Clinical trials: Polyphenol
Inflammation
Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress
The purpose of this study is to determine the effects of a single dose of cranberry beverage in healthy adults on the kinetic uptake of polyphenol compounds and polyphenol metabolites, and antioxidative and anti-inflammatory…
- Trial name
- NCT01780922
- Testing
- Low Calorie Cranberry Juice Cocktail, Cranberry Extract Beverage, Non-Cranberry Beverage
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Washington State University
COVID-19
Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19
Resveratrol is a plant polyphenol (that is sold commercially as a supplement) that might help fight coronavirus as well as help protect the body from the effects of disease (COVID-19) caused by the infection.
- Trial name
- NCT04400890
- Testing
- Resveratrol, Vitamin D3
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Marvin McCreary, MD
Stroke
Cognitive Impact of Pomegranate Polyphenols Following Ischemic Stroke
The purpose of this study is to determine whether pomegranate supplements improve cognitive functioning following stroke.
- Trial name
- NCT02442804
- Testing
- POMx
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Loma Linda University
Healthy, Thiamine and Niacin Deficiency States
Natural Versus Synthetic Vitamin B Complexes in Human
In a cross-over study the investigators evaluate the effects of natural (Panmol-B-Complex) (Pan [Greek] = all; moles [Latin] = molecules/particles - brand name) versus synthetic vitamin B complexes to identify the bioavailability…
- Conditions
- Healthy, Thiamine and Niacin Deficiency States, Pyridoxine Deficiency, Folic Acid Deficiency Anemia, Dietary
- Trial name
- NCT03444155
- Testing
- Natural Panmol-B-Complex, Synthetic Vitamin B-Complex
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Low Education, Cognition
MINDSpeed Food and Brain Training RCT
The purpose of this study is to learn how foods high in polyphenols and brain training exercises affect older adults' cognitive performance
- Conditions
- Low Education, Cognition, Cognitive Training, Polyphenols
- Trial name
- MINDSpeed (NCT03419052)
- Testing
- Speed of processing training, MIND foods, Cognitive training control
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Indiana University
Stage I Prostate Cancer, Stage IIA Prostate Cancer
Aborption and Metabolism of Lyophilized Black Raspberry Food Products in Men With Prostate Cancer Undergoing Surgery
This Phase I/Ib trial is studying the absorption and metabolism of phytochemicals found in black raspberries in men undergoing surgery for prostate cancer.
- Conditions
- Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer, Stage III Prostate Cancer
- Trial name
- NCT01823562
- Testing
- lyophilized black raspberry confection, laboratory biomarker analysis, dietary intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Mechanisms, Defense
The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex (GP-SPI) on Gut Microbiota
The overall purpose of this study is to evaluate the effect of nutritional supplementation with a well-characterized preparation of Concord grape polyphenol-soy protein isolate (GP-SPI) on the composition of the gut microbiota.
- Trial name
- NCT04018066
- Testing
- GP-SPI
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy
Comparing the Effect of Whey and Soy Protein on the Absorption of Pomegranate Polyphenols in the Human Body
This study is comparing the quantity of active metabolites from consuming pomegranate juice in three different preparations. People who participate in this study will come in to the Center for a screening visit, which includes a…
- Trial name
- NCT02233478
- Testing
- Pomegranate Juice, Soybean Flour Protein, Soy Isolate Protein
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prostate Cancer
Green Tea Extract and Prostate Cancer
The purpose of the study is to see if a green tea extract can beneficially alter several markers of cancer risk and progression.
- Trial name
- NCT00676780
- Testing
- Polyphenon E (EGCG)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Cardiovascular Disease, Oxidative Stress
Study of Chokeberry to Reduce Cardiovascular Disease Risk in Former Smokers
The purpose of this project is to determine whether chokeberry polyphenols mitigate cardiovascular disease risk in former smokers.
- Trial name
- NCT01541826
- Testing
- Chokeberry Extract, Chokeberry extract capsule, acute
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Healthy
Physiological Effects of New Polyphenol-enriched Foods in Humans
Polyphenolic compounds exert several health benefits depending on bioavailability. Encapsulation may improve bioavailability of these compounds.This study will evaluate bioavailability of some polyphenols (curcumin and cocoa…
- Trial name
- NCT01288859
- Testing
- free curcumin, encapsulated curcumin, encapsulated curcumin + PQG
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federico II University
Mild to Moderately Active Ulcerative Colitis
Pilot Study of Green Tea Extract (Polyphenon E®)in Ulcerative Colitis
Green tea consists of several components, with most research focusing on the polyphenol fraction. The polyphenol fraction(-)-epigallocatechin-3-gallate (EGCG)has been studied extensively as an anti-inflammatory agent as well as a…
- Trial name
- NCT00718094
- Testing
- Polyphenon E®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Allergic Contact Dermatitis
Red Grape Polyphenol Oral Administration to Women Affected by Nickel-mediated Allergic Contact Dermatitis
Nickel (Ni)-mediated allergic contact dermatitis (ACD) is a very common disease worldwide. Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia…
- Trial name
- Grapolyphen (NCT03902392)
- Testing
- NaturOx Group (A)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Bari
Overweight, Obese
Inflammation, Polyphenols, and Genetics
Pilot study to determine whether daily consumption of blackraspberry powder (high in polyphenols) can reduce markers of inflammation and to determine whether genetics influence baseline levels of inflammatory markers as well as…
- Trial name
- NCT01568827
- Testing
- Blackraspberry Slurry
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Diabetic Neuropathies
Effect of Cocoa Supplementation Peripheral and Autonomic Diabetic Neuropathy
Type 2 diabetes mellitus is a high incidence disease in Mexico and is associated with the development of chronic degenerative complications such as diabetic neuropathy.
- Trial name
- NCT05247034
- Testing
- Cocoa
- Where
- 3 sites in Mexico
- Volunteers
- 39 people
- Sponsor
- Anahuac University
Prevention of Hyperglycaemia
Effects of an Apple Extract on Glycaemia: The GLU-Pomme Study
Postprandial hyperglycaemia can lead to adverse modifications to functional proteins within the body and eventually lead to the development of type 2 diabetes.
- Trial name
- GLU-Pomme (NCT02940249)
- Testing
- Apple polyphenols
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy
The Blueberry Study
This is a research study about the effects of blueberries on the health of children who do not eat much fruits and vegetables. By doing this study, we hope to find out what nutrients from blueberries appear in the blood and urine…
- Trial name
- NCT04421950
- Testing
- Wild blueberry containing foods
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Diabetes Type 2
A Comparison Chocolate With and Without High Cocoa Solids in Patients With Type 2 Diabetes in a Randomised Clinical Trial
Type 2 diabetes is being acknowledged as a potential public health time bomb, whose incidence is predicted to double over the next 10 years in the UK, associated with the rise in obesity and increasing sedentary lifestyles.
- Trial name
- NCT01617603
- Testing
- Cocoa Polyphenols
- Where
- United Kingdom
- Volunteers
- 62 people
- Sponsor
- Société des Produits Nestlé (SPN)
Chronic Stable Angina
Phase II Study of STA-2 in Patients With Chronic Stable Angina
The objectives of this study are to evaluate the efficacy, pharmacological activities and safety of STA-2 in the treatment of chronic stable angina.
- Trial name
- NCT01484912
- Testing
- STA-2
- Where
- 3 sites in Taiwan
- Volunteers
- 79 people
- Sponsor
- Sinphar Pharmaceutical Co., Ltd
Inflammation, Atherosclerosis
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
Polyphenol supplements, including curcumin and resveratrol, are known to decrease inflammation, but previous polyphenol supplements were poorly absorbed and thus their effects were reduced.
- Conditions
- Inflammation, Atherosclerosis, Cardiovascular Disease
- Trial name
- PSI (NCT02998918)
- Testing
- PolyResveratrol Supplementation, Curcumin Supplementation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of South Carolina