Clinical trials: Posterior Urethral Valve
Posterior Urethral Valve
Efficacy and Safety of Mirabegron Versus Oxybutynin After Posterior Urethral Valve Ablation
Posterior urethral valve is the main cause of bladder outlet obstruction in male infants and the most common cause of obstructive uropathy leading to chronic renal failure and end-stage renal disease in children.The incidence of…
- Trial name
- NCT07668232
- Testing
- Mirabegron
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- South Valley University
Male Urogenital Diseases
Early Oxybutinin Treatment for Boys With Posterior Urethral Valves
Boys with posterior urethral valves have bladder dysfunction of varying severity. Early treatment of these children with anticholinergics is recommended by some teams, although there have never been any clear studies on the…
- Trial name
- PRETIPUV (NCT04526353)
- Testing
- Oxybutynin 1 mg/ml Syrup
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Posterior Urethral Valves
CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral Valves
Children with posterior urethral valves (PUV) are at risk of presenting febrile urinary tract infections (UTI). Circumcision has been shown to decrease the number of febrile UTIs in healthy children.
- Trial name
- CIRCUP (NCT01537601)
- Testing
- Circumcision, Antibiotic prophylaxis alone
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Chronic Kidney Diseases, Bladder Dysfunction
Concomitant Renal and Urinary Bladder Allograft Transplantation
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
- Conditions
- Chronic Kidney Diseases, Bladder Dysfunction, Bladder Absence, Posterior Urethral Valve
- Trial name
- NCT04626167
- Testing
- Concomitant Renal and Urinary Bladder Allograft Transplantation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Posterior Urethral Valve
Efficacy and Safety of Tamsulosin for Children with Posterior Urethral Valve.
To determine whether there is a role for Tamsulosin, A Selective Alpha-1 Adrenergic Blocker, as therapy in children with Posterior Urethral Valve post valve ablation , and whether there are side effects involved.
- Trial name
- NCT06737016
- Testing
- Tamsulosin, Oxybutynin, Trimethoprim/sulfamethoxazole (TMP/SMZ)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Quality of Life, Posterior Urethral Valve
Study of the Quality of Life in School Aged-children With Posterior Urethral Valves
Posterior urethral valves (PUV) are the most common congenital obstructive lesion of the urethra, affecting from 1 per 3000 to 1 per 8000 live births.
- Conditions
- Quality of Life, Posterior Urethral Valve, Renal Insufficiency, Chronic Renal Disease
- Trial name
- QUALIVUP (NCT06439862)
- Testing
- Children with PUV
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Posterior Urethral Valve
Outcomes of Posterior Urethral Valve Fulguration
To evaluate the long-term outcome after fulguration of the posterior urethral valve.
- Trial name
- NCT06867263
- Testing
- Fulguration
- Volunteers
- 35 people
- Sponsor
- Assiut University
Urethral Obstruction
Standardized Prenatal Clinical Care for LUTO
The investigators propose a standardized prenatal management, based on the scientific evidence published in the literature, to manage prenatally fetuses with lower urinary tract obstruction (LUTO).
- Trial name
- NCT02315521
- Testing
- Fetal Intervention for LUTO
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Urethral Obstruction
Fetal Cystoscopy for Lower Urinary Tract Obstruction
This is a pilot study to evaluate the safety, feasibility, and effectiveness of fetal cystoscopy as an experimental procedure in avoiding perinatal death and renal impairment and to compare to the investigators clinical…
- Trial name
- NCT02446184
- Testing
- Fetal Cystoscopy, Fetal vesicoamniotic shunt
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Baylor College of Medicine
Lower Urinary Tract Obstructive Syndrome
Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions
There are two options of fetal treatment in cases of severe lower urinary tract obstructions: the vesico-amniotic shunting and fetal cystoscopy.
- Trial name
- CYSTUO (NCT01552824)
- Testing
- CYSTO, Vesico-amniotic shunt
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Posterior Urethral Valve
Overnight Bladder Drainage and Posterior Urethral Valve Sequelae
We hypothesize that overnight catheter drainage (OCD) of the urinary bladder might improve bladder dynamics and subsequently lead to improvement or resolution of hydronephrosis (HN) and renal function in boys who underwent PUV…
- Trial name
- NCT05168358
- Testing
- Overnight Bladder Drainage
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Mansoura University
Posterior Urethral Valves
Validation of a Fetal Urine Peptidome-based Classifier to Predict Post-natal Renal Function in Posterior Urethral Valves
Validate the use of fetal urine peptidome-analysis and explore amniotic fluid markers for the stratification of fetuses with Posterior Urethral Valve for post-natal renal function.
- Trial name
- Antenatal (NCT03116217)
- Where
- 29 sites in Belgium, France and 7 more
- Volunteers
- 400 people
- Sponsor
- University Hospital, Toulouse
Pediatric Disorder, Hydronephrosis in Children
Effect of Concomitant Bladder Neck Incision and Urethral Valve Ablation on Surgical Re-intervention Rate for Patients With Posterior Urethral Valve
To determine the short-term effects of concurrent valve ablation and bladder neck incision on re-intervention rate for patients with posterior urethral valve.
- Conditions
- Pediatric Disorder, Hydronephrosis in Children, Hydronephrosis, Secondary, Hydronephrosis Congenital
- Trial name
- NCT05087537
- Testing
- Valve ablation, Valve ablation and bladder neck incision
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Mansoura University
Posterior Urethral Valves
Efficacy and Safety of Circumcision Alone on Risk of Febrile Urinary Tract Infections in Boys With Posterior Urethral Valves: a Prospective Randomized Open-label Multicentric Trial Enriched With Historic Controls.
Boys with posterior urethral valves (PUV) are at increased risk of developing febrile urinary tract infections (fUTIs). As shown in the CIRCUP trial, circumcision plus antibiotic prophylaxis reduces the risk of FUTIs compared…
- Trial name
- CIRCUP 2 (NCT07527442)
- Testing
- Antibiotics strategy, Circumcision
- Where
- 13 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux