Clinical trials: Polyp of Colon, open to volunteers
Colon Polyp, Colon Adenoma
Cold Snare Piecemeal Resection vs Cold Snare Endoscopic Mucosal Resection
The study will compare the use of cold snare piecemeal resection (CSPR) vs cold endoscopic mucosal resection (Cold EMR). The study will include two cohorts: one cohort for conventional adenomas 10-19mm in size and one cohort for…
- Conditions
- Colon Polyp, Colon Adenoma, Serrated Polyp
- Trial name
- CARDINAL (NCT06462521)
- Testing
- Cold Snare Piecemeal Resection (CSPR), Cold Snare Endoscopic Mucosal Resection (Cold EMR)
- Where
- 9 sites in United States, Canada
- Volunteers
- 570 people
- Sponsor
- Indiana University
Colon Polyp, Adenoma
Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection
The study will compare the use of a 6-month follow-up vs a 12-month follow-up after the removal of a large non-pedunculated polyp 20-50mm in size and without high grade dysplasia.
- Conditions
- Colon Polyp, Adenoma, Serrated Polyp, Recurrence, Local Neoplasm
- Trial name
- STARLING (NCT07198945)
- Testing
- 6-month follow-up, 12-month follow-up
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 546 people
- Sponsor
- Indiana University
Colonoscopy, Adenoma Detection Rate
Comparison of Adenoma Detection Rate in 3D vs. 2D Surveillance Colonoscopy
There is substantial evidence confirming that identifying and removing colorectal adenomas during colonoscopy helps prevent the development of colorectal cancer.
- Conditions
- Colonoscopy, Adenoma Detection Rate, Three Dimensional, Colon Polyps and Adenomas
- Trial name
- NCT07076966
- Testing
- 3D device
- Where
- 3 sites in Taiwan
- Volunteers
- 660 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer, Polyp of Colon
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors.
- Trial name
- ABLATION (NCT06271941)
- Testing
- Hybrid Argon Plasma Coagulation (h-APC), Snare tip soft coagulation (STSC)
- Where
- Canada
- Volunteers
- 892 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Manual Pressure, Repositioning
Water Exchange and CO2 Insufflation With Abdominal Compression Device to Reduce Manual Assistance
The goal of this trial is to evaluate whether water exchange colonoscopy and CO2-insufflation colonoscopy with an abdominal compression device (Maxbelt me3 type, Nippon Sigmax Co., Tokyo, Japan) can achieve a significantly lower…
- Conditions
- Manual Pressure, Repositioning, Colonoscopy, Colon Polyp
- Trial name
- NCT06496958
- Testing
- CO2 insufflation with an abdominal compression device, Water exchange colonoscopy
- Where
- 2 sites in Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Sessile Colonic Polyp, Serrated Lesion
Computer-Aided Water Exchange Colonoscopy With and Without Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions
The goal of this clinical trial is to compare the detection rate of clinically significant serrated lesions (CSSL) in participants undergoing water exchange (WE) colonoscopy with artificial intelligence (AI)-based computer-aided…
- Conditions
- Sessile Colonic Polyp, Serrated Lesion, Sessile Serrated Lesion, Colon Adenomas
- Trial name
- NCT07127471
- Testing
- Water exchange with AI-assisted detection, Water exchange with AI-assisted detection and LCI
- Where
- 4 sites in Canada, Italy and 2 more
- Volunteers
- 1,090 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Colorectal Cancer, Polyp of Colon
Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps
The goal of this clinical trial is to compare adverse even rates after EMR for large (≥20mm) flat colorectal polyps (so-called laterally spreading lesions, LSLs) when performing complete or no defect closure.
- Trial name
- Closure-RCT (NCT06807073)
- Testing
- Prophylactic defect closure, No prophylactic defect closure
- Where
- Canada
- Volunteers
- 686 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colon Polyp, Colorectal Carcinoma
Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer
This clinical trial evaluates the effects of exercise therapy on signs of colorectal cancer in colon tissue and blood in people who completed pelvic radiation therapy for prostate cancer.
- Conditions
- Colon Polyp, Colorectal Carcinoma, Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8
- Trial name
- NCT07790718
- Testing
- Aerobic Exercise, Biopsy Procedure, Biospecimen Collection
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- City of Hope Medical Center
Polyp of Colon, Crohn Disease
Lesion Size Measurement During Gastrointestinal Endoscopies
The goal of this prospective observational study is to assess the accuracy and reliability of laser readings obtained through AccuMeasure, in comparison to other measurements performed by gastroenterologists.
- Trial name
- AccuMeasure (NCT07770425)
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Cancer, Polyp of Colon
Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps
The goal of this clinical trial is to clarify the role of adjuvant thermal ablation for non-thermal endoscopic mucosal resection (EMR) of large (≥20mm) flat colorectal polyps (so-called laterally spreading lesions [LSLs]).
- Trial name
- COSA-RCT (NCT07242820)
- Testing
- Adjuvant thermal ablation, No adjuvant thermal ablation
- Where
- Canada
- Volunteers
- 752 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Zenker Diverticulum, Polyp of Colon
Advanced Endo-therapeutic Procedure : Registry-based Observational Study
Advanced therapeutic endoscopy procedures are of increasing importance to provide minimal invasive treatment for GI diseases. The Centre Hospitalier de l'Université de Montréal as tertiary university center is dedicated to…
- Conditions
- Zenker Diverticulum, Polyp of Colon, Colo-rectal Cancer
- Trial name
- AE Registry (NCT04117100)
- Testing
- Polypectomy or myotomy
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Polyp of Colon, Artificial Intelligence (AI)
Video/Image Library of Endoscopy Procedures for the Development of AI-empowered Endoscopy Quality Reporting and Educational Modules
The goal of this observational study is to establish a video/image library dataset of complete endoscopy or partial colonoscopy procedures for patients with rectal cancer or inflammatory bowel disease (IBD).
- Trial name
- Videotheque (NCT06822816)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Polyp of Colon, Endoscopic Mucosal Resection
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps.
- Trial name
- NCT06937671
- Testing
- Cold EMR, Hybrid EMR
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- The Cleveland Clinic
Polyp Colorectal, Rectal Adenoma
GelPOINT® Path-Assisted Endoscopic Removal of Colon and Rectal Polyps: A Feasibility and Safety Study
This prospective, single-center, observational feasibility and safety study will evaluate the use of the GelPOINT® Path transanal access platform during endoscopic submucosal dissection (ESD) for the removal of colorectal polyps.
- Conditions
- Polyp Colorectal, Rectal Adenoma, Adenoma Colon Polyp
- Trial name
- NCT07723937
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Colon Polyps, Colonoscopy
Imaging the Colon Using a Colonoscope Compatible Imaging Probe
The goal of this study is to use a colonoscope compatible device capable of taking images of the lower gastrointestinal tract. The main question it aims to answer is: Is the colonoscope compatible optical coherence tomography…
- Trial name
- NCT07365436
- Testing
- Feasibility of using a CC-OCT probe to image the GI tract
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Colon Adenomas, Colon Adenomatous Polyp
STSC-HybridAPC Trial
Margin thermal ablation after piecemeal EMR significantly reduces recurrence of large colorectal polyps. As recurrence rates are now low, the key implementation question relates to efficiency and reproducibility of different…
- Trial name
- NCT07682805
- Testing
- Snare Tip Soft Coagulation (STSC), Hybrid APC (ERBE)
- Where
- Australia
- Volunteers
- 140 people
- Sponsor
- Western Sydney Local Health District
Gastric Polyps, Intestinal Polyps
Recurrence After Gastric and Intestinal Polyp Resection
This is a retrospective and prospective cohort study designed to evaluate the recurrence rate and identify risk factors after endoscopic resection of gastric and intestinal polyps.
- Conditions
- Gastric Polyps, Intestinal Polyps, Colon Polyps, Colorectal Polyps
- Trial name
- RAGIP (NCT07314554)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- LanZhou University
Colon Adenoma, Colon Polyp
St. Paul's Advanced Resection Center Cohort for Colorectal Neoplasia (SPARC-C)
The SPARC-C study is a prospective, multi-institutional observational study of patients referred for the management of large (≥ 20mm) non-pedunculated colorectal polyps (LNPCPs).
- Conditions
- Colon Adenoma, Colon Polyp, Colon Lesion
- Trial name
- SPARC-C (NCT05402696)
- Testing
- Endoscopic tissue resection
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 3,500 people
- Sponsor
- University of British Columbia
Adenoma Colon Polyp, Adenoma Colon
Clinical Evaluation of a New Platform for Bi-manual Endoscopic Resection in the Rectum and Sigma (EndoTEM)
The goal of this clinical trial is to determine whether the use of the EndoTEM system during the endoscopic removal of polyps in the distal colon is feasible and safe.
- Trial name
- EndoTEM (NCT07146165)
- Testing
- EndoTEM resection platform and technique
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Colorectal Cancer, Adenoma Colon
Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection
This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers.
- Conditions
- Colorectal Cancer, Adenoma Colon, Adenoma Colon Polyp, Colon Adenoma
- Trial name
- BEACON (NCT07450612)
- Testing
- BEACON
- Where
- 4 sites in Italy
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- San Raffaele University