Clinical trials: Polypharmacy, open to volunteers
Adverse Drug Reaction (ADR), Polypharmacy Patients
IPGx PILOT Whole Genome Sequencing Extension Cohort
The investigator's primary aim is to evaluate polypharmacy-associated adverse drug reactions (ADR) in a pilot study of at-risk patients using state-of-the-art pharmacogenomic technology and to use this information to make…
- Trial name
- NCT06766071
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Texas A&M University
Poly Pharmacy, Frail Elderly
Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)
The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy…
- Trial name
- AMIDA-ICH (NCT07015112)
- Testing
- Patient-centered multidisciplinary treatment review
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Parc Sanitari Pere Virgili
Polypharmacy, Multimorbidity
Reduction of Polypharmacy in Elderly People With Multiple Diseases
Elderly GP patients are often treated with five or more medications and therefore prone to adverse drug reactions (ADR). Potentially inappropriate prescriptions (PIPs) lead to increased adverse events like falls, hospitalizations…
- Trial name
- RED (NCT05526963)
- Testing
- Medication plan review, Adherence support
- Where
- Germany
- Volunteers
- 1,146 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Dose Administration Aids, Medication Adherence
Testing a Smart Medication Dispenser (Mobili®) to Help People With Chronic Conditions Take Their Medicine
Medication adherence is one of the biggest challenges faced by healthcare systems, especially among people with multiple chronic diseases who take several medications daily.
- Conditions
- Dose Administration Aids, Medication Adherence, Polypharmacy, Technology in Health
- Trial name
- MobiMAd@PT RCT (NCT07175545)
- Testing
- Independent use of the Mobili® Device by patients, overseen by pharmacists
- Where
- Portugal
- Volunteers
- 96 people
- Sponsor
- Lusofona University
Diabetes, Cholesterol
Interprofessional Pharmacogenomics (IPGx) Registry and Repository
This program collects genetic and health information to help doctors choose the right medications for patients.
- Conditions
- Diabetes, Cholesterol, Cancer, Blood Pressure Disorders
- Trial name
- IPGx Registry (NCT06726590)
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Texas A&M University
Alzheimer s Disease, Vascular Dementia
Predictors of Emergency Department Use in Frail Patients
When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed.
- Conditions
- Alzheimer s Disease, Vascular Dementia, Frailty, Elderly
- Trial name
- THE-Spoke 10 (NCT07259499)
- Testing
- Plasma phosphorylated Tau 181
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Pisa
Sarcopenia
(De)Prescribing in Hospitalized Sarcopenic Geriatric Patients
The goal of this clinical trial is to compare the effects of a deprescribing pharmacotherapy approach to the STOPP-START approach (usual care) in geriatric patients with sarcopenia and polypharmacy.
- Trial name
- MEDEGESARC (NCT05757765)
- Testing
- deprescribing pharmacotherapy approach (DPA), STOPP-START deprescribing approach (SSA)
- Volunteers
- 160 people
- Sponsor
- Zuyderland Medisch Centrum
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hiv, Alcohol Drinking
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
The focus of this pilot will be on falls and neurocognitive symptoms, and the impact of alcohol, cannabis use, and medications on these outcomes.
- Conditions
- Hiv, Alcohol Drinking, Fall, Cannabis Use
- Trial name
- HARP (NCT06513819)
- Testing
- Information Motivation Behavioral and Motivational Interviewing (IMB-MI) technique
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Rheumatic Diseases, Inflammatory Arthritis
The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions
The goal of this prospective observational quality improvement study is to determine if a physician tool, MedSafer, combined with educational brochures for patients, can help to reduce the use of 'potentially inappropriate…
- Conditions
- Rheumatic Diseases, Inflammatory Arthritis, Systemic Lupus Erthematosus (SLE), Vasculitis
- Trial name
- NCT07278609
- Testing
- MedSafer deprescribing opportunity reports, EMPOWER brochures
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Post Intensive Care Syndrome (PICS), Polypharmacy
The Critical Care Recovery Program: Use of a Structured Clinic Visit to Reduce Adverse Drug Events in ICU Survivors
Background and Objective: Intensive Care Units (ICUs) save lives, but many ICU survivors face ongoing health issues, including adverse drug events (ADEs) from medications started during their hospital stay.
- Conditions
- Post Intensive Care Syndrome (PICS), Polypharmacy, Adverse Drug Events, Critical Care, Intensive Care
- Trial name
- CCRP (NCT06723860)
- Volunteers
- 3,000 people
- Sponsor
- University of British Columbia
Chronic Lower Back Pain (CLBP)
Mechanistic Evaluation of Polypharmacy Effects for Pain
This is a single-group, within-subject, double-blind, double-dummy, placebo-controlled study evaluating whether gabapentin (Neurontin) changes the analgesic, safety, and subjective effects of the opioid hydromorphone (Dilaudid)…
- Trial name
- PAT (NCT07846020)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Maryland, Baltimore
Risk Factors, Polypharmacy
Telecommunication Technology-based Online Survey
The aim of this study is to identify and assess new health-associated risk factors, including clinical-pharmacological risk factors. The cohort is built using telecommunication approaches.
- Conditions
- Risk Factors, Polypharmacy, Drug Interactions, Self Medication
- Trial name
- NCT06159699
- Testing
- Online Survey, Genetic Testing
- Where
- Russia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
HIV (Human Immunodeficiency Virus)
Multimorbidity and Polypharmacy in People With HIV vs. the General Population in the Basque Country
People living with HIV now have a life expectancy similar to that of the general population, thanks to major advances in antiretroviral treatment.
- Trial name
- NCT07621224
- Testing
- No intervention
- Volunteers
- 12,546 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute
Polypharmacy
A Digital Tool to Help Doctors and Pharmacists Prescribe Medicines More Safely for Older Adults in Oman
This is a prospective, multi-phase interventional study evaluating the clinical utility and efficacy of POLYMED-a bilingual (Arabic/English) web-based, explainable-AI medication risk calculator-on optimizing geriatric medication…
- Trial name
- POLYMED (NCT07840222)
- Testing
- OPIP Score Calculator (Oman Potentially Inappropriate Prescribing Risk Score)
- Volunteers
- 400 people
- Sponsor
- Oman Ministry of Health
Aging, Adverse Drug Interaction
MinMed: Do Older Adults do Better With Less Medication
Many health care providers believe "less-is-more" for older adults, and evidence suggests minimizing certain medications might improve health outcomes.
- Conditions
- Aging, Adverse Drug Interaction, Frailty
- Trial name
- NCT05307666
- Testing
- Medication minimization
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Chronic Kidney Diseases
Deprescribing Intervention for Patients With Chronic Kidney Disease
Chronic Kidney Disease (CKD) is recognized as a leading health problem globally. It is associated with multiple consequences such as cardiovascular diseases, infections, reduced cognitive function, and higher mortality rates.
- Trial name
- NCT06324045
- Testing
- Deprescribing
- Where
- Qatar
- Volunteers
- 424 people
- Sponsor
- Hamad Medical Corporation
Multimorbidity
A New Organisation of Clinic for Multimorbidity and Polypharmacy
The purpose of this study is to investigate: 1) the implementation and 2) the effects of an outpatient program for patients with complex multimorbidity.
- Trial name
- NCT06735339
- Testing
- Clinic for Multimorbidity
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Central Jutland Regional Hospital
Elderly
Development, Validation and Evaluation of a Deprescribing Tool
The goal of this clinical trial is to learn if a deprescribing tool can help in reducing prescriptions with potentially inappropriate medications (PIMs), in the Indian elderly population.
- Trial name
- NCT07114094
- Testing
- Deprescribing Tool
- Where
- 2 sites in India
- Volunteers
- 1,650 people
- Sponsor
- Indian Council of Medical Research
Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs)
Impact of Pharmacotherapy Optimization in Polymedicated Lebanese Older Adults in Primary Health Care Centers
Why are the researchers doing this study? Many older adults take five or more medicines every day. Some of these medicines may no longer help them. Some may even cause harm, such as falls, confusion or tiredness.
- Conditions
- Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs), Primary Health Care, Social Determinants of Health (SDOH)
- Trial name
- PHARMACT-PHC (NCT07866677)
- Testing
- Structured pharmacotherapy optimization, Usual Care
- Where
- Lebanon
- Volunteers
- 452 people
- Sponsor
- National Institute of Public Health, Clinical Epidemiology, and Toxicology-Lebanon (INSPECT-LB)