Clinical trials: Polymorphism
Systemic Lupus Erythematosus, Rheumatoid Arthritis
BAFF-var as a Biomarker of Response to B-depletive Treatment in Systemic Lupus Erythematosus and Rheumatoid Arthritis
A variant of the TNFSF13B gene, commonly referred to as BAFF-var has been associated with an increased risk of developing immune-mediated diseases, such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA).
- Conditions
- Systemic Lupus Erythematosus, Rheumatoid Arthritis, BLyS Polymorphism
- Trial name
- PREDICT (NCT05659407)
- Testing
- Belimumab in SLE patients / Rituximab in RA patients
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Cagliari
CYP2D6 Polymorphism
Effects of Retinoids on CYP2D6 Activity During Pregnancy
Prospective drug interaction study during pregnancy.
- Trial name
- NCT03117660
- Testing
- Vitamin A
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Washington
Drug Eluting Stent, Coronary Artery Disease
CathOlic Medical Center percutAneous Coronary inTervention Registry (COACT)
COACT registry is a multicenter registry of consecutive patients undergoing coronary stent implantation at 8 centers in the Catholic University of Korea to evaluate the real world management of patients with coronary artery…
- Conditions
- Drug Eluting Stent, Coronary Artery Disease, Polymorphism, Cholesterol
- Trial name
- COACT (NCT01239914)
- Where
- 8 sites in South Korea
- Volunteers
- 11,719 people
- Sponsor
- The Catholic University of Korea
Myasthenia Gravis, Ocular, Gene Polymorphism
Association Study Between VDR Gene Polymorphisms and Risk and Features of MG in Han Chinese Population
The Vitamin D receptor gene (VDR) polymorphisms are the candidate genetic variants for susceptibility to autoimmune diseases. In the present study, the investigators aimed to assess the association between VDR polymorphisms and…
- Trial name
- NCT05380128
- Testing
- Genotype analysis for VDR rs1544410, rs2228570, rs731236, and rs7975232 polymorphisms
- Where
- China
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Pharmacokinetics, Pancreatic Cancer
Study on Umorestat Hydrogen Sulfate Capsule in Patients With Locally Advanced/Metastatic Pancreatic Cancer
Based on the tolerability, safety and pharmacokinetics phase I/II clinical trials of ulimostat hydrochloride capsules (LH011) combined with gemcitabine hydrochloride (GEM) in locally advanced/metastatic pancreatic cancer…
- Conditions
- Pharmacokinetics, Pancreatic Cancer, Gene Polymorphisms
- Trial name
- NCT05329597
- Testing
- Genotyping
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
COMT Gene Polymorphism
Pharmacogenetics of Cannabinoid Response
This study attempts to examine genetic influences on the effects of tetrahydrocannabinol (Δ9-THC), the active ingredient of marijuana, cannabis, "ganja", or "pot".
- Trial name
- NCT00678730
- Testing
- delta 9 tetrahydrocannabinol
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yale University
CYP1A2 Polymorphism
Personalized Nutrition Caffeine Intake in Healthy Adults.
Personalized nutrition is one of the most up to date trends in human nutrition and gains much interest of general public and scientists as well.
- Trial name
- NCT04122053
- Testing
- Intervention group with genotype information, Control group without genotype information
- Where
- Poland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Polymorphism- Genetic, Reward Mediating System
Imaging and Genetic Investigation of Learning and Decision Making
Background: Previous research has shown that dopamine, a brain chemical, is involved in decision making. Different genes influence how much dopamine people have in their brains and how that affects their behavior.
- Trial name
- NCT01950377
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- National Institute of Mental Health (NIMH)
Abiraterone Acetate, Gene Polymorphism
Effects of Metabolic Enzymes and Transporter Gene Polymorphisms on the Pharmacokinetics and Metabolism of Oral Abiraterone Acetate in Healthy Chinese Adults
1. To explore the relationship between the changes of plasma concentration of abiraterone acetate after taken orally on fasting or postprandial and gene polymorphism. 2.
- Conditions
- Abiraterone Acetate, Gene Polymorphism, Pharmacokinetic, Metabolic Analysis
- Trial name
- NCT04735913
- Testing
- Abiraterone acetate tablets
- Where
- China
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Acute Coronary Syndrome, Lipoproteinemia
Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA)
The aim of study is to examine the relationship between lipid subfractions, inflammation and structural-functional properties of the arterial wall in patients after myocardial infarction with high lipoprotein (a) (Lp (a)) levels…
- Conditions
- Acute Coronary Syndrome, Lipoproteinemia, Inflammation, Genetic Polymorphisms
- Trial name
- NCT04993664
- Testing
- Pelacarsen (TQJ230)
- Where
- Slovenia
- Sponsor
- University Medical Centre Ljubljana
Periodontitis, Polymorphism, Restriction Fragment Length
Vitamin D Receptor, Interleukin-1A and Interleukin-1B Gene Polymorphisms in Periodontitis
Background: The aim of the study is to find out the prevelance of VDR (rs731236), IL1B (rs1143634) and IL1A (rs1800587)gene polymorphisms in Turkish population and their association with stage III grade B / C periodontitis.
- Trial name
- NCT04806971
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marmara University
Sleep, Caffeine
Protocol PERCAF 2018
In this multicentric controlled study, we aims to evaluate effect of caffeine on mental performances during a sleep deprivation protocol. Genetic polymorphisms are considered as a covariable.
- Conditions
- Sleep, Caffeine, Polymorphism
- Trial name
- PERCAF (NCT03859882)
- Testing
- Sleep deprivation
- Where
- 2 sites in France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche Biomedicale des Armees
Severe Periodontitis, Risk Factors
Risk Factors for Severe Periodontitis in 30 to 40 Year Olds: a Retrospective Study
Periodontitis is one of the most common oral diseases, which is characterized by alveolar bone resorption and destruction. In China, as a major country in the incidence of periodontitis, there is a huge population of patients…
- Conditions
- Severe Periodontitis, Risk Factors, Gene Polymorphism
- Trial name
- NCT04960774
- Testing
- Observational study, no intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gout, Hyperuricemia
Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout
To evaluate differences in specific SNPs and intestinal microflora between patients with gout and hyperuricemia and healthy controls.
- Conditions
- Gout, Hyperuricemia, Gut Microbiota, Uric Acid
- Trial name
- NCT04953533
- Testing
- no intervention
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Study the Role of SHMT1 Polymorphism in Parkinson Disease
SHMT1 Polymorphism in Parkinson's Disease,
Parkinson Disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system . SHMT has been shown to be associated with various diseases.
- Trial name
- NCT04706065
- Testing
- SHMT1 polymorphism
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Genetic Predisposition to Disease, Postoperative Nausea
Genetic Polymorphism and Post Operative Nausea and Vomiting (PONV)
Nausea and vomiting affects 25-30% of individuals in the post-operative period and can reach more than 70-80% in high-risk patients.
- Conditions
- Genetic Predisposition to Disease, Postoperative Nausea, Polymorphism, Genetic
- Trial name
- ponv (NCT03627780)
- Testing
- DNA extraction
- Where
- 2 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Polymorphism-Genetic, Pain
Genetic Effects on Dopamine Response to an Opiate
Background: Small differences in genes may alter responses to drugs. One gene that has different forms is the mu opioid receptor gene. People with one form of this gene are more sensitive to alcohol.
- Conditions
- Polymorphism-Genetic, Pain, Addiction
- Trial name
- NCT01878006
- Testing
- Morphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Polymorphism (Genetics), Endometriosis
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population
Endometriosis, defined as the presence of endometrial tissue outside the uterine cavity, affects 6-10% of the general population of women in childbearing age. The pathogenesis of the disease is unknown.
- Trial name
- NCT02388854
- Testing
- SNPs analysis with Sanger sequencing
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Dyslipidemias, Single Nucleotide Polymorphism
VDR SNPs & 25OHD Correlated With Dyslipidemia
The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese.
- Trial name
- NCT04707612
- Testing
- No intervention.
- Where
- China
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Antiplatelet Therapy, CYP2C19 Polymorphism
The Influence of Gene Polymorphism on Clinical Outcomes in Patients Undergoing PCI
Dual antiplatelet therapy with aspirin and thienopyridines is an essential treatment in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT03758248
- Testing
- CYP2C19
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Beijing Anzhen Hospital