Clinical trials: Polyphenol
Human Health, Reactive Carbonyl Species
Scavenging of Reactive Carbonyl Species by Blueberries in Humans
This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of blueberry polyphenols in humans after a single dose of dietary flavonoids.
- Conditions
- Human Health, Reactive Carbonyl Species, Polyphenols
- Trial name
- NCT07873723
- Testing
- Blueberries, control group
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Human Health, Reactive Carbonyl Species
Scavenging of Reactive Carbonyl Species by Soymilk in Humans
This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of soymilk polyphenols in humans after a single dose of dietary flavonoids.
- Conditions
- Human Health, Reactive Carbonyl Species, Polyphenols
- Trial name
- NCT07874360
- Testing
- Soymilk, Control Group
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Dysmetabolic Iron Overload Syndrome, Genetic Hemochromatosis
Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.
Dysmetabolic iron overload syndrome and genetic hemochromatosis are frequent causes of iron overload. Polyphenols are efficient iron-chelators.
- Conditions
- Dysmetabolic Iron Overload Syndrome, Genetic Hemochromatosis, Iron Absorption, Polyphenols
- Trial name
- POLYFER (NCT03453918)
- Testing
- polyphenols
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Clermont-Ferrand
Human Health, Polyphenols
Scavenging of Reactive Carbonyl Species by Apple Polyphenols in Human
This is an interventional study to investigate formation and pharmacokinetics of reactive carbonyl species adducts of apple polyphenols in human after a single dose of apple consumption.
- Conditions
- Human Health, Polyphenols, Pharmacokinetics
- Trial name
- NCT03911050
- Testing
- Apple consumption, Control group
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Healthy Adult Participants, ADME
Exploration of Potential Biomarkers of Polyphenol Intake From Artichoke By-product Supplements
The bioavailability study analyzes the absorption, distribution, metabolism, and excretion (ADME) processes of the polyphenols under study (HCAs).
- Conditions
- Healthy Adult Participants, ADME, Polyphenols Absorption Profile, Polyphenolic Compounds and Metabolism
- Trial name
- ARTI-UP ADME (NCT07615673)
- Testing
- Single intake of a supplement derived from artichoke by-products
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Iziar Amaia Ludwig Sanz Orrio
Human Health, Reactive Carbonyl Species
Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans
This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of dietary polyphenols (soymilk, green tea, and blueberry) in humans after a single dose of dietary flavonoids.
- Conditions
- Human Health, Reactive Carbonyl Species, Polyphenols
- Trial name
- NCT05773794
- Testing
- Soymilk, green tea, or blueberry, Control group
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Exercise Response, Blood Pressure Monitoring, Ambulatory
Grape Extract and Exercise Effects on Blood Pressure
Exercise and grape extract intake (i.e., polyphenol-rich product) can independently improve blood pressure and endothelial function in prehypertensive individuals. Nevertheless, their combined effects remain unexplored.
- Conditions
- Exercise Response, Blood Pressure Monitoring, Ambulatory, Polyphenol
- Trial name
- NCT06985407
- Testing
- Grape extract (VinteraTM Premium OPC)
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- University of Castilla-La Mancha
Polyphenols, Cancer Vaccine
a Polyphenol Whole Tumor Cell Vaccine in Patients With Advanced Malignant Solid Tumors
This project intends to carry out phase I clinical studies on the basis of the previous work, initially exploring the possible effective dose, evaluating its safety and tolerability, with a view to achieving long-term control of…
- Conditions
- Polyphenols, Cancer Vaccine, Advanced Solid Tumor
- Trial name
- NCT06878612
- Testing
- Polyphenol whole tumor cell vaccine
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Xingchen Peng
Polyphenols, Obesity
Effect of a Low-calorie Diet With a Prebiotic Supplement on Health of Overweight-obese Subjects.
The main objective of this project is to evaluate the effect of prebiotic supplementation on weight loss and other physiological and metabolic parameters related to excess weight in overweight/obese adult men and women, as well…
- Conditions
- Polyphenols, Obesity, Weight Loss
- Trial name
- POSTBIOTICS (NCT06710106)
- Testing
- Prebiotic + hypocaloric diet
- Where
- Spain
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Nutrition, Absorption
Bioavailability From Chickpea Meals in Ileostomists?
The matrix of a food can significantly affect how well humans can absorb and use nutrients. Plants like fruits, vegetables, nuts, grains, and legumes have cell walls that form a network around their cells.
- Conditions
- Nutrition, Absorption, Polyphenolic Compounds and Metabolism, Polyphenols Absorption Profile
- Trial name
- NCT06921811
- Testing
- Intact chickpeas, Broken chickpeas
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Low Education, Cognition
MINDSpeed Food and Brain Training RCT
The purpose of this study is to learn how foods high in polyphenols and brain training exercises affect older adults' cognitive performance
- Conditions
- Low Education, Cognition, Cognitive Training, Polyphenols
- Trial name
- MINDSpeed (NCT03419052)
- Testing
- Speed of processing training, MIND foods, Cognitive training control
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Indiana University
Polyphenols, Cardiovascular Diseases
Autonomic and Cardiovascular Recovery After the Acute Use of Resveratrol in Overweight and Obesity Individuals
The aim of this study is to understand the importance of resveratrol supplementation as a possible adjuvant in improving the metabolic profile and cardiovascular autonomic recovery of individuals with overweight and grade I…
- Conditions
- Polyphenols, Cardiovascular Diseases, Autonomic Nervous System
- Trial name
- Resveratrol (NCT06020313)
- Testing
- Resveratrol Experimental
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taisy Cinthia Ferro Cavalcante
Gut Health, Metabolism
Bioavailability of Aronia Berry Polyphenols
The objective of this study is to conduct a randomized cross-over dietary intervention among healthy adults to compare the bioavailability and the fecal polyphenol metabolites of intervention foods made with whole aronia berry…
- Conditions
- Gut Health, Metabolism, Polyphenols
- Trial name
- NCT05488886
- Testing
- Whole Aronia Berry Powder Applesauce, Aronia Berry Extract Applesauce, Phospholipid-Polyphenol Applesauce
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Microangiopathy, Diabetic, Polyphenol
Macro- and Microvascular Response to Cocoa Flavanols in Healthy and Type 2 Diabetes
The greatest challenge in our ageing society are cardiovascular diseases such as stroke, heart attack, peripheral artery disease of the legs with non-healing wounds (ulcers), or diabetes.
- Conditions
- Microangiopathy, Diabetic, Polyphenol, Optical Tomography, Vascular Endothelium
- Trial name
- NCT05449782
- Testing
- Cocoa flavanol
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Iron Metabolism Disorders, Iron Overload
Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement
Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron.
- Conditions
- Iron Metabolism Disorders, Iron Overload, Polyphenols
- Trial name
- NCT03990181
- Testing
- meal matrix & NPPS, meal matrix & CS, no-matrix & NPPS
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Healthy, Thiamine and Niacin Deficiency States
Natural Versus Synthetic Vitamin B Complexes in Human
In a cross-over study the investigators evaluate the effects of natural (Panmol-B-Complex) (Pan [Greek] = all; moles [Latin] = molecules/particles - brand name) versus synthetic vitamin B complexes to identify the bioavailability…
- Conditions
- Healthy, Thiamine and Niacin Deficiency States, Pyridoxine Deficiency, Folic Acid Deficiency Anemia, Dietary
- Trial name
- NCT03444155
- Testing
- Natural Panmol-B-Complex, Synthetic Vitamin B-Complex
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Human Health, Polyphenols
Avenanthramide and Saponin Bioavailability in Oat Bran
Avenanthramides and saponins are types of chemical compounds found naturally in oats. Avenanthramides have anti-oxidant properties, anti-atherosclerotic, anti-inflammation, and anti-proliferative effects on cancer cells in vitro.
- Conditions
- Human Health, Polyphenols, Pharmacokinetics
- Trial name
- NCT04335435
- Testing
- Oat Bran Consumption
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Polyphenols Absorption Profile
Absorption Profiles of Three Polyphenol Preparations With and Without Pollen Shell Covering
This study consists of two parts. The first part of the study looked at the absorption of three different polyphenol preparations into the blood, the variability of their absorption and whether their absorption could be enhanced…
- Trial name
- NCT02116816
- Testing
- Polyphenol
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Oxidative Stress, Muscle Fatigue
Effect of Grape Juice Consumption on the Parameters of Oxidative Stress and Muscle Fatigue in Judo Athletes
This project aims to evaluate if after 14 days of grape juice ingestion there is improvement of the parameters of strength, fatigue and oxidative stress in judo fighters.
- Conditions
- Oxidative Stress, Muscle Fatigue, Polyphenol, Free Radical Oxidation of Tissue
- Trial name
- NCT03186573
- Testing
- Grape juice, Maltodextrin
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology
Polyphenols and Risk of Dementia
This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols and the risk to develop dementia in the 12…
- Trial name
- NCT03286608
- Testing
- observational study (no intervention)
- Volunteers
- 1,329 people, healthy volunteers welcome
- Sponsor
- Jean-François Dartigues