Clinical trials: Post Operative Cognitive Dysfunction
Cognitive Dysfunction
Dexmedetomidine and Esmolol Early Post Operative Cognitive Dysfunction
Dexmedetomidine is a highly selective α2adrenoceptor agonist recently introduced to anesthesia that produces dose dependent sedation, anxiolysis, and analgesia (involving spinal and supraspinal sites) without respiratory…
- Trial name
- NCT03892512
- Testing
- Esmolol Hydrochloride, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Beni-Suef University
Post-Operative Cognitive Decline in Older Adults
Study To Analyze Memory/Thinking Problems In Older Adults After Surgery
The purpose of the study is to examine specific neuroimaging predictors of memory and executive decline in older adults at various stages after total knee replacement surgery.
- Trial name
- POCD (NCT01786577)
- Testing
- Magnetic Resonance Imaging, Cognitive assessment testing
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Florida
Genotype, Cognitive Impairment
Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery
The purpose of this study is to determine whether a certain clock-gene (HPER3) with the 5/5 genotype carries a higher risk of post-operative cognitive dysfunction.
- Trial name
- NCT01088100
- Testing
- Genotyping
- Where
- Denmark
- Volunteers
- 279 people
- Sponsor
- Herlev Hospital
Necrosis of Femoral Head, Knee Osteoarthritis
Ketamine Prevent POCD
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent.
- Trial name
- KPPOCD (NCT02220400)
- Testing
- Ketamine
- Where
- 3 sites in China
- Volunteers
- 484 people
- Sponsor
- RenJi Hospital
Surgery--Complications
Effect of Multimodal Postoperative Rehabilitation on Functional and Cognitive Decline
Older adults, especially those with frailty, have a higher risk for complications, functional and cognitive decline after urgent surgery.
- Trial name
- NCT05290532
- Testing
- Individualized exercise training
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Hospital of Navarra
Pain and Cognitive Dysfunction Management in Hip Surgery
Prospective Comparative Study Between Ultrasound-guided Quadratus Lumborum Block Versus Fascia Iliaca Compartment Block for Postoperative Pain and Cognitive Dysfunction Management in Patient Undergoing Hip Surgery
Hip fractures are more common in older people due to osteoporosis. It is estimated that around six million patients worldwide will suffer hip fractures annually by 2050 as the population ages [1].
- Trial name
- NCT06407544
- Testing
- peripheral nerve block, PCA device as rescue medication with IV morphine 1mg if VAS more than 4
- Volunteers
- 60 people
- Sponsor
- Sohag University
POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
INVESTIGATE THE ASSOCIATION BETWEEN VIRAL NEUROTOXIC INFECTION AND POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
In the last two decades, viral infections have increased dramatically : the 2003 severe acute respiratory syndrome coronavirus outbreak, the 2009 swine flu pandemic, the 2012 Middle East respiratory syndrome coronavirus outbreak…
- Trial name
- CONNECTED (NCT05806827)
- Testing
- Virological screening
- Volunteers
- 1,685 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Postoperative Cognitive Decline, Biomarkers
Patients Experiences of Early Postoperative Cognition
The study has a mixed-methods design i.e. integration of qualitative and quantitative data within a single investigation. Participants included will be patients ≥60 years that are undergoing major elective joint replacement…
- Conditions
- Postoperative Cognitive Decline, Biomarkers, Postoperative Recovery, Joint Replacement Surgery
- Trial name
- COME (NCT05361460)
- Testing
- Cognitive decline
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Cognitive Dysfunction, Postoperative Delirium
Electroencephalographic Biomarker to Predict Acute Post-operatory Cognitive Dysfunction
Acute post-operatory cognitive dysfunction states are one of the most important complications in older patients after surgery. Two acute cognitive dysfunctions have been described: postoperative delirium (PD) and postoperative…
- Trial name
- NCT04214496
- Testing
- Sedline
- Where
- 2 sites in Chile
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Chile
Postoperative Confusion
Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients
This study is to explore the effects of dexmedetomidine on postoperative cognitive dysfunction during one-lung ventilation in elder patients.
- Trial name
- NCT02134093
- Testing
- Induction of anesthesia,midazolam ,sufentanil,etomidate and rocuronium, Dexmedetomidine, Normal saline
- Volunteers
- 120 people
- Sponsor
- Tang-Du Hospital
Cardiovascular Diseases
Impact of Preoperative Frailty and Cognitive Impairment on Postoperative Outcomes in Elderly Cardiac Surgery Patients
This is a retrospective study of patients aged 65 years and older who underwent cardiac and aortic surgery between March 5, 2021 and October 12, 2022 in the operating room of Severance Cardiovascular Hospital to determine the…
- Trial name
- NCT06330532
- Where
- South Korea
- Volunteers
- 447 people
- Sponsor
- Yonsei University
Postoperative Cognitive Disorders
Impact of Combined PSi + NIRS Monitoring in the Prevention of Postoperative Cognitive Disorders in Cardiac Surgery.
Advances in cardiac medicine and anesthesia have made it possible to expand the indications for open heart surgery to increasingly older and more complex patients.
- Trial name
- NCT07267416
- Testing
- NIRS (Near Infrared Spectroscopy), SedLine®
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Brugmann University Hospital
Postoperative Cognitive Dysfunction
Correlations of Epigenetic Changes With POCD in Surgical Patients
Postoperative cognitive dysfunction (POCD) is a subtle cognitive dysfunction, especially postoperative memory impairment lasting for weeks or months. The underlying pathophysiological mechanism of POCD remain unclear.
- Trial name
- NCT02965235
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Central South University
POCD - Postoperative Cognitive Dysfunction
Cognitive Dysfunction After Cataract Surgery
Cataract surgery is commonly performed in elderly patients who are at high risk for developing postoperative cognitive dysfunction.
- Trial name
- NCT04730596
- Testing
- Ketamine, Dexmedetomidine, Normal saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Postoperative Cognitive Dysfunction, Cognitive Impairment
Exploration of Neuroimaging and Biochemical Prognostic Indicators for POCD
Postoperative cognitive dysfunction (POCD) may lead to serious consequences. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI and biochemical indicators will be used to explore the…
- Trial name
- NCT02164669
- Where
- China
- Volunteers
- 20 people
- Sponsor
- wangqiang
Smoking and POCD
The Effect of Heavy Smoking on Early Post Operative Cognitive Dysfunction in Senile Patients .
Cognitive dysfunction is the impairment of mental process of perception, memory and information processing which allow the human to acquire knowledge and plan for the future .
- Trial name
- NCT05782946
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Beni-Suef University
Postoperative Cognitive Dysfunction, Post Operative Delirium
Comparison Between the Effect of Dexmedetomidine _midazolam and ketamine_midazolam Combination
Postoperative cognitive dysfunction (POCD) is one of the most common complications after anesthesia, with a prevalence of approximately 12% and a higher prevalence of up to 41.4% in older surgical patients during the entire…
- Trial name
- NCT07074262
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Beni-Suef University
Cognitive Dysfunction
Association Between qEEG Measure and Post-Operative Cognitive Dysfunction (POCD) and Postoperative Delirium (POD)
Cognitive complications after major surgery are a common phenomenon. The incidence of Postoperative Cognitive Dysfunction (POCD), may vary from 5% to 25% in adult patients, depending on different risk factors.
- Trial name
- NCT03977350
- Testing
- EEG monitoring
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Neuroindex Ltd.
Bladder Tumor, Postoperative Cognitive Dysfunction
The Assessment of POCD After TURBT Under Spinal Anesthesia
This study evaluates the influence of premedication on cognitive functions in patients undergoing transurethral resection of bladder tumor under spinal anesthesia.
- Trial name
- NCT03029676
- Testing
- benzodiazepines, opioid, spinal anesthesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurological Outcomes in Aortic Arch Surgery Patients
The investigators hypothesize that early intervention to optimize regional cerebral oxygenation detected by cerebral oximetry monitoring during deep hypothermic circulatory arrest (DHCA) for patients undergoing aortic surgery…
- Trial name
- NCT01149148
- Testing
- INVOS Somanetics Cerebral Oximeter
- Volunteers
- 25 people
- Sponsor
- University of Michigan