Clinical trials: Postoperative Cognitive Dysfunction, active
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Cognitive and Behavioral Impairment
Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment
This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD).
- Trial name
- NCT07135336
- Testing
- surgery, norma
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University Shenzhen Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients
Elderly patients undergoing transurethral resection are at increased risk of postoperative cognitive dysfunction (POCD) and delirium, which are associated with prolonged hospital stay, increased morbidity, and decreased quality…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Dysfunction
- Trial name
- POCDTURMSTUD (NCT07719712)
- Testing
- Cognitive and Delirium Assessment (MoCA and CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Muğla Sıtkı Koçman University
Cognitive Decline, Urinary Bladder Cancer
Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor
Bladder tumor is one of the most widespread tumors in the world, with increasing prevalence at the global level. One of the procedures in patients with bladder tumors is transurethral resection of the bladder (TURM) most often…
- Conditions
- Cognitive Decline, Urinary Bladder Cancer, Frail, Biomarker
- Trial name
- NCT07165236
- Where
- Croatia
- Volunteers
- 42 people
- Sponsor
- Osijek University Hospital
Prehabilitation
Cognitive and Physical Optimization in Prevention of Postoperative Cognitive Deficit in Elderly With Lung Resection
Postoperative cognitive deficit and its connection with surgery and general anesthesia were first mentioned in the literature in 1955 by Bradford.
- Trial name
- COGNITION (NCT06339268)
- Testing
- Cognitive training, CogniFit App
- Where
- Serbia
- Volunteers
- 120 people
- Sponsor
- Military Medical Academy, Belgrade, Serbia
Postoperative Cognitive Dysfunction
Optic Nerve Sheath Diameter and Cognitive Outcomes in Bentall Surgery
Bentall surgery is a major cardiac procedure involving replacement of the ascending aorta, aortic root, and aortic valve, typically requiring cardiopulmonary bypass (CPB) and sometimes deep hypothermic circulatory arrest (DHCA).
- Trial name
- ONCOB (NCT07452367)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Postoperative Cognitive Dysfunction, Alzheimer Disease
Tau Pathology in the Brain After Hip or Knee Replacement Surgery
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease.
- Conditions
- Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies, Neuroinflammation
- Trial name
- TAU-PET (NCT07871487)
- Testing
- Hip or Knee Arthroplasty Under Spinal Anesthesia
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University Hospital
PND, POCD - Postoperative Cognitive Dysfunction
Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery
As life expectancy increases, the rate of disability among elderly individuals is also rising. Elderly patients undergoing home-based rehabilitation after surgery without medical supervision may experience complications and…
- Trial name
- NCT07895407
- Testing
- Ciprofol, propofol
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Postoperative Neurocognitive Dysfunction, Cognitive Dysfunction
Perioperative IL-33 is Associated with the Early Stage of Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery
Perioperative neurocognitive dysfunction(PND) are common complications of major surgery among patients, could be a long-term disease, which sometimes lasts for several years, and it is meaningful to find a biomarker of PND at the…
- Conditions
- Postoperative Neurocognitive Dysfunction, Cognitive Dysfunction, Postoperative Complications, Neuropsychological Tests
- Trial name
- NCT06704451
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Postoperative Cognitive Disorders
Impact of Combined PSi + NIRS Monitoring in the Prevention of Postoperative Cognitive Disorders in Cardiac Surgery.
Advances in cardiac medicine and anesthesia have made it possible to expand the indications for open heart surgery to increasingly older and more complex patients.
- Trial name
- NCT07267416
- Testing
- NIRS (Near Infrared Spectroscopy), SedLine®
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Brugmann University Hospital
Epilepsy
Evaluation of the Risk of Cognitive Deficit After Surgery of Epilepsy by Dynamic Spectral Imaging (ISD) of the Cognitive Functions in Patients Explored in StereoElectroEncephaloGraphy (SEEG)
Epilepsy affects between 0.5 and 0.7% of the European population. Despite the availability of numerous drug treatments, one third of patients still have seizures, which are associated with significant cognitive and social…
- Trial name
- ISD SEEG (NCT03094312)
- Testing
- Dynamic Spectral Imaging (ISD)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone
The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal…
- Trial name
- NCT07392840
- Volunteers
- 50 people
- Sponsor
- Minia University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- CogCheck-Valid (NCT03360838)
- Testing
- CogCheck
- Where
- Switzerland
- Volunteers
- 475 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Cognitive Dysfunction (POCD), Cognitive Change
Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty
- Trial name
- NCT07598552
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Postoperative Cognitive Dysfunction
Retrospective Evaluation of POCD Data of Studies From KAI, Charité - Universitätsmedizin Berlin
Data on prevention of perioperative neurocognitive disorders (pNCDs) are limited. The purpose of this monocentric parallel - grouped observational registry is to collect study data from studies with pNCDs as primary or secondary…
- Trial name
- NCT02832193
- Where
- 2 sites in Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Postoperative Delirium, Postoperative Cognitive Dysfunction
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
- Trial name
- TURBO (NCT04523909)
- Testing
- Trajectory of neuroinflammatory proteins in CSF and blood
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch
Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery
The purpose of this study is to compare remimazolam- and propofol-based anesthesia for their effects on postoperative cognitive dysfunction in patients undergoing aortic arch surgery.
- Conditions
- Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch, Aortic Arch Disease, Postoperative Delirium (POD)
- Trial name
- NCT07816068
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Cognitive Impairment
Predicting Cognition After DBS for Parkinson's Disease 2
The aim of the study is to improve estimation of cognitive outcome after STN-DBS in PD in order to avoid risk factors by optimizing peri- and intraoperative management and personalize therapeutic strategies for optimal long-term…
- Trial name
- NCT06272968
- Testing
- Neuropsychological Testing
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Older Patients, Cognitive Impairment
Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery
Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD).
- Conditions
- Older Patients, Cognitive Impairment, Repetitive Transcranial Magnetic Stimulation, Delayed Neurocognitive Recovery
- Trial name
- NCT06482749
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- 3 sites in China
- Volunteers
- 568 people
- Sponsor
- Peking University First Hospital