Clinical trials: Post-Hepatectomy Liver Failure
Liver Failure
Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test
The purpose of this study is to investigate safety and efficacy of intravenously injected 0.4% 13-C-Methacetin solution for the determination of liver function with the LiMAx-test on patients with partial liver resection.
- Trial name
- NCT01785082
- Testing
- 13-C-Methacetin
- Where
- 4 sites in Germany
- Volunteers
- 149 people
- Sponsor
- Humedics GmbH
Liver Failure as A Complication of Care
Early Liver Support With MARS in Post-hepatectomy Liver Failure
This is a prospective, randomized, open-label, multicentre study involving European centers with experience in the management of PHLF to assess the impact of early liver support with MARS on survival in patients with…
- Trial name
- ELISH (NCT03761238)
- Testing
- Molecular Adsorbent Recirculating System, Standard medical treatment (SMT)
- Volunteers
- 44 people
- Sponsor
- Stefan Gilg, MD, PhD
Post-hepatectomy Liver Failure, Hepatocellular Carcinoma
Usability and Clinical Effectiveness of an Interpretable Deep Learning Framework for Post-Hepatectomy Liver Failure Prediction
The goal of this in-silico clinical trial is to learn about the usability and clinical effectiveness of an interpretable deep learning framework (VAE-MLP) using counterfactual explanations and layerwise relevance propagation for…
- Conditions
- Post-hepatectomy Liver Failure, Hepatocellular Carcinoma, Artificial Intelligence
- Trial name
- NCT06031818
- Testing
- The explanation of deep learning framework (VAE-MLP) , including counterfactual explanations and layerwise relevance propagation, The model prediction, The model prediction and the explanation of deep learning framework (VAE-MLP) , including counterfactual explanations and layerwise relevance propagation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Maastricht University
Post Hepatectomy Liver Failure
Early Postoperative Extracorporal Liver Support Therapy (ELS) as a Tool to Manage Post Hepatectomy Liver Failure (PLF)
Early postoperative extracorporal liver support therapy (ELS) as a tool to manage post hepatectomy liver failure (PLF). Post-operative liver failure (PLF) has been identified as a major risk factor leading to increased morbidity…
- Trial name
- NCT03011424
- Testing
- Extracorporeal liver support therapy (ELS)
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska University Hospital
Liver Cancer, Liver Metastases
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
The DRAGON registry aims to collect data on combined portal and hepatic vein embolization (PVE/HVE) for liver tumors, a technique expected to enhance liver regeneration compared to standard PVE.
- Trial name
- NCT07717437
- Where
- 31 sites in United States, Australia and 11 more
- Volunteers
- 350 people
- Sponsor
- Maastricht University Medical Center
Post-Hepatectomy Liver Failure, Liver Failure
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the…
- Conditions
- Post-Hepatectomy Liver Failure, Liver Failure, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- BEYOND-SIZE (NCT07727759)
- Testing
- Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
- Where
- 3 sites in Egypt
- Volunteers
- 1,070 people
- Sponsor
- Minia University
Acute Renal Failure
Development and Validation of an Enhanced Prediction Score for Postoperative Acute Renal Failure After Liver Resection
Post-operative acute renal failure is a severe post-operative complication and is associated with high mortality. The enhanced prediction score, including pre-as well as intra-operative predictors accurately predicted ARF…
- Trial name
- NCT01318798
- Where
- Switzerland
- Volunteers
- 549 people
- Sponsor
- University of Zurich
Hepatic Insufficiency, Liver Failure
Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection
The goal of the study is to determine whether intravenous glucose administration before liver resection preserves hepatic glycogen resulting in improved hepatic metabolic function after the operation.
- Trial name
- NCT00623662
- Testing
- Preoperative glucose infusion, Preoperative normal saline infusion
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Post-hepatectomy Liver Failure
Evaluating the Association Between Sphingolipid Metabolites and Post-hepatectomy Liver Failure
Hepatectomy is an essential treatment for various benign and malignant diseases of the liver. However, post-hepatectomy liver failure (PHLF) is still a life-threatening complication after hepatectomy.
- Trial name
- NCT03598465
- Where
- 3 sites in China
- Volunteers
- 591 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Liver Failure, Liver Transplant; Complications
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors
Because of the insufficiency of cadaveric organs and increasing need for organs, the interest in living donor liver transplantation have been greatly increased.
- Conditions
- Liver Failure, Liver Transplant; Complications, Post Operative Pain
- Trial name
- NCT05441150
- Testing
- Low dose ketamine infusion, 0.9% NaCl infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inonu University
Terlipressin Adverse Reaction, Ascites Hepatic
The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy
Portal vein hypertension is associated with post-hepatectomy liver failure in patients with liver cirrhosis. Our previous study found that bolus injection of 1 mg terlipressin immediately after hepatectomy decreased portal vein…
- Conditions
- Terlipressin Adverse Reaction, Ascites Hepatic, Liver Failure, Acute Kidney Injury
- Trial name
- NCT04221672
- Testing
- Terlipressin plus standard care, Standard care
- Where
- 4 sites in China
- Volunteers
- 86 people
- Sponsor
- Shanghai Zhongshan Hospital
Liver Failure
The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF)
Post hepatectomy liver failure (PHLF) is a serious medical problem could lead to patient death, however, definite treatment strategy has not been established.
- Trial name
- NCT02882347
- Testing
- Somatostatin
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Korea University Anam Hospital
Liver Failure, Major Hepatectomy
Pneumatic Reversible Portal Vein Diameter Modulation After Major Hepatectomy
This ring aimed to preserve an intra-hepatic porto-caval gradient inferior to 5 mm Hg during and after major hepatectomy (48h) to protect the liver during the initial phases of liver regeneration.
- Trial name
- MODHEP1 (NCT02390713)
- Testing
- MID-AVR
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Failure
A Study on Relationship Between Resected Normal Liver Parenchymal Volume（RNLV）and Post-Hepatectomy Liver Failure (PHLF)
The post-hepatotectomy liver failure (PHLF) is still the most worrisome complication of hepatic resection. Surgeons have always been making efforts to preoperatively predict PHLF using kinds of techniques, scoring systems, and…
- Trial name
- RNLV (NCT06366048)
- Testing
- the different definitions of PHLF according to 50-50 criteria and ISGLS criteria
- Where
- 3 sites in China
- Volunteers
- 1,600 people
- Sponsor
- National Natural Science Foundation of China
Liver Failure After Operative Procedure
A Machine Learning Architecture to Predict Post-Hepatectomy Liver Failure Using Liver Regeneration Biomarkers and Time-Phased Data
Post-hepatectomy liver failure (PHLF) is the leading cause of morbidity and mortality following major hepatectomy. Existing prediction models fail to capture the dynamic liver regeneration and perioperative changes, limiting…
- Trial name
- PHLF predictio (NCT05779098)
- Where
- China
- Volunteers
- 1,071 people
- Sponsor
- Shen Feng
Liver Function After Partial Liver Resection
Xenon-anesthesia on Patients Undergoing Major Liver-resection
The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.
- Trial name
- XeLiv (NCT03504033)
- Testing
- Xenon, Desflurane
- Where
- Germany
- Sponsor
- RWTH Aachen University
Hepatic Insufficiency, Blood Coagulation Disorders
Major Liver Resection: Early Clotting Disorders and Functional Impairment.
The aim of this study is to evaluate early clotting disorders through thromboelastogram and anticoagulant proteins levels (maybe also endothelial markers) and liver function by indocyanine green clearance after major liver…
- Trial name
- NCT02813538
- Testing
- Indocyanine green clearance, Thromboelastometry
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Major Hepatectomy
Evaluation of Trans-Hepatic Flow Changes in Major Hepatectomy
Changes in trans-hepatic flow after major and extended hepatectomy (EH) can lead to small for size and flow syndrome (SFSF), which is associated with a significantly higher rate of morbidity and mortality.
- Trial name
- THEFLOW (NCT03762876)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Heidelberg
Liver Failure, Liver Dysfunction
Clinical Retrospective Study Analysis of Postoperative Complications Following Hepatectomy
Hepatectomy is a crucial surgical method for treating liver diseases such as liver cancer, hepatic hemangiomas, and biliary stones.
- Trial name
- NCT06532214
- Testing
- International Study Group for Liver Surgery (ISGLS)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University