Clinical trials: Positive End-Expiratory Pressure
Prostate Cancer, Urinary Bladder Cancer
Lung US for PEEP Optimization in Robotic Radical Prostatectomy or Cystectomy Patients
There is an increasing trend in the use of robotic-assisted radical prostatectomy or cystectomy (RARPC). Preventing lung atelectasis without inducing overdistention of the lung is challenging.
- Conditions
- Prostate Cancer, Urinary Bladder Cancer, Surgery, Positive End Expiratory Pressure
- Trial name
- NCT06307704
- Testing
- Lung Ultrasound - guided Stepwise PEEP, Standard Ventilation Protocol
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Nazmy Edward Seif
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children
The goal of this randomized interventional clinical trial is to learn if a standardized lung volume optimization maneuver (LVOM) is beneficial in 1.
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Cardiac Surgery, Mechanical Ventilation
- Trial name
- ILOCO (NCT07193719)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Mechanical Ventilation, Peep Titration in Lung Protective Ventilation
- Trial name
- ILOCO-CHD (NCT07486167)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Indirect Calorimetry, Mechanical Ventilation
Effect of PEEP on Indirect Calorimetry in Critically Ill Patients
Indirect calorimetry is used in intensive care to measure how much oxygen a patient consumes and how much carbon dioxide is produced.
- Conditions
- Indirect Calorimetry, Mechanical Ventilation, Positive End-Expiratory Pressure
- Trial name
- IC-PEEP (NCT07796698)
- Testing
- Protocolized PEEP Adjustment
- Volunteers
- 20 people
- Sponsor
- Vastra Gotaland Region
Positive End-expiratory Pressure (PEEP), Intracranial Pressure
The Effects of Positive End-expiratory Pressure (PEEP) on Optic Nerve Sheath Diameter in Laparoscopic Cholecystectomy
This prospective interventional study will evaluate the effects of applying positive end-expiratory pressure (PEEP) at 10 cmH₂O on optic nerve sheath diameter (ONSD) in patients undergoing elective laparoscopic cholecystectomy…
- Conditions
- Positive End-expiratory Pressure (PEEP), Intracranial Pressure, Optic Nerve Sheath Diameter, Mechanical Ventilation
- Trial name
- PEEPON (NCT06979999)
- Testing
- Positive End-Expiratory Pressure (PEEP)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Nigde Omer Halisdemir University
Postoperative Complications, Respiratory Insufficiency
Optimal PEEP for Postoperative Oxygenation and Lung Aeration (ULTRASVENT-2)
The purpose of this multicenter, randomized controlled trial (ULTRASVENT-2) is to evaluate the effect of different positive end-expiratory pressure (PEEP) levels on postoperative oxygenation and lung aeration in adult patients…
- Conditions
- Postoperative Complications, Respiratory Insufficiency, Pulmonary Atelectasis, Positive-End Expiratory Pressure
- Trial name
- ULTRASVENT-2 (NCT07613177)
- Testing
- Intraoperative Positive End-Expiratory Pressure (PEEP) Regulation
- Where
- Russia
- Volunteers
- 360 people
- Sponsor
- Moscow Multidisciplinary Clinical Center "Kommunarka"
Positive End-expiratory Pressure (PEEP)
Electrical Impedance Tomography for Identification of Optimal Positive End-expiratory Pressure in Newborn Infants
Electrical impedance tomography (EIT) enables assessment of regional lung ventilation at the bedside. EIT has been safely used in newborn infants to image intrathoracic lung volume patterns as early as from the first minute of…
- Trial name
- NCT05612256
- Testing
- Electrical impedance tomography (EIT), Forced oscillation technique (FOT), Saturation oxygenation pressure index (SOPI)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University Children's Hospital Basel
PreTerm Neonate, Positive End Expiratory Pressure (PEEP)
PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY
Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed.
- Conditions
- PreTerm Neonate, Positive End Expiratory Pressure (PEEP), Lung Recruitment, Electrical Impedance Tomography (EIT)
- Trial name
- [PEOPLE] (NCT06705257)
- Testing
- Studying the effects of varying levels of PEEP using Electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Craniotomy Surgery, Pediatric Patient Safety
The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position
This study evaluated the effect of positive end-expiratory pressure (PEEP) on optic nerve sheath diameter (ONSD), an indicator of intracranial pressure, in pediatric patients undergoing craniotomy in the supine position.
- Conditions
- Craniotomy Surgery, Pediatric Patient Safety, Pediatric Patient, Positive End-expiratory Pressure (PEEP)
- Trial name
- NCT07370779
- Testing
- General Anesthesia, Anesthetic Agents, mechanical ventilation (MV)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition…
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Positive End-expiratory Pressure (PEEP), Ventilation During Resuscitation
- Trial name
- Lazarus-PEEP (NCT06939335)
- Testing
- Disposable PEEP Valve set at 5 cm H20., Controle
- Where
- 7 sites in Belgium, France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Ghent
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS
Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery.
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Electrical Impedance Tomography, Trauma and Postoperative Pulmonary Insufficiency
- Trial name
- EIT-PEEP-SURG (NCT07313644)
- Testing
- EIT-giuded PEEP, Control
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Nguyen Dang Thu
Positive End-expiratory Pressure (PEEP), Oxygenation Index
Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation
The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric…
- Conditions
- Positive End-expiratory Pressure (PEEP), Oxygenation Index, Pediatric Intensive Care Unit, Pediatric Acute Lung Injury
- Trial name
- NCT07233304
- Testing
- Alveolar Opening Maneuver and PEEP Titration (AOM+P)
- Where
- Argentina
- Volunteers
- 143 people
- Sponsor
- Hospital de Alta Complejidad en Red
Laparoscopy, Positive End Expiratory Pressure (PEEP)
Effects of Different Peep Applications on Tissue Oxygenation, Respiratory Mechanics and Postoperative Pulmonary Complications in Laparoscopic Hysterectomy Operations
This study aims to compare the effects of two different PEEP levels (5 cmH₂O and 10 cmH₂O) during laparoscopic hysterectomy on perioperative tissue and cerebral oxygenation, respiratory mechanics, and postoperative pulmonary…
- Conditions
- Laparoscopy, Positive End Expiratory Pressure (PEEP), Respiratory Mechanics
- Trial name
- NCT07105293
- Testing
- PEEP 5 cmH2o applied group, PEEP 10 cmH2o applied group
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Mechanical Ventilation, Positive End-Expiratory Pressure
Influence of Inspiratory Pause on Ventilatory Efficiency in Robotic Surgery. A Prospective Paired Study.
The investigators aim to determine if the modification of the end inspiratory pause (EIP) during mechanical ventilation adds benefit when applied to patients undergoing robotic surgery and who are ventilated under an…
- Conditions
- Mechanical Ventilation, Positive End-Expiratory Pressure, Anesthesia
- Trial name
- NCT05514366
- Testing
- Modifying EIP under a tOLA before pneumoperitoneum, Modifying EIP under a tOLA with pneumoperitoneum, Atelectasis test
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Driving Pressure, Positive End-expiratory Pressure
Driving Pressure-guided Positive End-expiratory Pressure to Prevent Postoperative Atelectasis in Obese Children: a Prospective, Randomized Controlled Clinical Trial
At present, the use of lung protective ventilation strategies in children is mainly based on adult and intensive care unit data.
- Conditions
- Driving Pressure, Positive End-expiratory Pressure, Postoperative Atelectasis, Obese
- Trial name
- NCT06471491
- Testing
- Driving pressure-guided positive end-expiratory pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Provincial People's Hospital
Postoperative Pulmonary Complications, Positive End-expiratory Pressure
Individualized PEEP Titration on Postoperative Pulmonary Complications
This study aims to investigate the effectiveness and safety of implementing a personalized positive end-expiratory pressure (PEEP) management strategy guided by esophageal pressure (Pes), as well as its potential to reduce the…
- Conditions
- Postoperative Pulmonary Complications, Positive End-expiratory Pressure, Elderly, Laparoscopic Surgery
- Trial name
- NCT06150079
- Testing
- Pes-Guided PEEP titration
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- Shanghai Zhongshan Hospital
Laparoscopic Surgery, Pneumoperitoneum
Role of Individualized PEEP Vs Fixed PEEP in Mechanical Ventilation During Laparoscopic Surgeries
To compare the effects of Individualized positive end-expiratory pressure with recruitment maneuver on respiratory parameters and oxygenation in mechanical ventilation during laparoscopic surgeries with the fixed positive…
- Conditions
- Laparoscopic Surgery, Pneumoperitoneum, Positive End Expiratory Pressure (PEEP)
- Trial name
- NCT06929078
- Testing
- Protective lung ventilation methods with different positive end-expiratory pressure during Laparoscopic Surgeries
- Where
- Pakistan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Noor-Ul-Ain
Laparoscopic Surgery, Positive End-Expiratory Pressure
Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients
Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays.
- Conditions
- Laparoscopic Surgery, Positive End-Expiratory Pressure, Electrical Impedance Tomography
- Trial name
- PEEP-EIT (NCT06850844)
- Testing
- electrical impedance tomography, Conventional Ventilation
- Where
- Vietnam
- Volunteers
- 70 people
- Sponsor
- Nguyen Dang Thu
Robotic Thoracic Surgery, Mechanical Ventilation
Optimal Positive End-Expiratory Pressure in Robotic-Assisted Thoracic Surgery Without Capnothorax
The aim of this study is to assess the impact on lung mechanics during robotic lung resection when no capnothorax is used.
- Conditions
- Robotic Thoracic Surgery, Mechanical Ventilation, Positive End Expiratory Pressure (PEEP)
- Trial name
- NCT06784037
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Clinic of Barcelona
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of…
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Mechanical Ventilation, Electrical Impedance Tomography (EIT)
- Trial name
- PEEP (NCT06733168)
- Testing
- electrical impedance tomography, Non-EIT
- Where
- Vietnam
- Volunteers
- 76 people
- Sponsor
- Vietnam Military Medical University