Clinical trials: Polytrauma
Multiple Trauma, Polytrauma
Development and Internal Validation of a Multimodal Prediction Score for Early Hemodynamic Deterioration in Adult Polytrauma Patients
Severe traumatic injury involving multiple body regions (polytrauma) carries a high risk of rapid bleeding, tissue hypoperfusion, and circulatory collapse.
- Conditions
- Multiple Trauma, Polytrauma, Hemodynamic Instability, Traumatic Shock
- Trial name
- NCT07850427
- Volunteers
- 300 people
- Sponsor
- Assiut University
Polytrauma, Traumatic Brain Injury
Age, Traumatic Brain Injury and Injury Severity as Independent Risk Factors for In-Hospital Mortality in Polytrauma Patients.
In this study patients who were admitted to our hospital with critical injuries were enrolled retrospectively from January 2012 to December 2015.
- Trial name
- NCT04335838
- Testing
- retrospective analysis
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Trauma, Multiple
Early Norepinephrine in Trauma Patients With Hemorrhagic Shock
The goal of this clinical trial is to learn if norepinephrine works to treat trauma patients with hemorrhagic shock. It will also learn about the safety of norepinephrine.
- Trial name
- ENTHeS (NCT06977659)
- Testing
- Norepinephrine
- Where
- 2 sites in Thailand
- Volunteers
- 40 people
- Sponsor
- Visarat Palitnonkiat
Trauma, Traumatic Injury
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in…
- Conditions
- Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
- Trial name
- EPO-TRAUMA (NCT04588311)
- Testing
- Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9%
- Where
- 41 sites in Australia, Belgium and 7 more
- Volunteers
- 2,500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Emergencies, Trauma Injury
Pre-Hospital Zone 1 Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Injured Patients With Exsanguinating Sub-diaphragmatic Haemorrhage
It is unknown whether this evolved strategy (Pre-Hospital Zone I P-REBOA) is feasible and with an acceptable safety profile. This study will address this question, therefore informing the design of a prospective multicentre…
- Conditions
- Emergencies, Trauma Injury, Trauma, Multiple
- Trial name
- P-PRO (NCT04145271)
- Testing
- Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
- Where
- 4 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- Barts & The London NHS Trust
Shock, Hemorrhagic
Pre-Hospital Use of Plasma for Traumatic Hemorrhage
Type A Thawed Plasma (TP) will be compared in polytrauma patients who receive only Normal Saline (NS) (standard of care) before arrival at the hospital.
- Trial name
- PUPTH (NCT02303964)
- Testing
- Plasma, Normal saline
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Wounds and Injuries
Polytrauma and Resuscitation Impact on Innate Immunity
Major trauma can lead to a dysregulated response to secondary infection. Severe injuries are accompanied by pro- and antiinflammatory changes that affect both adaptive and innate immunity.
- Trial name
- PRIME (NCT06314841)
- Where
- 3 sites in Austria
- Volunteers
- 62 people
- Sponsor
- Ludwig Boltzmann Gesellschaft
Injuries, Multiple, Norway/Epidemiology
Trauma Registration at St. Olavs Hospital 2000-2003
St. Olavs Hospital is a trauma referral center in the region of Midtnorge. Admitting trauma patients locally and those referred from hospitals in Nord-Trøndelag, Sør-Trøndelag and Møre-Romsdal.An active trauma team was defined in…
- Conditions
- Injuries, Multiple, Norway/Epidemiology, Trauma Centers/Statistics & Numerical Data, Trauma, Multiple
- Trial name
- NCT00184470
- Volunteers
- 1,000 people
- Sponsor
- Norwegian University of Science and Technology
Multiple Trauma
Thoracic Injuries in Pediatric Polytraumatized Patients: Epidemiology, Treatment and Outcome
The present study predicts that concomitant chest injuries in polytraumatized pediatric patients are a potential source of substantial morbidity and mortality.
- Trial name
- NCT02398175
- Testing
- reanimation/intubation
- Volunteers
- 71 people
- Sponsor
- Medical University of Vienna
Kidney Injury
Acute Kidney Injury in Poly Trauma Patients
The aim of this study is to identify the incidence and the factors associated with acute kidney injury in adult poly trauma patients
- Trial name
- NCT06108765
- Volunteers
- 100 people
- Sponsor
- Assiut University
Multiple Trauma, Pain, Acute
Intranasal Ketamine Versus Intranasal Fentanyl
Abstract Background: Given the inadequate control of pain in patients with injury that refer to the emergency departments, the rapid onset of action of intranasal administration in pain management, and the avoidance of…
- Trial name
- NCT04414800
- Testing
- Ketamine, Fentanyl
- Where
- Iran
- Volunteers
- 125 people
- Sponsor
- Isfahan University of Medical Sciences
Multiple Trauma
Effects of Omega-3 Fatty Acid Supplementation on Inflammatory Response in Multisystem Trauma Patients
This study will evaluate the effects of omega-3 fatty acid supplementation on inflammation in trauma patients. The main hypothesis is that such supplementation will reduce the presence of biomarkers of systemic inflammation, as…
- Trial name
- NCT01477697
- Testing
- Omega-3
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Cincinnati
Trauma Injury, Trauma, Multiple
The Usefulness of Inflammatory Markers to Predict Poor Outcomes for Trauma Patients
1) Research Hypothesis 1. Trauma -> Inflammation -> Severe inflammation -> Poor prognosis 2. If the degree of inflammation in the serum is precisely measurable, the prognosis of patients with trauma can be predicted.
- Trial name
- NCT05441787
- Where
- South Korea
- Volunteers
- 89 people
- Sponsor
- Wonju Severance Christian Hospital
Vitamin D Deficiency, Polytrauma
Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients
Although vitamin D is known to play a major role in multiple organ functions in healthy adults, including bone homeostasis, its role in the unique population of orthopaedic polytrauma patients has not been well described.
- Conditions
- Vitamin D Deficiency, Polytrauma, Orthopedic Disorder
- Trial name
- NCT03066817
- Testing
- Ergocalciferol 8000 IU/ML Oral Liquid [DRISDOL], Propylene Glycol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York City Health and Hospitals Corporation
Trauma, Multiple, Trauma Injury
Factors Affecting Mortality and Morbidity in Trauma Patients Followed in Intensive Care Unit
In this study, the demographic and clinical characteristics of trauma patients followed up in the Intensive Care Unit of the Anesthesiology and Reanimation Clinic of the Health Sciences University Okmeydanı Training and Research…
- Trial name
- trauma (NCT05175872)
- Where
- Turkey (Türkiye)
- Volunteers
- 194 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Wounds and Injuries, Multiple Trauma
Normal Saline Versus Plasmalyte in Initial Resuscitation of Trauma Patients
The purpose of this study is to determine whether an intravenous salt solution called "Plasmalyte" causes less abnormality of the body's acid levels than a solution called "Normal Saline."
- Conditions
- Wounds and Injuries, Multiple Trauma, Disorder of Fluid Balance
- Trial name
- NCT01270854
- Testing
- Plasmalyte A, Normal Saline
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, Davis
Acute Pain, Multiple Trauma
Ketamine Patient-Controlled Analgesia for Acute Pain
This study will compare ketamine and hydromorphone as alternative patient-controlled interventions for trauma-related pain. Patients receiving ketamine PCA are expected to require less total and breakthrough opioid and to have…
- Conditions
- Acute Pain, Multiple Trauma, Fractures
- Trial name
- NCT02062879
- Testing
- Ketamine, Hydromorphone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Polytrauma, Psychological Distress
Psychological Distress in Relatives of Severely Injured Patients
Patients who have sustained and survived a polytrauma do heavily depend on the support and functioning of their family. This is only possible if the family members are physically and mentally able to cope with the situation.
- Conditions
- Polytrauma, Psychological Distress, Relatives
- Trial name
- NCT03137420
- Testing
- Numeric Scale of Family Distress
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Traumatic Brain Injury, Multiple Trauma
Evolution of Oropharyngeal and Rectal Microbiota After Severe Traumatic Brain Injury
Modifications of the human gut microbiota have been associated with different pathological conditions such as obesity, inflammatory bowel diseases and neurodegenerative diseases.
- Trial name
- BBAX (NCT03965611)
- Testing
- Oropharyngeal swab, Rectal swab, Disability rating scale (DRS-F)
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Geriatrics
Geriatric Polytrauma SOP
This study investigated whether there were improvements in the in-hospital mortality, infection rate, and rate of palliative care among geriatric trauma patients after the implementation of new standard operating procedures…
- Trial name
- NCT03319381
- Testing
- Following new SOPs
- Volunteers
- 311 people
- Sponsor
- University of Zurich