Clinical trials: Postmenopausal Bleeding
Postmenopausal Bleeding, Endometrial Cancer
Assessing the Benefit of Pipelle Biopsy in Patients With Postmenopausal Bleeding and an Atrophic-appearing Cavity
Postmenopausal bleeding (PMB) is the occurrence of vaginal bleeding 12 months following a woman's last menstrual cycle. PMB represents one of the most common reasons for referral to gynaecology services.
- Conditions
- Postmenopausal Bleeding, Endometrial Cancer, Endometrial Hyperplasia
- Trial name
- NCT05378152
- Testing
- Pipelle biopsy catheter
- Where
- Ireland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Vaginal Bleeding
Uterine Cavity Assessment and Endometrial Hormonal Receptors in Women With Peri and Post Menopausal Bleeding
100 women with abnormal uterine bleeding (peri and postmenopausal) were subjected to transvaginal ultrasound , saline sonohysterography , Diagnostic hysteroscopy and fractional curettage followed by histopathological examination…
- Trial name
- NCT02385747
- Testing
- hystroscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Uterine Polyp, Uterine Bleeding
Pharmacological Preparation of the Cervix for Hysteroscopy
Pain accompanying office hysteroscopy is the most common reason for its discontinuation. Urogenital atrophy may cause technical difficulties in passage through the cervical canal, further increasing the pain.
- Conditions
- Uterine Polyp, Uterine Bleeding, Endometrium; Senility
- Trial name
- NCT05783479
- Testing
- estradiol, Hyaluronic acid
- Where
- Poland
- Volunteers
- 96 people
- Sponsor
- Jagiellonian University
Postmenopausal Women, Intrauterine Diseases
Office Hysteroscopy in Postmenopausal Women: A Randomized Trial of Cervical Preparation Strategies
The goal of this randomized controlled trial is to evaluate the effectiveness of different cervical preparation strategies before office hysteroscopy in postmenopausal women undergoing evaluation for intrauterine pathology.
- Conditions
- Postmenopausal Women, Intrauterine Diseases, Endometrial Pathology, Postmenopausal Bleeding
- Trial name
- NCT07697781
- Testing
- No Cervical Preparation, Misoprostol ( Cytotec) 200 microgram a tablet, Vaginal Estrogen (7-Day Regimen)
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Faculty of Medicine of Tunis
Postmenopause
Vasomotoric Symptoms Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination
To demonstrate efficacy of continuous combined 0.5 mg estradiol and 2.5 mg dydrogesterone versus placebo in the treatment of vasomotor symptoms after a treatment period of 3 months and to investigate the bleeding pattern over a…
- Trial name
- NCT00251082
- Testing
- continuous combined estradiol and dydrogesterone
- Where
- 18 sites in Croatia, France and 3 more
- Volunteers
- 391 people
- Sponsor
- Solvay Pharmaceuticals
Postmenopausal Bleeding
Hysteroscopic Findings With Histopathologic Report of Endometrium in Patients With Postmenopausal Bleeding
To evaluate hysteroscopic findings in women with postmenopausal bleeding and correlate them with histopathological results of the endometrium., Sohag University Hospital Obstetrics and Gynecology department
- Trial name
- NCT07707570
- Volunteers
- 90 people
- Sponsor
- Sohag University
Postmenopausal Bleeding
Relation Between Human Epididymis Protein 4 (HE4) and Endometrial Pathology in Patients With Postmenopausal Bleeding
All patients included in the study had single or multiple episodes of postmenopausal bleeding with an endometrial thickness of more than 5mm. full history, general and local examination were done.
- Trial name
- NCT03558321
- Testing
- Hysteroscopic guided fractional curretage, total abdominal hysterectomy, bilateral salpingo oophrectomy, with or without pelvic lymph nodal dissection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Endometrial Neoplasms, Postmenopause
HE4 in the Diagnostic Approach of Endometrial Cancer in Patients With Postmenopausal Bleeding
This study aims to explore the sensitivity of an innovative marker, HE4, in the diagnosis approach of endometrial cancer in case of postmenopausal bleedings.
- Conditions
- Endometrial Neoplasms, Postmenopause, Uterine Hemorrhage, Cancer Biomarker
- Trial name
- METRODEC (NCT04867109)
- Testing
- Patients with Post menopausal bleeding, CA125 and HE4 assays
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Endometrial Neoplasms
The Feasibility Study of the Li Brush for the Screening of Endometrial Cancer in the Postmenopausal Period
Investigators aim to collect endometrial sampling with Li Brush among target population who have risks for endometrial neoplasm, then Fractional curettage should performed with these participants, investigators intend to compare…
- Trial name
- NCT02512848
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Arterial Hypertension, Postmenopausal; Menorrhagia
NO3-rich Beet Juice and Exercise on Postmenopausal Women Cardiovascular Health
In the context of physical exercise, there is no evidence of the acute and continued use of beetroot juice with a previously recommended dose of nitrate (NO3) (>300mg) on the cardiovascular performance of hypertensive and…
- Conditions
- Arterial Hypertension, Postmenopausal; Menorrhagia, Cardiovascular Diseases
- Trial name
- NCT05384340
- Testing
- Beetroot juice rich in nitrate
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Postmenopausal Bleeding
Endometrial Evaluation in Cases of Postmenopausal Bleeding
The aim of this prospective observational study is to evaluate abnormal uterine bleeding in postmenopausal women using 3D(dimensional) ultrasound assessment of endometrial volume .Doppler assessment of endometrium and…
- Trial name
- NCT03847415
- Testing
- ultrasound
- Volunteers
- 100 people
- Sponsor
- Cairo University
Postmenopausal Bleeding
Vaginal Dinoprostone Versus Isonicotinic Acid Hydrazide Prior to Diagnostic Office Hysteroscopy
To compare the effectiveness of vaginal dinoprostone and vaginal Isonicotinic acid hydrazide in minimizing the pain experienced by postmenopausal patients during diagnostic office hysteroscopy and to assess the ease of insertion…
- Trial name
- NCT04500496
- Testing
- INH, dinoprostone
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Endometrial Cancer
Evaluation of MCM5 in Postmenopausal Bleeding Patients
The objective of this multi-centre, prospective study, is to evaluate the performance of a urine MCM5 ELISA test (ADXGYNAE) in the detection of endometrial cancer in patients with postmenopausal bleeding.
- Trial name
- NCT05287048
- Testing
- MCM5 ELISA
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Arquer Diagnostics Ltd
Postmenopausal Bleeding
A Review on the Outcome of Patient Managed in Postmenopausal Bleeding Clinic
Postmenopausal bleeding (PMB) is a common gynaecological complaint, accounting for up to 5 to 10 % of postmenopausal women being referred to gynaecological outpatient clinic.
- Trial name
- NCT03382145
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 17,956 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Postmenopausal Bleeding, Endometrial Cancer
Performance of Ultrasound in Women With Postmenopausal or Abnormal Uterine Bleeding Between White and Black Ethnic Groups- a Retrospective Cohort Study.
Primary Objective: To assess whether there is a higher incidence of uninformative ultrasound in black vs white women
- Trial name
- NCT06293066
- Testing
- Ultrasound
- Where
- United Kingdom
- Volunteers
- 330 people
- Sponsor
- King's College Hospital NHS Trust
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Pipelle Versus Karman Endometrial Biopsy Under Standardized Paracervical Block
Endometrial biopsy is a commonly used outpatient procedure to evaluate abnormal uterine bleeding and postmenopausal bleeding. Different sampling methods are available, but their diagnostic adequacy and patient experience may…
- Trial name
- PB-EMB (NCT07366814)
- Testing
- Pipelle Endometrial Biopsy, Karman Cannula Endometrial Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 480 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Post-Menopausal Bleeding, Post-Menopausal Endometrial Thickness
Evaluation of a New Hysteroscopic Grasper for Endometrial Biopsy in Post-menopausal Patients
Hysteroscopic endometrial biopsy is usually performed through the classic spoon grasper. Recently, a new hysteroscopic grasper with knurled terminal end and cutting jaws was designed, in order to improve feasibility of the…
- Trial name
- NCT03427957
- Testing
- Endometrial biopsy with the new hysteroscopic grasper with knurled terminal end and cutting jaws, Endometrial biopsy with the hysteroscopic spoon grasper, Endometrial biopsy with the hysteroscopic alligator grasper
- Where
- 2 sites in Italy
- Volunteers
- 75 people
- Sponsor
- Università degli Studi dell'Insubria
Postmenopausal; Menorrhagia, Physical Inactivity
Effects of Dietary Nitrate Intake on Physical Performance of Middle-aged Women
Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 15 physically inactive hypertensive women will participate a 8-day trial, each with two intervention protocols: 1) placebo and 2) beetroot; in…
- Conditions
- Postmenopausal; Menorrhagia, Physical Inactivity, Motor Activity
- Trial name
- NCT05820321
- Testing
- Beetroot juice rich in nitrate, Beetroot juice NO3 depleted
- Where
- 2 sites in Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo
Abnormal Uterine Bleeding, Menorrhagia; Postmenopausal
Therapeutic Effect of Herbal Infusion on Menometrorrhagia
This is an interventional, non-randomized, controlled, pilot study that explores a new approach to treat, Abnormal uterine bleeding-menometrorrhagia in women, being candidates for hysterectomy, based on tea infusion consumption…
- Conditions
- Abnormal Uterine Bleeding, Menorrhagia; Postmenopausal, Metrorrhagia, Hysterectomy
- Trial name
- HERBALTREAT (NCT05406960)
- Testing
- Tea infusion
- Where
- Tunisia
- Volunteers
- 13 people
- Sponsor
- Faculty of Medicine, Sousse
Menopause, Postmenopausal Bleeding
Observational Study to Investigate the Occurrence of Bleeding in Postmenopausal Women Treated With Estradiol/NETA for 12 Months
This study is conducted in Europe. The primary aim of this observational study is to investigate the occurrence of bleeding in women taking 0.5 mg estradiol and 0.1 mg norethisterone acetate (NETA) for 12 months.
- Trial name
- NCT01076621
- Testing
- 0.5 mg estradiol / 0.1 mg norethisterone acetate (NETA)
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 176 people
- Sponsor
- Novo Nordisk A/S