Clinical trials: Post-stroke Depression
Ischemic Stroke
Effect of a Semiotically-Optimized Video Education Model on Post-Stroke Rehabilitation
Stroke is a leading cause of death and disability worldwide. Many stroke survivors face difficulties with daily activities, sleep problems, anxiety, and depression during recovery.
- Trial name
- SOVE-Stroke (NCT07709806)
- Testing
- Semiotically-Optimized Video Education, Standard Video Education
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiamen University
Stroke
Predicting Cognitive Development in Younger Stroke Patients Using the Oxford Cognitive Screen
The purpose of this study is to investigate whether Oxford Cognitive Screen (OCS) can be used as a predictive tool during hospital admission in younger (<65 years) stroke patients, i.e.
- Trial name
- STROKY (NCT05612815)
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Bispebjerg Hospital
Stroke, Depression
The Sunlight Exposure Therapy on the Improvement of Depression and Quality of Life in Post-stroke Patients
Chronic diseases has been the leading causes of death in 2015 to 2017 based on the National database. In particular, cerebrovascular disease was the third in 2015, the fourth in 2016 and 2017.
- Trial name
- NCT04036565
- Testing
- sunlight therapy
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Stroke
Secondary Prevention and Health Promotion After Stroke
The aim of this study was to examine to what extent a one year population of stroke patients at a university hospital had well regulated risk factors and health problems one year after stroke, and if a structured nurse-led…
- Trial name
- NCT01466907
- Testing
- Secondary prevention, supportive counselling, Standard care until one year follow-up
- Where
- Sweden
- Volunteers
- 597 people
- Sponsor
- Skane University Hospital
Acute Ischemic Stroke
The Association of Gut Microbes and Their Metabolites With Post-stroke Depression
In this study, the clinical data of patients with AIS were collected, 16s RNA was used to detect the composition and diversity of intestinal flora, and flow cytometry and mass spectrometry were used to detect intestinal…
- Trial name
- NCT05414227
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Vascular Cognitive Impairment, Post-stroke Depression
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Stroke is a leading cause of disability, affecting about 34,000 to 41,000 individuals in the Netherlands of middle and old age every year.
- Conditions
- Vascular Cognitive Impairment, Post-stroke Depression, Post-stroke Apathy, Post-stroke Dementia
- Trial name
- CASPER (NCT02585349)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Maastricht University Medical Center
Stroke, Depression
Poststroke Depression of Clinical Trial Registration
The investigators aim to explore the relationship between gut microbiota composition and earlier poststroke depression via 16S rRNA sequencing.
- Trial name
- IFEPSDAIS (NCT03863951)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Stroke, Post-stroke Depression
Efficacy of Repeated Transcranial Magnetic Stimulation Based on Near-infrared Imaging in Patients With Post-stroke Depression
This is a randomized controlled trial to evaluate the efficacy and safety of Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) in post-stroke depression (PSD), explore mechanism of rTMS with Functional…
- Trial name
- PSD fNIRS rTMS (NCT06723769)
- Testing
- rTMS treatment, conventional treatment
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Dingqun Bai
Post-stroke Depression
Efficacy of Accelerated Repetitive Transcranial Magnetic Stimulation on Patients With Post-stroke Depression
The FDA approved repetitive transcranial magnetic stimulation (rTMS) for patients with Major Depressive Disorder (MDD) in 2008. The conventional rTMS protocol that has been used effectively for major depression is 5 days per week…
- Trial name
- NCT06157333
- Testing
- The Magstim Rapid2 Plus Magnetic Stimulator (Magstim, Whitland, Dyfed, UK)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara City Hospital Bilkent
Post-stroke Depression
Affective Touching on Poststroke Depression
This mixed-method study includes a randomised controlled trial and an exploratory qualitative study, and aims to examine the effects of caregiver-delivered affective touch on depressive symptoms, state of attachment security…
- Trial name
- NCT03789994
- Testing
- Affective touch, Fine motor exercise
- Where
- China
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stroke, Depressive Symptoms
Instant Message-delivered Brief Internet-based Cognitive Behavioural Therapy (iCBT) for Post-stroke Depression
Around one third of stroke survivors develop depression at any point of time following the stroke event. Post-stroke depression (PSD) is associated with negative care outcomes including poorer function, longer hospital stays…
- Conditions
- Stroke, Depressive Symptoms, Mobile Phone Use
- Trial name
- NCT05892965
- Testing
- iCBT-based EMI
- Where
- 7 sites in Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Apathy, Stroke
Accelerated rTMS vs. Sham for Stroke Apathy
Apathy is a common set of symptoms seen in many people following a stroke. Apathy occurs when a person has lost motivation, becomes withdrawn, and stops doing things that used to be important to them.
- Conditions
- Apathy, Stroke, Stroke Sequelae, Stroke/Brain Attack
- Trial name
- NCT07113067
- Testing
- MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Active), Brainsight Neuronavigation System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Cerebrovascular Stroke, Depression
Living Well With Stroke
The overall goal of this study is to conduct a three-armed randomized controlled trial (RCT) in stroke survivors with depression to determine if a brief psychosocial-behavioral therapy intervention delivered in-person (arm A) or…
- Trial name
- PSD2 (NCT01133106)
- Testing
- Brief pleasurable events/behavioral therapy, Standard care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Cerebrovascular Accident, Depression
Sertraline for Preventing Post-stroke Depression and Improving Rehabilitation Outcomes
This study will determine the effectiveness of sertraline administration after a stroke in preventing the onset of post-stroke depression.
- Trial name
- NCT00177424
- Testing
- sertraline
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- University of Pittsburgh
Post-stroke Depression
rTMS as an add-on Therapy in Patients With Post-stroke Depression
About 50% of all stroke patients develop post-stroke depression (PSD). A meta-analysis has shown that rTMS treatment can reduce depressive symptoms in PSD patients.
- Trial name
- NCT03761303
- Testing
- active rTMS
- Where
- Germany
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Post-stroke Depression
Integrated Rehabilitation in Treating Post-stroke Depression
Post-stroke depression (PSD) is a common complication of stroke that leads to dysfunction and reduces the quality of life. PSD exacerbates cognitive dysfunction, delays the recovery process, and increases the disability…
- Trial name
- IRTPD (NCT05187975)
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 202 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Stroke
Post Stroke Psychological Distress
Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.
- Trial name
- POSTPSYDIS (NCT01187342)
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- Charite University, Berlin, Germany
Post Stroke Depression
Allopregnanolone (Zuranolone) in Post-stroke Depression
The goal of this Phase II clinical trial is to learn if the oral synthetic allopreganolone analog (zuranolone) is safe to take and is well tolerated by stroke survivors experiencing moderate to severe post-stroke depression and…
- Trial name
- ALLO in PSD (NCT06759558)
- Testing
- Zuranolone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Stroke, Depression
Internet-based CBT After Stroke Pilot
Mood disorders occur in 25-30% of stroke patients and are associated with lower quality of life, higher mortality, increased healthcare utilization, and higher costs.
- Trial name
- iSAD (NCT03615079)
- Testing
- Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Pennsylvania