Clinical trials: Polyphenol
Absorption and Metabolism, Effect on Vascular Function
Absorption and Metabolism of Olive Leaf Extract and Its Effect on Vascular Reactivity and Cytokine Concentrations
The purpose of this study is to determine how olive leaf is absorbed and metabolised and also whether it has any effect on the elasticity of blood vessels and the immune system.
- Conditions
- Absorption and Metabolism, Effect on Vascular Function, Effect on Cytokine Concentrations
- Trial name
- NCT01479699
- Testing
- Olive leaf extract capsules
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy Aging
A Study of Biological Effects of a Polyphenol Supplement
A randomized, double-blind, placebo controlled, cross-over trial to investigate the effect of the Investigational Product "DailyColors™" (DC) on age-related pathways in adults.
- Trial name
- MIDI (NCT05829382)
- Testing
- DailyColors™
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Emotional Eating, Overweight or Obesity
Efficacy of Satisens® in Reducing Emotional Eating
This study evaluates the efficacy of Satisens®, a dietary supplement composed of plant extracts, in reducing emotional eating and sweet cravings in healthy adults.
- Conditions
- Emotional Eating, Overweight or Obesity, Hormonal Changes, Neurotransmitter Agents
- Trial name
- Satisens (NCT07079046)
- Testing
- Intervention 1: Satisens®
- Where
- Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- José Enrique de la Rubia Ortí, Ph
Healthy
Physiological Effects of New Polyphenol-enriched Foods in Humans
Polyphenolic compounds exert several health benefits depending on bioavailability. Encapsulation may improve bioavailability of these compounds.This study will evaluate bioavailability of some polyphenols (curcumin and cocoa…
- Trial name
- NCT01288859
- Testing
- free curcumin, encapsulated curcumin, encapsulated curcumin + PQG
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federico II University
Glycemic Index
Safety and Efficacy of a Single Dose of a Polyphenol-enriched Brown Seaweed Powder in Human
The primary endpoint of this trial will be to evaluate the safety of a single administration in human of a dose of 500 mg of a polyphenol-rich algal powder when taken 30 minutes before a test meal.
- Trial name
- ICAST (NCT00936754)
- Testing
- Brown seaweed powder
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- innoVactiv Inc.
Dysbiosis
Prebiotic Effects of a Polyphenol-rich Food Product
The specific aim for this project will be to investigate a cranberry beverage as a means to restore balance in terms of the relative proportions of the various bacteria that inhabit the large intestine.
- Trial name
- NCT03659240
- Testing
- Cranberry beverage
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Healthy Adult, Cognitive Measures
Multivitamin Intervention and Cognitive Function
The purpose of this trial is to learn how a multivitamin combined blueberry polyphenol supplement (Vitals+) influences cognitive function in healthy adults.
- Trial name
- NCT06795789
- Testing
- Vitals+ (combined multivitamin and polyphenol supplement)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Braincare Limited
Blood Pressure
Effect of Hibiscus and Lippia Extract on Blood Pressure
Determine if a double-blind, randomized, placebo-controlled clinical intervention, based on a dietetic intervention and physical exercise, supplemented with a polyphenolic extract, decreases blood pressure in hypertensive…
- Trial name
- NCT03507023
- Testing
- Metabolaid®
- Where
- Spain
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Cardiovascular Diseases, Endothelial Dysfunction
Effect of Polyphenol Extract on Cardiovascular Health Markers: a 4 Way Randomised Crossover Study
Endothelial dysfunction is an early predictor of cardiovascular events in at-risk patients. It is characterized by impaired endothelium-dependent dilation and is primarily caused by reduced nitric oxide bioavailability secondary…
- Conditions
- Cardiovascular Diseases, Endothelial Dysfunction, Blood Pressure
- Trial name
- Activ Acute (NCT05220059)
- Testing
- Polyphenol extract
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Diet, Food, and Nutrition, Dietary Supplements
Bioavailability of Green Tea and Coffee Polyphenols
There is little information on the dietary intake, absorption, metabolism and bioavailability (degree to which a substance becomes available to the target tissues upon administration) of polyphenols (natural substances present in…
- Trial name
- POBAS (NCT03248115)
- Testing
- Green tea and green coffee extract tablets
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- MRC Human Nutrition Research
Osteopenia, Sarcopenia
Olive Oil Polyphenols, Vitamin D, Docosahexaenoic Acid (DHA) and Locomotor Function (PolivD3)
The present project hypothesizes that the potential protective effect of olive oil relies on its polyphenols profile (quality and quantity) and that it may be synergistic to other food components.
- Trial name
- PolivD3 (NCT01828944)
- Testing
- olive oil
- Where
- 2 sites in France
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Lesieur
Healthy Nutrition
Bioavailability and Bioactivity of Orange Polyphenols
This study will provide a greater insight into the relationship between orange consumption and health (particularly gut health) and could be used to help with the development of novel food products.
- Trial name
- ORANGUT (NCT06430138)
- Testing
- 300ml Orange Juice
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Healthy Men
Effects of Cranberry Consumption in Vascular Function in Healthy Individuals
Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content.
- Trial name
- Cranberry (NCT02517775)
- Testing
- Cranberry 320, Cranberry 640, Cranberry 960
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Toxicity, Safety Issues
Safety Assessment of P2Et Extract in Healthy Voluntary Subjects in Colombia
Caesalpinia spinosa extract is rich in gallotannins and other well characterized polyphenols and has a major antioxidant activity.
- Trial name
- NCT03663881
- Testing
- P2Et extract
- Where
- Colombia
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario San Ignacio
Dental Caries
Delivery of Polyphenols in Gum as an Anti-Caries Agent
The short-term effects of chewing gum containing xylitol and/or blackberry extract on oral microbiota was studied. Fifty healthy adults participated in a randomized, placebo-controlled, cross-over design study.
- Trial name
- BBE (NCT05133557)
- Testing
- Chewing gum containing xylitol and blackberry extract (BBE)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Craig Miller
Healthy
The Blueberry Study
This is a research study about the effects of blueberries on the health of children who do not eat much fruits and vegetables. By doing this study, we hope to find out what nutrients from blueberries appear in the blood and urine…
- Trial name
- NCT04421950
- Testing
- Wild blueberry containing foods
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Menopause
Polyphenols and Probiotics to Improve Menopausal Symptoms Via the Gut-Brain Axis
Menopause is one of the most significant lifecourse challenges for women. The decline in female sex hormones, in particular estrogen, during menopause leads to an increased risk in cardiometabolic diseases, and a decrease in…
- Trial name
- SYMPTOGUT (NCT06333223)
- Testing
- Mixture of (Poly)phenols and a probiotic supplement
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Immunity Disorders, Aging
The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
This is a prospective, interventional, single-arm, open-label pilot study of 50 patients to evaluate the effect of a polyphenol-rich nutritional supplement on epigenetic and cellular markers of immune age.
- Conditions
- Immunity Disorders, Aging, Inflammation
- Trial name
- NCT05234203
- Testing
- HTB Rejuvenate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Big Bold Health, PBC
Human Health, Reactive Carbonyl Species
Scavenging of Reactive Carbonyl Species by Soymilk in Humans
This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of soymilk polyphenols in humans after a single dose of dietary flavonoids.
- Conditions
- Human Health, Reactive Carbonyl Species, Polyphenols
- Trial name
- NCT07874360
- Testing
- Soymilk, Control Group
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Carolina Agriculture & Technical State University
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis