Clinical trials: Polysubstance Abuse
Polysubstance Abuse, Posttraumatic Stress Disorder
Adaption of the STAIR-NT Trauma Intervention for Polysubstance Populations
During this 36-month R34 trial, eight study phases are proposed to adapt an evidence-based post traumatic stress disorder (PTSD) intervention (STAIR-NT) and layer it into a methadone maintenance treatment (MMT) program (START…
- Trial name
- NCT06307340
- Testing
- Skills Training in Affective and Interpersonal Regulation with Narrative Therapy (STAIR-NT), Treatment as Usual
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- NYU Langone Health
Healthy
Cannabis and Polysubstance Use: Response Inhibition and Stress Exposure
The purpose of this Phase I non-therapeutic trial is to examine the neurological effects of cannabis on stress reactivity and inhibition in healthy cannabis users.
- Trial name
- CAPU RISE (NCT05261321)
- Testing
- Cannabis oil with a high ratio of THC to CBD, Cannabis oil with a high ratio of CBD to THC
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dual Diagnosis, Cocaine Abuse
Abstinence-Linked Money Management Multisite
Randomized clinical trial comparing a money management-based intervention involving storage and management of client funds, substance abuse counseling, and risk reduction counseling to individualized drug counseling.
- Conditions
- Dual Diagnosis, Cocaine Abuse, Cocaine Dependence, Polysubstance Abuse
- Trial name
- NCT01327586
- Testing
- ATM, Individual Drug Counseling
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Yale University
Opioid Use Disorder, Opioid Abuse or Dependence
CEDRN: Opioid Registry
Unregulated opioids remain a leading driver of preventable mortality and potential years of life lost in Canada. Emergency departments (EDs)-open 24/7 and frequently accessed by people who use drugs-offer critical opportunities…
- Conditions
- Opioid Use Disorder, Opioid Abuse or Dependence, Opioid Withdrawal, Polysubstance Drug Use (Indiscriminate Drug Use)
- Trial name
- CEDRN OUD (NCT07466784)
- Where
- Canada
- Volunteers
- 7,200 people
- Sponsor
- University of British Columbia
Opioid Abuse, Benzodiazepine Abuse
Opioid/Benzodiazepine Polydrug Abuse: Aim 3
In this study, the investigators will measure affective, neurocognitive and behavioral outcomes related to chronic use of opioids and benzodiazepines (screening phase), and in response to the administration of the opioid…
- Conditions
- Opioid Abuse, Benzodiazepine Abuse, Polysubstance Abuse
- Trial name
- MAP (NCT05006079)
- Testing
- Morphine, Alprazolam
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Violent Behavior, Polydrug Use
Biological and Cognitive Markers of Violent Behavior in Forensic Patients With Polysubstance Use: Retrospective Evaluation
Aggressive behavior, both in the form of violence toward others (injury-inflicting or homicide) or toward oneself (suicide or self-injures) create problems of patient management, treatment and paroles.
- Conditions
- Violent Behavior, Polydrug Use, Alcohol Abuse
- Trial name
- NCT00797329
- Testing
- chart review
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- BeerYaakov Mental Health Center
Alcohol Use Disorder, Cannabis Use
Alcohol and Cannabis Concentrates Co-Administration
The goal of this study is to learn about the effects of combining alcohol with cannabis concentrate products which contain high levels of THC.
- Trial name
- NCT05999344
- Testing
- commercially available cannabis administered prior to commercially available alcohol, commercially available alcohol administered prior to commercially available cannabis
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polysubstance Abuse, Opioid Use
Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement
The purpose of this study is to 1) examine barriers and facilitators to implementation of MI and MORE for polysubstance use and evaluate strategies for optimizing training, fidelity, and clinic uptake, and 2) evaluate patient…
- Conditions
- Polysubstance Abuse, Opioid Use, Tobacco Use
- Trial name
- NCT06033599
- Testing
- MORE and MI and NRT, MORE and No MI and NRT, Support Group and MI and NRT
- Where
- 2 sites in United States
- Volunteers
- 420 people
- Sponsor
- Rutgers, The State University of New Jersey
Polysubstance Abuse
Opioid/Benzodiazepine Polydrug Abuse
Benzodiazepine (BZD)/opioid polysubstance abuse (PSA) dramatically increases risks of overdose, disability and death; however, little is known about phenotypes that could be targeted to decrease this use and these associated…
- Trial name
- NCT03696017
- Testing
- Multi-domain assessment battery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University