Clinical trials: Polymorphism
Major Depression
Predictors of the Outcome of Late Life Depression
Predictors of response to pharmacological treatment of major depressive disorder will be investigated. One hundred and twenty patients will be included in a naturalistic clinical trial.
- Trial name
- NCT02441387
- Testing
- Antidepressant, Psychoeducation, Treatment as usual (only pharmacological treatment).
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Nutritional Physiological Phenomena
Gene Polymorphism of Taste Receptors and Circulating Endocannabinoids in Normal Weight and Obese Subjects
The study aims at evaluating in normal weight and obese subjects those factors such as taste sensitivity and circulating endocannabinoids in influencing dietary choice and thereby lipid and energy metabolism in order to design…
- Trial name
- NCT02729584
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Opioid Dependence, Methadone Toxicity
KCNH2 Polymorphisms on the QTc Interval in Kelantanese Malays Patients Receiving Methadone Maintenance Therapy (MMT)
Methadone maintenance therapy (MMT) is one of the modalities to prevent HIV transmission among injected drug users, particularly in opioid-dependent users.
- Conditions
- Opioid Dependence, Methadone Toxicity, HERG Gene Mutation
- Trial name
- NCT03603158
- Where
- Malaysia
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Orthopaedic Surgery
Pharmacokinetic, Pharmacodynamic and Pharmacogenetic of Morphine After Surgery
The main objective of this study is to improve our knowledge on the pharmacodynamic, pharmacokinetic, and pharmacogenetic relationships of morphine administered to relief severe postoperative pain.
- Trial name
- NCT00822549
- Testing
- intravenous morphine titration
- Where
- France
- Volunteers
- 438 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
GERD
CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing
Background/Aim: To evaluate the optimal dosage of rabeprazole for proton-pump inhibitor (PPI) testing of gastroesophageal reflux disease (GERD) and to test the influence of cytochrome P (CYP) 2C19 polymorphism in a population…
- Trial name
- NCT00354757
- Testing
- rabeprazole
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Schizophrenia
Program for the Introduction Into Clinical Practice of the Principles of Personalized and Preventive Medicine Based on the Isolation of Gene Polymorphism in Schizophrenia in People of the Kazakh Ethnic Group
This is a GWAS study that aims to identify possible candidate genes associate to schizophrenia by exploring single nucleotide polymorphism (SNP) in a group of schizophrenia, in the Kazakh population.
- Trial name
- NCT05090644
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
H. Pylori Infection
TLR 9 (rs352140) Gene Polymorphism in Helicobacter Pylori Infection
study aimed to identify the role of TLR9 (rs352140) gene in suppressing or promoting the inflammation related to H. pylori infection in children.This cross-sectional study was conducted on 50 children with positive H.
- Trial name
- NCT07289451
- Testing
- TLR TLR 9 (rs352140) gene polymorphism
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
SLE, Rheumatoid Arthritis
Efferocytosis and Genomic Polymorphism in Autoimmune Diseases
Over the past few years, growing evidences revealed that clearance of apoptotic cells by phagocytosis can result in powerful anti-inflammatory and immunosuppressive effects.
- Conditions
- SLE, Rheumatoid Arthritis, Healthy Subjects
- Trial name
- NCT00364728
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Patients With High Cholesterol Levels Needing a Lipid-lowering Therapy
Functional and Clinical Impact of CYP3A Genetic Polymorphisms on Statin Therapy
Patients needing lipid lowering therapy will be recruited before initiation of the treatment. For each patient, total and LDL cholesterol levels before start of therapy will be measured.
- Trial name
- NCT01867203
- Testing
- Genotyping
- Where
- Belgium
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Nicotine Dependence
Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy
Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers.
- Trial name
- NCT01980550
- Testing
- sublingual nicotine
- Volunteers
- 250 people
- Sponsor
- National Institute on Drug Dependence, China
Rheumatoid Arthritis
Relationship of YWHAH Polymorphisms to Rheumatoid Arthritis Disease Severity
It is hypothesized that one or several of these 6 single nucleotide polymorphisms (SNPs) (rs2246704, rs2853884, rs3747158, rs4820059, rs7291050, and rs933226) in the YWHAH gene could be related to RA disease severity.
- Trial name
- NCT03190746
- Testing
- TaqMan SNP analysis
- Volunteers
- 71 people
- Sponsor
- Keesler Air Force Base Medical Center
Androgenetic Alopecia
Association of Polymorphisms in the Androgen Receptor Gene and Finasteride Response in Women With Androgenetic Alopecia
Previous studies of finasteride treatment in women with hair loss have failed to show positive results, yet, some women have responded anecdotally.
- Trial name
- NCT01052870
- Testing
- Finasteride
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HairDx, LLC
ST Elevation (STEMI) Myocardial Infarction of Other Sites
PREdisposition Genetical in Cardiac Insufficiency = Genetic Predisposition to Heart Failure
Our main goal is to create a prospective cohort of 1500 patients with a first large myocardial infarction allowing us, in a second step, to identify susceptibility genes for the progression of patients towards chronic heart…
- Trial name
- PREGICA (NCT01113268)
- Testing
- Cohort
- Where
- France
- Volunteers
- 658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Age-Related Macular Degeneration
Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals.
- Trial name
- NCT00533754
- Testing
- drawing blood
- Where
- Austria
- Sponsor
- Rudolf Foundation Clinic
Folate, CML
FLOR3 Gene Polymorphism in Predicting Outcomes of Tyrosine Kinase Inhibitor（TKI）Stopping in Chronic Myeloid Leukemia
For patients with chronic myeloid leukemia in chronic phase (CML-CP) who have achieved a stable deep molecular response (DMR) using BCR-ABL1 tyrosine kinase inhibitors (TKIs), treatment-free remission (TFR) following TKI…
- Conditions
- Folate, CML, Treatment-free Remission
- Trial name
- NTU-CML-001 (NCT05152537)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Affiliated Hospital of Nantong University
Hepatitis B, Chronic
A Study Evaluating IL28B Polymorphism in Patients With HBeAg-Negative Chronic Hepatitis B Treated With Pegasys (Peginterferon Alfa-2a) in Study ML18253
This cross-sectional multicenter study will evaluate the IL28B polymorphism in patients with HBeAg-negative chronic hepatitis B treated with Pegasys (peginterferon alfa-2a) in the predecessor ML18253 study.
- Trial name
- NCT01697501
- Testing
- Interleukin 28B testing
- Where
- 12 sites in Italy
- Volunteers
- 88 people
- Sponsor
- Hoffmann-La Roche
Pain, Postoperative
Evaluation of Pharmacogenetic Factors Affecting Fentanyl Requirements for Postoperative Pain Control
Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control.
- Trial name
- NCT00824772
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Inje University
Parkinson Disease
Trodat 1 SPECT and Dopamine Polymorphism
The study population will include 100 parkinsonian patients in early stage of disease, with total duration not exeeding 5 years.
- Trial name
- NCT01381302
- Where
- 2 sites in Israel
- Volunteers
- 90 people
- Sponsor
- Wolfson Medical Center
Reproductive Techniques, Assisted
Efficacy of Urinary Vs Recombinant FSH in Oocyte Donors Based on Receptor N680S FSH Gene Polymorphism (Genodon Trial)
Exploratory, prospective, randomized, comparative, open trial with control group treated to assess whether the effective use of urinary FSH (uFSH) or recombinant FSH (rFSH) can be influenced by genotype of receptor N680S FSH Gene…
- Trial name
- GENODON (NCT02625519)
- Testing
- Urinary follicle-stimulating hormone, Recombinant follicle-stimulating hormone
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
DiGeorge Syndrome, 22q11.2 Deletion Syndrome
Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
22q11.2 deletion syndrome is a genetic disorder that can cause heart defects, facial abnormalities, and developmental and learning disabilities. The severity of the disorder can vary widely among people.
- Trial name
- NCT00556530
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Albert Einstein College of Medicine
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