Clinical trials: Postcholecystectomy Syndrome
Post Operative Pain
Pre-incision Versus Lapaorscopic-assisted Transversus Abdominis Plane (TAP) and Rectus Sheath Block for Post-Cholecystectomy Pain
The goal of this clinical trial is to compare pre-incision vs laparoscopic assisted Transversus abdominis plane and rectus sheath block in patients undergoing laparoscopic cholecystectomy.
- Trial name
- NCT05856682
- Testing
- Laparoscopic-assisted TAP block(LATAP) and Rectus Sheath block
- Where
- Pakistan
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Patel Hospital, Pakistan
Laparocele
Post-Cholecystectomy Gall Bladder Remnant and Cystic Duct Stump Stone
Introduction: cholecystectomy relieves pre-surgical symptoms of gallbladder disease. The persistence of symptoms was recorded in 10 - 20% of cases. Residual gall bladder/cystic duct stump stone is one of the most important cause.
- Trial name
- NCT04329143
- Testing
- open completion cholecystectomy, lap completion cholecystectomy
- Volunteers
- 2 people
- Sponsor
- Zagazig University
Irritable Bowel Syndrome, Gallstone Disease
Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.
This study aims to evaluate pharmacokinetic profile, safety and establish bioequivalence of the investigational drug Trimedat® 76,95 mg orally disintegrating tablets compared to the reference drug Trimedat® 100 mg tablets in…
- Conditions
- Irritable Bowel Syndrome, Gallstone Disease, GERD, Biliary Dyskinesia
- Trial name
- NCT07421011
- Testing
- Trimedat®
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Common Bile Duct Injury
Post-cholecystectomy Major Bile Duct Injury
Bile duct injury (BDI) is one of the devastating recognized complications of cholecystectomy which does not respect the seniority or experience of the surgeon.
- Trial name
- NCT05436626
- Testing
- Early BDI reconstruction without abdominal sepsis control, Early BDI reconstruction with abdominal sepsis control, Delayed reconstruction
- Volunteers
- 277 people
- Sponsor
- South Valley University
Cholelithiasis, Cholecystectomy, Laparoscopic
Unilateral Laparoscopic TAP Block vs. Local Infiltration in Post-Cholecystectomy Analgesia
This study compared different methods of pain control after laparoscopic gallbladder removal. A total of 160 patients were randomly assigned to receive either a unilateral laparoscopic TAP block, local anesthetic infiltration, a…
- Conditions
- Cholelithiasis, Cholecystectomy, Laparoscopic, Pain, Postoperative, Anesthesia, Local
- Trial name
- TAP vs LAI (NCT07176299)
- Testing
- Unilateral laparoscopic TAP block (0.25% bupivacaine), Local anesthetic infiltration (0.25% bupivacaine), Combined TAP block and local anesthetic infiltration (0.25% bupivacaine)
- Where
- Poland
- Volunteers
- 160 people
- Sponsor
- University of Warmia and Mazury in Olsztyn
Postcholecystectomy Syndrome
Comparison of Two Kinds of Biliary Intestinal Reconstruction in Cholangiectasia
To observe and compare the short-term and long-term effects of different biliary and intestinal reconstruction methods for the treatment of congenital cystic dilatation of bile duct .
- Trial name
- NCT03401424
- Testing
- improved Warren-type style, Roux-en-Y style
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Southwest Hospital, China
Gallstone
Post-Cholecystectomy Quality of Life
The study aims to identify factors associated with no increase in gastrointestinal quality of life after elective cholecystectomy for gallstones.
- Trial name
- NCT03326154
- Testing
- No intervention, observational
- Where
- 2 sites in Finland
- Volunteers
- 1,000 people
- Sponsor
- Helsinki University Central Hospital
Post-cholecystectomy Gastrointestinal Spasms
Effectiveness of Duspatalin® in Patients With Post-cholecystectomy Gastrointestinal Spasm
Prospective, multicenter, non-comparative, observational program designed to assess the effectiveness of a 2-6 weeks treatment with Duspatalin® 200mg bis in die = twice a day (BID) and changes in quality of life in patients with…
- Trial name
- ODYSSEY (NCT02260154)
- Testing
- Mebeverine
- Where
- 21 sites in Russia
- Volunteers
- 220 people
- Sponsor
- Abbott
Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)-Post-cholecystectomy Metabolic Changes -Hepatic Steatosis
Fatty Liver in Long Standing Cholecystectomy
This observational study aims to evaluate the association between long-term cholecystectomy and the development of metabolic dysfunction-associated fatty liver disease (MAFLD) in adult patients.
- Trial name
- MAFLD-Chole St (NCT07284004)
- Volunteers
- 100 people
- Sponsor
- Yasmeen Ahmed Farrag Ahmed
Gallstone Disease, Gallstone; Colic
A Randomized Controlled Trial Comparing Fat-free Versus Balanced (WHO) Diet in Gallstone Disease
The goal of this trial is to assess the effect on the quality of life (QoL) of recommending a fat-free diet versus a balanced WHO diet in symptomatic patients with gallstones and in patients undergoing cholecystectomy for…
- Conditions
- Gallstone Disease, Gallstone; Colic, Gallstone; Cholecystitis, Acute, Cholelithiases
- Trial name
- RADIGAL (NCT06405906)
- Testing
- Fat-free diet, Balanced WHO diet
- Where
- Greece
- Volunteers
- 242 people
- Sponsor
- University Hospital of Crete
Laparoscopic Cholecystectomy
Quadratus Lumborum Block vs Transversus Abdominis Plane Block for Post-cholecystectomy Analgesia
In laparoscopic cholecystectomy, overall pain is a conglomerate of three different and clinically separate components: incisional pain (somatic pain) due to trocar insertion sites, visceral pain (deep intra abdominal pain), and…
- Trial name
- NCT03323684
- Testing
- Quadratus lumborum block Group (QL), Transversus abdominis plane Group (TAP), Control group (C)
- Where
- 2 sites in Egypt
- Volunteers
- 159 people
- Sponsor
- Mansoura University
Laparoscopic Cholecystectomy, Pain
A Randomized, Double-Blind Study of the Efficacy and Safety of Valdecoxib Compared to Placebo for Treatment of Post- Cholecystectomy Surgery Pain
To evaluate the analgesic efficacy, general safety, and effects on health outcome measures and opioid-related symptoms of 2 valdecoxib dosing regimens compared with placebo in patients with moderate or severe pain following…
- Trial name
- NCT00661635
- Testing
- valdecoxib
- Where
- 65 sites in United States
- Volunteers
- 490 people
- Sponsor
- Pfizer
Laparoscopic Cholecystectomy Surgery
Esmolol Versus Sufentanil on the Quality of Post-cholecystectomy Recovery Laparoscopic Anaesthesia With Orotracheal Intubation on an Outpatient Basis
There are 120,000 outpatient laparoscopic cholecystectomies with orotracheal intubation per year in France. Sufentanil is the most commonly used morphine during surgery in France, but morphines have harmful effects when…
- Trial name
- ESA (NCT07019818)
- Testing
- Esmolol Hcl 10Mg/Ml Inj, Sufentanil 5 mcg
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Limoges
Bile Duct Injury
Laparoscopic Versus Open Surgical Management of Post Cholecystectomy Bile Duct Injury
Comparison between laparoscopic and open surgical management of post cholecystectomy bile duct injury.
- Trial name
- NCT05243225
- Testing
- Laparoscopic versus open surgical management of post cholecystectomy bile duct injury
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postcholecystectomy Syndrome
Effect of Rowachol on Prevention of Postcholecystectomy Syndrome
Postcholecystectomy syndrome (PCS) includes a heterogeneous group of diseases, usually manifested by the presence of abdominal symptoms following gallbladder removal.
- Trial name
- NCT01765465
- Testing
- Rowachol
- Where
- 2 sites in South Korea
- Volunteers
- 138 people
- Sponsor
- DongGuk University
Biliary Fistula
Early Versus Late Intervention After Biliary Tract Injury Post Cholecystectomy
Bile duct injury following cholecystectomy is an iatrogenic catastrophe associated with significant peri operative morbidity and mortality(1, 2) reduced long term survival(3) and quality of life(4, 5) and high rates of subsequent…
- Trial name
- NCT04134546
- Testing
- CBD exoloration
- Volunteers
- 30 people
- Sponsor
- Assiut University
Sphincter of Oddi Dysfunction
Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction
Sphincter of Oddi dysfunction (SOD) refers to biliary kinetic abnormality of the sphincter of Oddi (SO), often accompanied by pain, hepatic and pancreatic enzyme elevation, common bile duct (CBD) dilation or onset of…
- Trial name
- NCT02833103
- Testing
- Danshu Capsules, Pinaverium Bromide
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine