Clinical trials: Post-Traumatic Stress
PTSD, Cannabis Use
Effect of Extended Cannabis Abstinence on PTSD Symptoms
This will be a 12-week randomized trial. Outpatients and patients from the Mood and Anxiety program at the Centre for Addiction and Mental Health (CAMH) with a current diagnosis of post-traumatic stressed disorder (PTSD) and…
- Conditions
- PTSD, Cannabis Use, Cognitive Symptom, Comorbidities and Coexisting Conditions
- Trial name
- CANPOST (NCT05162651)
- Testing
- Contingency-management, Enhanced usual care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre for Addiction and Mental Health
Stress Disorders, Post-Traumatic
Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder
This study effects the effects of transcutaneous cervical vagal nerve stimulation (tcVNS) or a sham control on brain, physiology, and PTSD symptoms in Veterans with posttraumatic stress disorder (PTSD).
- Trial name
- VNS in PTSD (NCT05517304)
- Testing
- tcVNS
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- VA Office of Research and Development
Major Depression
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S.
- Trial name
- PIVOT (NCT07226232)
- Testing
- Psilocybin
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
PTSD - Post Traumatic Stress Disorder, PTSD
Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
The Redefine Study (COMP202) is testing COMP360 to see if it may reduce post-traumatic stress disorder (PTSD) symptoms when administered alongside monitoring and support from a trained study team.
- Conditions
- PTSD - Post Traumatic Stress Disorder, PTSD, PTSD Symptoms, PTSD, Post Traumatic Stress Disorder
- Trial name
- Redefine (NCT07570654)
- Testing
- COMP360 psilocybin
- Where
- 10 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- COMPASS Pathways
Posttraumatic Stress Disorder (PTSD)
Trauma Suppression Training for Veterans
Intrusive memories of trauma are a core and often persistent symptom of posttraumatic stress disorder (PTSD). This study tested whether veterans with PTSD could take part in a computer-based training program that teaches people…
- Trial name
- TSTV (NCT07891559)
- Testing
- Web-based Think/No-Think retrieval-suppression training
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Palo Alto Veterans Institute for Research
Acute Stress Reaction, Acute Stress Disorder
Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL)
This study will examine the safety and efficacy of TNX-102 SL to reduce ASR symptoms and behavioral changes among patients presenting to the emergency department (ED) after motor vehicle collision (MVC).
- Conditions
- Acute Stress Reaction, Acute Stress Disorder, Neurocognitive Function, Post-traumatic Stress
- Trial name
- OASIS (NCT06636786)
- Testing
- Cyclobenzaprine HCl
- Where
- 9 sites in United States
- Volunteers
- 180 people
- Sponsor
- University of North Carolina, Chapel Hill
Insomnia, Depression - Major Depressive Disorder
Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI)
The goal of this pilot clinical trial is to evaluate the effectiveness and delivery method of a CBTI self-managed digital mobile application in service members. The main questions it aims to answer are: RQ1.
- Conditions
- Insomnia, Depression - Major Depressive Disorder, PTSD
- Trial name
- NCT07335276
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Volunteers
- 144 people
- Sponsor
- Madigan Army Medical Center
Traumatic Brain Injuries, TBI (Traumatic Brain Injury)
Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI.
- Conditions
- Traumatic Brain Injuries, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- ReVIVE (NCT07890337)
- Testing
- Virtual Reality, Standard Psychotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Stress Disorders, Post-Traumatic, Mental Disorders
Group-based Stabilization and Skill Training for Patients With Lasting Posttraumatic Reactions in Mental Health Care
This study evaluates the addition of a group based stabilization and skill-training intervention to individual out-patient treatment for long lasting post-traumatic reactions.
- Conditions
- Stress Disorders, Post-Traumatic, Mental Disorders, Trauma and Stressor Related Disorders
- Trial name
- NCT03887559
- Testing
- Group-based stabilization and skill training in addition to individual treatment, Treatment as usual
- Where
- Norway
- Volunteers
- 160 people
- Sponsor
- St. Olavs Hospital
Stress Disorders, Post-Traumatic, Aggression
Manage Emotions to Reduce Aggression (MERA)
Post-traumatic stress disorder (PTSD) is one of the most prevalent mental health conditions affecting Veterans who have served since 9/11. Veterans with PTSD report difficulty controlling impulsive aggression (IA).
- Conditions
- Stress Disorders, Post-Traumatic, Aggression, Emotion Regulation
- Trial name
- MERA (NCT04793776)
- Testing
- Manage Emotions to Reduce Aggression, Present Centered Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 233 people
- Sponsor
- VA Office of Research and Development
PTSD
Exercise and Emotional Learning in Posttraumatic Stress Disorder
The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions.
- Trial name
- NCT06127342
- Testing
- Moderate Intensity Exercise, Low Intensity Exercise
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Christal L Badour
PTSD, Suicidal Thoughts and Behaviors
Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study
This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD.
- Conditions
- PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
- Trial name
- CNS (NCT07222306)
- Testing
- 1-(2-[+F]fluoroethyl)-L-tryptophan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Stress Disorders, Post-Traumatic
Salience Network Informed rTMS for PTSD
The proposed study will test whether magnetic resonance imaging (MRI)-guided transcranial magnetic stimulation (TMS) can reduce posttraumatic stress disorder (PTSD) symptoms in Veterans.
- Trial name
- NCT07886840
- Testing
- Active MRI-Guided intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- VA Office of Research and Development
Moral Distress, Moral Injury
Coping and Adaptation for Recovery From Moral Injury: A Group Intervention for Clinical Psychology Residents
Moral distress may arise when health care professionals are unable to act in accordance with their professional values or believe that they have participated in, witnessed, or been unable to prevent situations that conflict with…
- Trial name
- CARE-MI (NCT07887581)
- Testing
- CARE-MI Group Intervention
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Delirium, Critical Illness
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs.
- Conditions
- Delirium, Critical Illness, Sedation Complication, Executive Dysfunction
- Trial name
- mini-MENDS (NCT04801589)
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center
Moral Injury, TEPT
A Comprehensive Group Intervention for Psychosocial Personnel at Risk of Stress and Moral Injury
The objective of this randomized controlled trial is to evaluate the effectiveness of the CARE-MI group intervention in reducing symptoms of post-traumatic stress and moral injury in support staff working with individuals…
- Trial name
- CARE-MI-PsychS (NCT07140263)
- Testing
- CARE MI, TAU: Treatment as usual
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Post Traumatic Stress Disorder, Obstructive Sleep Apnea
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Conditions
- Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
- Trial name
- NCT05156112
- Testing
- Positive Airway Pressure Device
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
Safety, Psychological, Acceptability of Health Care
Body-oriented Psychotherapy for Individuals With a History of Child Maltreatment and Trauma-related Symptoms
This Pilot Randomized Controlled Trial (RCT) overall aim is to establish the safety, feasibility, acceptability and preliminary effects of a body-oriented psychotherapy, Somatic Experiencing (SE), on social functioning and mental…
- Conditions
- Safety, Psychological, Acceptability of Health Care, Psychological Safety, Maltreatment, Child
- Trial name
- NCT06549777
- Testing
- SE-group, Control
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Monique Pfaltz
Post-Traumatic Stress Disorder, PTSD
Software as a Medical Device for the Treatment of Patients With PTSD
To evaluate the efficacy and safety of Software as a Medical Device in patients with Post-Traumatic Stress Disorder (PTSD)
- Trial name
- NCT06589505
- Testing
- Software as a Medical Device
- Where
- 35 sites in Japan
- Volunteers
- 52 people
- Sponsor
- Otsuka Medical Devices Co., Ltd. Japan
Post Traumatic Stress Disorder, Depression - Major Depressive Disorder
Mindfulness-based Psilocybin Therapy for PTSD
The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD).
- Trial name
- NCT07104916
- Testing
- Psilocybin + MBCT therapy, Active Comparator: Psilocybin with Support Only
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anthony P King