Clinical trials: Post Operative Pancreatic Fistula
Post Operative Pancreatic Fistula, Pancreatic Resection
Efficacy of Amniotic Membrane Over Pancreatic Anastomosis After Pancreaticoduodenenctomy to Preventing Pancreatic Fistula
Post-operative pancreatic fistula (POPF) after pancreatic resection is a potentially life-threatening complication occuring in up to 27% of patients undergoing a pancreatic resection.
- Conditions
- Post Operative Pancreatic Fistula, Pancreatic Resection, Biological Dressing
- Trial name
- POPF (NCT03891225)
- Testing
- Amniotic Membrane implantation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Casa di Cura Dott. Pederzoli
Pancreatectomy
Tomoelastography in Predicting Postoperative Pancreatic Fistula
Postoperative pancreatic fistula (POPF) is a prevalent and severe complication of pancreaticoenteric anastomosis; however, its accurate preoperative prediction is challenging.
- Trial name
- POPF (NCT07014800)
- Where
- China
- Volunteers
- 157 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum
Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula
Curative management of locally resectable invasive adenocarcinomas located in the cephalic region of the pancreas (pancreas, duodenum and ampulla of Vater) requires a pancreaticoduodenectomy followed by adjuvant chemotherapy.
- Conditions
- Adenocarcinoma of the Pancreas, Adenocarcinoma of the Duodenum, Ampullary Adenocarcinoma
- Trial name
- TPIAT-01 (NCT05116072)
- Testing
- total pancreatectomy, intraportal islet autotransplantation
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Lille
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic
Postoperative Pancreatic Fistula Post-pancreatoduodenectomy
Evaluation of the Perfusion of the Pancreatic Remnant With Indocyanine Green and Its Impact on the Reduction of Pancreatic Fistula After Pancreaticoduodenectomy
Postoperative pancreatic fistula (POPF) is the most common complication following cephalic duodenopancreatectomy (DPC) and is a key determinant of severe postoperative morbidity and mortality.
- Trial name
- INDOPANC (NCT07502053)
- Testing
- No Indocyanine Green, Indocyanine Green
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Pancreatic Tumor, Benign, Pancreatic Neuroendocrine Tumor
Pancreatic Fistula After Minimally Invasive Enucleation
Patients suffering from postoperative pancreatic fistula (POPF) after minimally invasive enucleation (MIEN) show a characteristic pattern of longer duration and milder symptoms, which is different from pancreatic fistula after…
- Conditions
- Pancreatic Tumor, Benign, Pancreatic Neuroendocrine Tumor, Solid Pseudopapillary Tumor of the Pancreas
- Trial name
- NCT06557408
- Where
- China
- Volunteers
- 173 people
- Sponsor
- Fudan University
Pancreatic Cancer
Post-operative Drainage After Pancreaticoduodenectomy
The study compares regular use of surgical drains and no use of surgical drains in patients subjected to pancreaticoduodenectomy with expected low to intermediate risk for post operative pancreatic fistula.
- Trial name
- Drain 1 (NCT05270564)
- Testing
- Drain, No drain
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Linkoeping University
Pancreas Neoplasm, Pancreas Cancer
Incidence of POPF in the Resection of the Left Pancreas With RFAT
This study evaluates the impact of the Radiofrequency assisted transection on the rate of postoperative pancreatic fistula (POPF) after performing distal pancreatectomies, central pancreatectomies and pancreatic enucleation
- Conditions
- Pancreas Neoplasm, Pancreas Cancer, Pancreatic Adenocarcinoma, Benign Pancreas Tumor
- Trial name
- RFATPancreas (NCT03570502)
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Hospital del Mar
Pancreatic Fistula
Prophylactic Pancreatic Stent for the Prevention of Post Operative Pancreatic Fistula
Postoperative pancreatic fistula (POPF) remains one of the most harmful complications after pancreatic resection. Some studies have indicated that endoscopic pancreatic stenting was effective in the treatment of POPF.
- Trial name
- NCT03822676
- Testing
- Prophylactic pancreatic stent
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Fistula
Study of Pancreatic Enzymes in the Drains as Early Biomarkers of Post-operative Pancreatic Fistula and Its Clinical Repercussions
Surgery is the principal treatment for benign and malignant pancreatic tumours. This surgery can be accompanied by complications among which the main one is pancreatic fistula, which leads to the flow of pancreatic juices into…
- Trial name
- LIPA-DRAIN (NCT02784990)
- Testing
- Lipase, amylase and CRP (C-reactive protein) dosages
- Where
- 10 sites in France
- Volunteers
- 770 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pancreatic Fistula
A Multicenter Randomized Controlled Study of External Pancreatic Duct Stents in Pancreaticoduodenectomy
The prognostic value of external vs internal pancreatic duct stents after pancreaticoduodenectomy remains controversial. This study aimed to evaluate the benefits of external and internal stents using the Updated Alternative…
- Trial name
- NCT05725590
- Testing
- External pancreatic duct stent, Internal pancreatic duct stent
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Periampullary Neoplasms, Pancreatic Cancer
Total Pancreatectomy With Islet Autotransplantation (TPIAT) for High-Risk Patients With Pancreatic Tumors
This is a single-center, prospective, single-arm feasibility study evaluating whether adult patients with periampullary neoplasms who are at high risk for postoperative pancreatic fistula after pancreaticoduodenectomy can be…
- Conditions
- Periampullary Neoplasms, Pancreatic Cancer, Pancreatic Neoplasms
- Trial name
- NCT07360119
- Testing
- Total Pancreatectomy with Islet Autotransplantation (TPIAT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pancreas Head Cancer, Pancreas Adenocarcinoma
Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)
The PANENCA trial aims to reduce postoperative complications in patients undergoing pancreatoduodenectomy (also known as a Whipple procedure), a complex surgical operation performed to remove tumors located in or near the head of…
- Conditions
- Pancreas Head Cancer, Pancreas Adenocarcinoma, IPMN, Pancreatic, Cholangio Carcinoma
- Trial name
- PANENCA (NCT07262957)
- Testing
- HOP bundle
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatoduodenectomy
Neck Division Level and Postoperative Pancreatic Fistula After Pancreaticoduodenectomy
Brief Summary:* Aim of the study : To evaluate if the neck division level significantly influences the postoperative pancreatic fistula rate of pancreatico-jejunal anastomosis after pancreatoduodenectomy.
- Trial name
- PaNECK (NCT03850236)
- Where
- France
- Volunteers
- 196 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Fistula
Evaluation of a Novel Pancreaticojejunostomy Technique for Pancreaticoduodenectomy
Pancreaticoduodenectomy is a surgical procedure for removing cancer in the pancreas, the bile system or the duodenum that is associated with a high rate of complications.
- Trial name
- NCT01696903
- Testing
- Pancreaticojejunostomy technique
- Where
- 2 sites in Sweden
- Volunteers
- 123 people
- Sponsor
- Karolinska Institutet
Pancreaticoduodenectomy
Early POstoperative BIomarkers in PancreatoDuodenectomy: a Spanish Nationwide Study
AIMS: To recruit a large nationwide Spanish series in order to register PF rate and other common morbidity after PD, and to perform external validation of the aforementioned score, as well as to analyze other postoperative blood…
- Trial name
- EPOBIPD (NCT04342923)
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 525 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Pancreatic Cancer, Periampullary Cancer
Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas
This is a single-center, randomized controlled trial comparing the efficacy of pancreaticojejunostomy with modified N-butyl-2-cyanoacrylate(Glubran® 2) versus standard pancreaticojejunostomy without cyanoacrylate in preventing…
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Duodenal Cancer, Cholangiocarcinoma
- Trial name
- NBCA-MS (NCT07155525)
- Testing
- Pancreaticojejunostomy with Modified N-Butyl-2-Cyanoacrylate (Glubran® 2), Standard(duct-to-mucosa) Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Minia University
Pancreatic Fistula
Use of Hemopatch as a Sealant at the Pancreaticojejunostomy After Pancreatoduodenectomy
The objective of this study is to determine the effect of the sealant patch Hemopatch, compared to current practice without any sealant, on the decrease of the postoperative pancreatic fistula on patients undergoing…
- Trial name
- NCT03419676
- Testing
- Hemopatch
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Hospital Miguel Servet
Post Operative Pancreatic Fistula
Predictors of Severity of Postoperative Pancreatic Fistula After Pancreatoduodenectomy
Pancreaticoduodenectomy is one of the commonly performed procedure for periampullary carcinoma/distal cholangio carcinoma/head of pancreas carcinoma.
- Trial name
- NCT05291923
- Testing
- no intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Distal Pancreatectomy, Postoperative Pancreatic Fistula
Comparison of Outcomes With Stapler Versus Hand-Sewn Closure After Minimally Invasive Distal Pancreatectomy
The incidence of postoperative pancreatic fistula (POPF) after Distal pancreatectomy (DP) remains high. Of the available mitigation strategies, high-quality closure of the pancreatic stump is fundamental.
- Trial name
- NCT05789459
- Testing
- Stapler, Suture
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Zhejiang University