Clinical trials: Post Intensive Care Unit Syndrome, active
Sepsis, Trauma Injury
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems.
- Trial name
- NCT05357170
- Testing
- Human feces collection
- Where
- United States
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Florida
Post-Intensive Care Syndrome (PICS)
Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients
Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple comorbidities although a poor…
- Trial name
- TOPICS (NCT07170527)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- ARH van Zanten, MD PhD
Post Intensive Care Syndrome
Impact of Frailty and ICU-AW on Post-ICU Fatigue Self-reported
After a prolonged stay in Intensive Care Unit (ICU), fatigue is the most common symptom reported by patients in the Post Intensive Care Syndrome (PICS).
- Trial name
- FICUF (NCT05984069)
- Testing
- observational prospective data collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cardiac Surgery, Peri Operative Medicine
Risk Factors of Atrial Fibrillation After Cardiac Surgery
Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death.
- Conditions
- Cardiac Surgery, Peri Operative Medicine, Thoracic Surgery, Cardiopulmonary Bypass
- Trial name
- PFAS (NCT07625033)
- Where
- France
- Volunteers
- 918 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
PICS, PICS-F
Post-Intensive Care Syndrome - Multicentre Prospective Registry Database of the DACH Region
Post-Intensive Care Syndrome (PICS) refers to long-term cognitive, physical, and psychological impairments that can arise after intensive care treatment.
- Trial name
- PICS-DACH (NCT07290712)
- Where
- 4 sites in Austria, Germany
- Volunteers
- 5,000 people
- Sponsor
- Medical University of Vienna
Post Intensive Care Syndrome (PICS), PTSD - Post Traumatic Stress Disorder
ICU-VR Prior to ICU Admission
Rationale: A substantial proportion of the Intensive Care Unit (ICU) survivors develop psychological impairments due to their ICU admission.
- Trial name
- NCT06642636
- Testing
- Intensive Care Unit-specific Virtual Reality
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Denzel Drop
Ischemic Stroke
Evaluation of the Efficacy of Permanent Course Combined Therapy With CYTOFLAVIN® Intravenous Solution and CYTOFLAVIN Tablets, at 2-3 Stages of Rehabilitation of Patients With Post Intensive Care Syndrome
Post intensive care syndrome (PIC syndrome) is an important problem in modern intensive care strategy. Understanding the mechanisms of PIC syndrome helps prevent it in patients with respiratory, neuromuscular transmission, and…
- Trial name
- NCT06735898
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Icu Delirium, Post Intensive Care Syndrome
ABCDEF Bundle Compliance and ICU Outcomes in Latin America
The goal of this observational study is to evaluate the degree of compliance with the ABCDEF bundle and its relationship with clinical outcomes in adult patients (aged 18 and older) admitted to intensive care units (ICUs) in…
- Conditions
- Icu Delirium, Post Intensive Care Syndrome, Critical Illness
- Trial name
- NCT07783035
- Testing
- ABCDEF Bundle Compliance Assessment
- Volunteers
- 580 people
- Sponsor
- Hospital H+ Queretaro
Post-Intensive Care Syndrome, Quality of Life
Post-ICU Syndrome Over Time in Patients With Respiratory Failure
Intensive Care Units (ICU) stabilize and maintain vital functions in critically ill patients, optimizing their survival. However, patients with prolonged stays may develop Post-ICU syndrome , characterized by physical, cognitive…
- Trial name
- PICUS2 (NCT06857513)
- Testing
- Questionnaire and Physical Exam, EuroQol 5-Dimension 3-Level, EuroQol Visual Analogue Scale (EQ-VAS)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Sepsis, Sepsis and Septic Shock
Written Sepsis Education for Patients
This pilot feasibility randomized controlled trial (RCT) aims to determine if it feasible to recruit, deliver, and evaluate a written discharge educational material (a brochure) to adult Intensive Care Unit (ICU) patients…
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis at Intensive Care Unit
- Trial name
- NCT07415096
- Testing
- Written Discharge Education, Usual Care
- Volunteers
- 30 people
- Sponsor
- McMaster University
Neuromuscular Disease in Post-Intensive Care Syndrome
Feasibility Study on the Use of a Walking Exoskeleton in the Intensive Care Unit
The purpose of this study is to evaluate the feasibility of using a lower-limb exoskeleton in the intensive care unit for early mobilization of participants with intensive care neuromyopathy.
- Trial name
- ExoRea (NCT07907237)
- Testing
- rehabilitation session assisted by an exoskeleton
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Post Intensive Care Syndrome
Post-Resuscitation Interdisciplinary Consultation System: a Randomized, Multicenter, Interventional Study to Assess Quality of Life After a Stay in the COPRéa Intensive Care Unit
A patient's stay in the ICU is not without consequences and can cause various physical and/or psychological sequelae such as anxiety, depression, post-traumatic stress disorder (PTSD), physical weakness and memory problems.
- Trial name
- COPRéa (NCT05625867)
- Testing
- Psychological and quality of life questionnaires, Interdisciplinary consultation at 4/5 months
- Where
- France
- Volunteers
- 404 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Post Intensive Care Syndrome (PICS), Cognitive Impairment
Eye Tracking for Early Identification of Post-ICU Cognitive Impairment
Some patients may have problems with memory, attention, thinking speed, or other cognitive functions after leaving the intensive care unit (ICU). This is called post-ICU cognitive impairment.
- Trial name
- NCT07676864
- Where
- China
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Acute Kidney Injury, Intra-Abdominal Hypertension
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery
The goal of this observational study is to learn whether increased pressure inside the abdomen over time is associated with acute kidney injury in adults receiving intensive care after emergency abdominal surgery.
- Trial name
- IAP-AKI (NCT07891026)
- Testing
- Serial Intra-Abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Ugur Duman
Post ICU Syndrome
Protocol for a Hybrid Implementation-effectiveness Feasibility Study of a Transdisciplinary ICU-to-home Recovery Model
This is a prospective, single-centre study which will recruit 50 adult ICU survivors over 12 months. Assessments will occur during hospitalisation and at Months 3 and 6 after hospital discharge, with a final phone follow-up at…
- Trial name
- THRIVE@TTSH (NCT07854080)
- Testing
- THRIVE@TTSH follow up program
- Volunteers
- 50 people
- Sponsor
- Tan Tock Seng Hospital
Cardiogenic Shock, Cardiogenic Shock Acute
Prospective Validation of the STOPSHOCK Score - Artificial Intelligence Based Predictive Scoring System to Identify the Risk of Developing Cardiogenic Shock (CS) in Patients Suffering From Acute Coronary Syndrome (ACS)
Cardiogenic shock (CS) is a severe complication of acute coronary syndrome (ACS) with mortality approaching 50% despite the use of percutaneous mechanical circulatory support devices (pMCS).
- Conditions
- Cardiogenic Shock, Cardiogenic Shock Acute, Cardiogenic Shock Post Myocardial Infarction, Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
- Trial name
- STOPSCHOCK (NCT07090382)
- Where
- Slovakia
- Volunteers
- 1,046 people
- Sponsor
- Premedix Academy
Chronic Pain, Post Intensive Care Unit Syndrome
The Post-ICU Pain Study
BACKGROUND: ICU survivors may experience serious psychological, physical and cognitive impairments following ICU admission, collectively termed Post Intensive Care Syndrome (PICS).
- Conditions
- Chronic Pain, Post Intensive Care Unit Syndrome, Quality of Life, Pain Disorder
- Trial name
- PIP (NCT07180407)
- Where
- 4 sites in Denmark
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
ICU Acquired Weakness, Post Intensive Care Unit Syndrome
Muscle Recovery After Critical Illness
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which…
- Conditions
- ICU Acquired Weakness, Post Intensive Care Unit Syndrome, Muscle Weakness, Critical Illness
- Trial name
- TRACER (NCT05537298)
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Esther Dupont-Versteegden
Post ICU Syndrome
MONITOR-IC Post ICU Care Study
OBJECTIVE To evaluate the clinical effectiveness and cost effectiveness of structured, multidisciplinary and personalized post-ICU care versus usual care on physical and psychological functioning, and quality of life (QoL) of ICU…
- Trial name
- MiCare (NCT05066984)
- Testing
- structured, multidisciplinary and personalized post-ICU care
- Where
- 2 sites in Netherlands
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center