided General Anesthesia
- Where
- Sweden
- Volunteers
- 112 people
- Sponsor
- Region Örebro County
Postoperative Cognitive Dysfunction (POCD)
Intravenous Anesthesıa and Cognıtıve Functıon ın Spınal Surgery
The aim of this study is to investigate the effect of these two different intravenous infusion techniques [manuel controlled infusion (MCI) and Target controlled Infusion( TCI)] on POCD.
- Trial name
- NCT07701187
- Testing
- Manuel controlled infusion group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Postoperative Cognitive Dysfunction (POCD), Cognitive Change
Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty
- Trial name
- NCT07598552
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Postoperative Cognitive Dysfunction (POCD)
Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting
This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery.
- Trial name
- OPCAB-POCD (NCT07643194)
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Anzhen Hospital
POCD - Postoperative Cognitive Dysfunction, Recovery Time
The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy
In this study, the investigators want to examine the effects of intravenous anesthetic drugs and gases on cognitive functions in the postoperative period in individuals who will undergo surgery for obesity.
- Conditions
- POCD - Postoperative Cognitive Dysfunction, Recovery Time, Postoperative Neurocognitive Disorder, Postoperative Delirium
- Trial name
- NCT07637357
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD)
Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)
Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Despite improved procedural outcomes, neurocognitive complications such as postoperative delirium (POD) and postoperative…
- Conditions
- Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD), Delirium - Postoperative, Neurocognitive Disorders
- Trial name
- HVU-NEURO (NCT07626567)
- Volunteers
- 500 people
- Sponsor
- Heart and Brain Research Group, Germany
Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD)
Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery
Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.
- Conditions
- Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD), Postoperative Acute Kidney Injury, Postoperative Morbidity
- Trial name
- NCT07510711
- Testing
- Continuous intraoperative monitoring of MAP and rSO₂; observational study with no therapeutic intervention.
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Postoperative Cognitive Dysfunction (POCD), Cardiac Diseases Requiring Surgery
Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study
This is a prospective cohort study aiming to construct a prediction model for postoperative cognitive dysfunction (POCD) in elderly cardiac patients. We plan to enroll elderly patients aged ≥65 years undergoing cardiac surgery.
- Trial name
- NCT07483047
- Where
- China
- Volunteers
- 634 people
- Sponsor
- Shanghai Geriatric Medical Center
POCD - Postoperative Cognitive Dysfunction, Mechanical Bowel Preparation
Investigation of the Effect of Preoperative Bowel Cleansing on Postoperative Cognitive Impairment
Cognitive impairment has been reported up to 54 % after colorectal surgeries. Mechanical bowel cleansing means that a system called the second brain in the body, which includes a wide variety of genetic and neuronal structures…
- Trial name
- NCT05942404
- Testing
- mechanical bowel preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- TC Erciyes University
Postoperative Delirium, Cerebral Oxygen Saturation
Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation
This study compares the effects of ibuprofen administered during surgery and within the first 24 hours after surgery, versus no ibuprofen, on cerebral oxygenation, postoperative changes in consciousness (postoperative delirium…
- Conditions
- Postoperative Delirium, Cerebral Oxygen Saturation, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- NCT07399184
- Testing
- ibuprofen
- Volunteers
- 54 people
- Sponsor
- Ondokuz Mayıs University
Delirium - Postoperative, Delirium and Post-operative Cognitive Dysfunction (POCD)
Audio-Recorded Messages Delivered Via iPad to Prevent Delirium in Hip Fracture Patients
The goal of this pilot clinical trial is to learn if personalized audio-recorded reorientation messages can be successfully implemented in general hospital wards for elderly patients after hip fracture surgery.
- Conditions
- Delirium - Postoperative, Delirium and Post-operative Cognitive Dysfunction (POCD), Delirium, Postoperative
- Trial name
- NCT07396532
- Testing
- Audio-Recorded Reorientation Intervention
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Condition / Focus: Postoperative Cognitive Dysfunction (POCD) Following Spinal Surgery
COMPARISON OF SEVOFLURANE AND PROPOFOL ADMINISTRATION ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN SPINAL SURGERY USING THE MINI-MENTAL STATE EXAMINATION (MMSE)
This study aims to compare the effects of two commonly used anesthetic agents, sevoflurane and propofol, on cognitive function after spinal surgery.
- Trial name
- SEVO-PROP-MMSE (NCT07378878)
- Testing
- Sevoflurane Administration, Propofol Administration
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Sumatera Utara
Thoracic Anesthesia, Geriatric Anesthesia
The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients
One lung ventilation (OLV) is commonly used in thoracic surgery. Although the lack of ventilation of the lung in the surgical area (independent lung) during OLV redirects pulmonary blood flow to the dependent lung, shunt…
- Conditions
- Thoracic Anesthesia, Geriatric Anesthesia, One Lung Ventillation (OLV), POCD - Postoperative Cognitive Dysfunction
- Trial name
- NCT07339124
- Testing
- Cognitive Remediation, Pain Medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Postoperative Cognitive Dysfunction (POCD), Neurocognitive Function
Target-Controlled Infusion and Postoperative Neurocognitive Outcomes in Geriatric Patients
This prospective observational study aims to evaluate the effects of target-controlled infusion (TCI) on postoperative neurocognitive function in geriatric patients undergoing major non-cardiac surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Neurocognitive Function, Sedation and Analgesia, Geriatric Patients
- Trial name
- TCI-NEURO (NCT07311447)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namigar Turgut
Neurocognitive Disorder, Dexmedetomidine Infusion
Effects of Dexmedetomidine on Postoperative Neurocognitive Disorder
This prospective study involves assessing neurocognitive function in patients undergoing laparotomic gastrointestinal surgery. Mini Mental state Assessment test and Mini-Cog tests will be conducted at multiple intervals…
- Conditions
- Neurocognitive Disorder, Dexmedetomidine Infusion, Postoperative Cognitive Dysfunction, Postoperative Cognitive Dysfunction(POCD)
- Trial name
- NCT06689137
- Testing
- mini mental state assessment test, mini-cog test
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Haseki Training and Research Hospital