Clinical trials: Polyphenol
Bioavailability
Impact of the Source and Food Matrices on the Bioavailability of Peptan® (Collagen Peptides) in Healthy Subjects
The aim of this study is the comparison of the oral bioavailability of hydroxyproline, a key marker for collagen peptide intake, after ingestion of collagen peptides from different sources, sizes and together with different food…
- Trial name
- NCT04097808
- Testing
- collagen peptides
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Oral Mucositis
Polyphenol Rich Aerosol as a Support for Cancer Patients in Minimizing Side Effects After a Radiation Therapy
The aim of the study is to demonstrate in a clinical condition the effectiveness of a preparation that is a mixture of plant extracts rich in polyphenolic compounds in the aspect of supporting cancer patients in minimizing side…
- Trial name
- NCT05994638
- Testing
- Aerosol (Polyphenol-rich plant extracts, Hyaluronic Acid, Cetraria Islandica, Vitamin B3)
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- AronPharma Sp. z o. o.
Healthy Subjects
Bioavailability and Pharmacokinetic Parameters of Watermelon (Rind, Flesh and Seeds) Polyphenols
The primary objectives of the study are outlined below: 1. To investigate the relative bioavailability and absorption/kinetic profile of polyphenols after consumption of watermelon rind, flesh and seeds, respectively in an acute…
- Trial name
- WM (NCT03365960)
- Testing
- Watermelon Rind, Watermelon Flesh, Watermelon Seeds
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Mental Energy, Physical Performance
Dose Effect of a Plant Extract on Fatigue
Test the short-term effects of the acute consumption of two separate beverages containing different concentrations of polyphenols, a beverage containing 75 mg of caffeine and a flavored placebo beverage on mental energy and…
- Trial name
- NCT03870126
- Testing
- Flavored beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy
Coffee Polyphenols Antioxidants
Coffee is one of the most widely consumed beverages. It contains polyphenols (chlorogenic acids) and bioavailability of these bioactive compounds is now somewhat well understood.
- Trial name
- NCT01832662
- Testing
- coffee, maltodextrin enriched with caffeine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Hypercholesterolemia, Glycemic Response
The Cholesterol Lowering Effects of Strawberry
Primary objective is to assess strawberry intake on LDL cholesterol and its association with atherosclerosis development.
- Trial name
- STR4 (NCT02612090)
- Testing
- Active Treatment Beverage
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Elevated Blood Pressure
Effect of Grape Seed Extract on Blood Pressure
The purpose of this study is to determine whether an 8-week intervention with grape seed extract is effective in reducing daytime ambulatory blood pressure in male and postmenopausal female with elevated daytime blood pressure…
- Trial name
- NCT00869193
- Testing
- Grape seed extract
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Unilever R&D
Eye Abnormalities
Effects of a Combination of Polyphenol-rich Extracts on the Protection of Retinal Cells Against Blue Light in the Prevention of Ocular Diseases
The aim of the study is to confirm that daily supplementation with a product containing a standardized combination of polyphenol-rich extracts has a protective effect against potential blue-light-induced damage to retinal cells.
- Trial name
- NCT06004570
- Testing
- Complex product, Polyphenol-rich extracts
- Where
- Poland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- AronPharma Sp. z o. o.
Fitness
The Effect of a Combination of Orange- and Pomegranate Actives on Physical Fitness in Elderly People
The primary objective of this study is to determine the effect of daily supplementation of a combined orange- and pomegranate extract for a period of 4 weeks on physical fitness compared to placebo.
- Trial name
- NCT03781999
- Testing
- Actiful
- Where
- Netherlands
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- BioActor
Skill Performance, Soccer Performance
Influence of Coffeeberry Ingestion on Soccer Skill Performance
The study of soccer skill performance has 3 objectives. Objective 1 is to compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and precision and passing and shooting speed and accuracy compared to…
- Conditions
- Skill Performance, Soccer Performance, Coffeeberry Effects
- Trial name
- NCT04181619
- Testing
- Coffeeberry beverage, Comparator beverage
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Postprandial Period
Effect of Drinks Containing Fruit Polyphenol Extracts and Fibre on Postprandial Glycaemia. (Glu-MIX)
Postprandial glycaemia refers to the transient rise in blood glucose levels that occurs after consuming a meal. Large fluctuations in blood glucose levels, experienced on a frequent basis, may impair the functioning of pancreatic…
- Trial name
- NCT03572296
- Testing
- Polyphenol and fibre, Fibre
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lucozade Ribena Suntory
Overweight
Bioavailability, Pharmacokinetic and Mechanistic Study of Sinetrol® Xpur, a Polyphenol-rich Ingredient
The purpose of the study is to investigate the metabolization and the bioavailability of bioactive compounds from Sinetrol® Xpur, a polyphenol-rich ingredient, during a 16-week long chronical supplementation.
- Trial name
- NCT03823196
- Testing
- Verum900, Verum1800
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fytexia
Pre Diabetic
How Fig Polyphenols Affect Blood Sugar and Insulin Levels After Eating in Adults at Risk for Diabetes
The study purpose is to understand how the body absorbs and metabolizes nutrient-like components in dried figs called polyphenols over 24 hours.
- Trial name
- FG (NCT07625046)
- Testing
- Fig, Control
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
NAFLD, MASLD
Determination of Biological Activity of Enriched Serum Following TOTUM-448 Consumption
Dietary intakes of saturated fatty acids remain well above nutritional recommendations for most European countries. This may progressively lead to a pro-inflammatory context and the alteration of lipid metabolism in the liver.
- Conditions
- NAFLD, MASLD, Mild Inflammatory Context
- Trial name
- CnC-TOTUM448 (NCT06047847)
- Testing
- TOTUM-448
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Healthy Adults
Differential Absorption Kinetics of Grape Seed Extract Polyphenols
Grape seed extracts (GSEs) contain (poly)phenols that vary in their degree of polymerization, which may lead to differences in absorption, metabolism, and biological efficacy.
- Trial name
- GSE_PK (NCT07886385)
- Testing
- MN-BP Grape Seed Extract, Commercially Available Grape Seed Extract, Gen 2 GSE - Monomer-Enriched
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Insulin Resistant
Red Raspberries on Insulin Action and Oxidative Stress
The purpose of this study is to investigate the relative bioavailability and absorption/kinetic profile of red raspberry polyphenols consumed with a meal and further to determine the relationship of these findings on…
- Trial name
- RRB (NCT02479035)
- Testing
- Red raspberry meal 1, Red raspberry meal 2, Control meal
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Borderline Hypertension
Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilatory Function
Effect of apple polyphenols on FMD.
- Trial name
- NCT01690676
- Testing
- Epicatechin, Microcrystalline cellulose
- Where
- Finland
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Danisco
Exercise Performance
The Effect of a Citrus Extract on Exercise Performance in Moderately Trained Athletes
In this study, the effect of citrus extract on exercise performance will be investigated. The study consists of three groups: one group will receive a high dose citrus extract, one group will receive a low dose citrus extract and…
- Trial name
- NCT03044444
- Testing
- citrus extract
- Where
- Netherlands
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- BioActor
Polyphenolic Compounds and Metabolism
Acute Effects of Grape Seed Extract on Insulin Sensitivity and Oxidative Stress and Inflammation Markers.
The proposed study aims to investigate that consumption of grape seed extract (GSE) would improve antioxidant status and impaired insulin action following consumption of a pro-oxidative high carbohydrate, high fat (HCHF) meal in…
- Trial name
- GSE2 (NCT01995643)
- Testing
- Active Capsule
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Premenopausal Women, Overweight and Obese Women
A Pilot Study to Characterize the Bioavailability and Plasma Profile of Potato Polyphenols in Humans
Primary objective is to determine the bioavailability of and characterize the kinetic profile of target polyphenol metabolites of potatoes over 6 hour postprandial period.
- Trial name
- PPT (NCT02167607)
- Testing
- Active Comparator
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology